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Total 48 results found since Jan 2013.

Elevated cerebrospinal fluid total Tau levels reflects predominant cortical involvement in Alzheimers disease (P1.093)
Conclusions:Elevated CSF Tau levels in AD patients could be surrogate biomarker for AD subtypes with predominant early cortical symptoms and atrophy. There is a need for a systematic prospective unbiased follow-up to see if rapid clinical progression in AD is related to elevated T-Tau and distinct AD subtypes.Disclosure: Dr. Pillai has nothing to disclose. Dr. Khrestian has nothing to disclose. Dr. Bekris has nothing to disclose. Dr. Safar has nothing to disclose. Dr. Leverenz has received personal compensation for activities with Axovant, GE Healthcare and Navidea Biopharmaceuticals as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pillai, J., Khrestian, M., Bekris, L., Safar, J., Leverenz, J. Tags: Aging and Dementia: Biomarkers Source Type: research

Creutzfeldt-Jakob Disease Presenting as Stroke: A Case Report and Systematic Literature Review
Conclusions: CJD develops primarily within a population in whom stroke risk factors are common and represents a rare but important stroke mimic. Negative vascular imaging in elderly patients with apparent acute stroke syndromes should prompt diagnostic review including consideration of prion diseases.
Source: The Neurologist - March 1, 2017 Category: Neurology Tags: Review Article Source Type: research

Sporadic Creutzfeldt-Jakob Disease Presenting as Non-Convulsive Status Epilepticus: A Case Report (P1.333)
CONCLUSIONS: Non-convulsive status epilepticus is an extremely rare presentation of prion disease. To date, there have only been three reported cases in the literature. This case highlights the need to consider prion disease as an etiology in NCSE and NORSE.Disclosure: Dr. Alobaidy has nothing to disclose. Dr. Parker has nothing to disclose. Dr. Bershad has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Alobaidy, A., Parker, A., Bershad, E. Tags: Fungal and Other Infectious Disorders Source Type: research

A toxic byproduct of hemoglobin could provide treatments for Creutzfeldt-Jakob disease
Scientists at Case Western Reserve University School of Medicine have identified a novel mechanism that could be used to protect the brain from damage due to stroke and a variety of...
Source: Parkinson's Disease News From Medical News Today - March 8, 2016 Category: Neurology Tags: Stroke Source Type: news

Neurologists as primary palliative care providers: Communication and practice approaches
Purpose of review: To present current knowledge and recommendations regarding communication tasks and practice approaches for neurologists as they practice primary palliative care, including discussing serious news, managing symptoms, aligning treatment with patient preferences, introducing hospice/terminal care, and using the multiprofessional approach. Recent findings: Neurologists receive little formal palliative care training yet often need to discuss prognosis in serious illness, manage intractable symptoms in chronic progressive disease, and alleviate suffering for patients and their families. Because patients with ...
Source: Neurology Clinical Practice - February 15, 2016 Category: Neurology Authors: Creutzfeldt, C. J., Robinson, M. T., Holloway, R. G. Tags: All Clinical Neurology, Prognosis, All Cerebrovascular disease/Stroke, Palliative care Review Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Palliative Care: A Core Competency for Stroke Neurologists Topical Reviews
Source: Stroke - August 24, 2015 Category: Neurology Authors: Creutzfeldt, C. J., Holloway, R. G., Curtis, J. R. Tags: Other Ethics and Policy, Emergency treatment of Stroke, Other Stroke Treatment - Medical Topical Reviews Source Type: research

Rethinking of doxycycline therapy in Creutzfeldt-Jakob disease
Compassionate use of doxycycline, a tetracycline antibiotic, in patients with Creutzfeldt-Jakob disease (CJD) revealed an increased survival of 4–7 months as compared with historical controls, a result not confirmed by a randomised, double blind, placebo-controlled trial.1 Is then therapy with doxycycline for patients with CJD over? The report of Assar et al2 on a single patient with variably protease-sensitive prionopathy (VPSPr),3 a rare subtype form of sporadic CJD, who received 4-year treatment with doxycycline at a relatively early stage of disease, suggests it is not and encourages novel studies on the use...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 12, 2015 Category: Neurosurgery Authors: Pocchiari, M., Ladogana, A. Tags: Dementia, Infection (neurology), Sleep disorders (neurology), Stroke, Variant Creutzfeld-Jakob Disease, Child and adolescent psychiatry, Memory disorders (psychiatry), Sleep disorders Editorial commentaries Source Type: research

Paradoxical herniation after decompressive craniectomy provoked by lumbar puncture or ventriculoperitoneal shunting.
CONCLUSIONS Lumbar puncture and ventriculoperitoneal shunting carry substantial risk when performed in a patient after decompressive craniectomy and before cranioplasty. When the condition that prompts decompression (such as brain swelling associated with stroke or trauma) requires time to resolve, risk is associated with lumbar puncture performed ≥ 1 month after decompressive craniectomy. PMID: 26067613 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - June 12, 2015 Category: Neurosurgery Authors: Creutzfeldt CJ, Vilela MD, Longstreth WT Tags: J Neurosurg Source Type: research

Creutzfeldt-Jakob Disease Presenting as Stroke: Case Report and Literature Review (P1.022)
CONCLUSIONS CJD develops primarily within a population in whom stroke risk factors are common and represents a rare but important stroke mimic. Negative sensitive imaging in elderly patients with apparent acute vascular syndromes should prompt diagnostic review including consideration of prion diseases.Disclosure: Dr. Van Heuven has nothing to disclose. Dr. Boggild has nothing to disclose. Dr. White has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Van Heuven, A., Boggild, M., White, R. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

An Unusual Stroke-like Clinical Presentation of Creutzfeldt-Jakob Disease: Acute Vestibular Syndrome
Conclusions: To our knowledge, this is the first report of an initial presentation of Creutzfeldt-Jacob disease closely mimicking vestibular neuritis, expanding the known clinical spectrum of prion disease presentations. Despite the initial absence of neurological signs, the central lesion location was differentiated from a benign peripheral vestibulopathy at the first visit using simple bedside vestibular tests. Familiarity with these tests could help providers prevent initial misdiagnosis of important central disorders in patients presenting vertigo or dizziness.
Source: The Neurologist - April 1, 2015 Category: Neurology Tags: Case Report/Case Series Source Type: research

Creutzfeldt-Jakob Disease
(CJD) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research

Periodic Lateralized Epileptiform Discharges (PLEDs) in Patients With Neurosyphilis and HIV Infection.
Abstract Periodic lateralized epileptiform discharges (PLEDs) are an electroencephalographic pattern recorded in the setting of a variety of brain abnormalities. It is best recognized for its association with acute viral encephalitis, stroke, tumor, or latestatus epilepticus. However, there are other conditions that have been recognized as the underlying pathology for PLEDs such as alcohol withdrawal, Creutzfeldt-Jacob disease, anoxic brain injury, and hemiplegic migraine. However, there are only rare case reports of PLEDs in patients with neurosyphilis. Here, we report 2 patients presenting with encephalopathy an...
Source: Clinical EEG and Neuroscience - October 17, 2014 Category: Neuroscience Authors: Takagaki K, Morales MK, Vitantonio D, Berkowitz F, Bell WL, Kumar PN, Motamedi GK Tags: Clin EEG Neurosci Source Type: research

Seizures after craniectomy: an under-recognised complication?
Decompressive craniectomy for ischaemic stroke is being increasingly used, at least in the USA.1 This has likely been stimulated by three randomised clinical trials reporting improved survival in appropriately selected patients.2 As the number of patients so treated, and surviving, increases, a better picture of the complications and outcomes is emerging, with recognition of the relatively high risk of infection when the cranium is reconstructed after the craniectomy, as well as the occurrence of postoperative extra-axial haemorrhages and delayed hydrocephalus.3 Creutzfeldt et al4 highlight another surprisingly frequent se...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Macdonald, R. L. Tags: Epilepsy and seizures, Hydrocephalus, Neurooncology, Stroke, CNS cancer, Drugs: psychiatry, Drugs: musculoskeletal and joint diseases, Surgical oncology Editorial commentaries Source Type: research

Seizures after decompressive hemicraniectomy for ischaemic stroke
Conclusions In this case series, patients were at high risk of developing seizures after malignant MCA stroke with DHC, especially after cranioplasty. Assuming these findings are replicated, means should be sought to reduce the occurrence of this complication.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Creutzfeldt, C. J., Tirschwell, D. L., Kim, L. J., Schubert, G. B., Longstreth, W. T., Becker, K. J. Tags: Epilepsy and seizures, Stroke Cerebrovascular disease Source Type: research