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Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
AbstractNeurological manifestations of coronavirus disease 2019 (COVID-19) are less noticeable than the respiratory symptoms, but they may be associated with disability and mortality in COVID-19. Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced “brain fog”, delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes. In this review, we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with ...
Source: Neuroscience Bulletin - September 16, 2023 Category: Neuroscience Source Type: research

Preface: Special issue “”
The special issue “Brain Proteostasis in Health and Disease” features both original and review articles written by specialists in the field of protein homeostasis. Deregulation of adequate proteostasis may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore , delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue covers the roles of protein homeostasis in several me chanisms t...
Source: Journal of Neurochemistry - July 7, 2023 Category: Neuroscience Authors: Mychael V. Lourenco Tags: EDITORIAL Source Type: research

Preface: Special issue “Brain Proteostasis in Health and Disease”
The special issue “Brain Proteostasis in Health and Disease” features both original and review articles written by specialists in the field of protein homeostasis. Deregulation of adequate proteostasis may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore , delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue covers the roles of protein homeostasis in several me chanisms t...
Source: Journal of Neurochemistry - July 6, 2023 Category: Neuroscience Authors: Mychael V. Lourenco Tags: EDITORIAL Source Type: research

Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers
CONCLUSION: A systematic understanding of particular risk factors that should not be neglected when unconventional cerebral venous thrombosis occurs and for a scientific understanding of pathophysiological mechanisms, clinical diagnosis, and treatment, thus contributing to knowledge on special types of venous stroke.PMID:37365966 | DOI:10.1111/cns.14321
Source: CNS Neuroscience and Therapeutics - June 27, 2023 Category: Neuroscience Authors: Yifan Zhou Huimin Jiang Huimin Wei Xuechun Xiao Lu Liu Xunming Ji Chen Zhou Source Type: research

Advances in Management of the Stroke Etiology One-Percenters
AbstractPurpose of ReviewUncommon causes of stroke merit specific attention; when clinicians have less common etiologies of stoke in mind, the diagnosis may come more easily. This is key, as optimal management will in many cases differs significantly from “standard” care.Recent FindingsRandomized controlled trials (RCT) on the best medical therapy in the treatment of cervical artery dissection (CeAD) have demonstrated low rates of ischemia with both antiplatelet and vitamin K antagonism. RCT evidence supports the use of anticoagulation with vitamin K antagonism in “high-risk” patients with antiphospholipid antibody...
Source: Current Neurology and Neuroscience Reports - May 29, 2023 Category: Neuroscience Source Type: research

Neuroendocrine Disruptions Following Head Injury
This article reviews hypopituitarism after TBI, the importance of pituitary hormones, and related controversies, concluding with a suggested patient approach.Recent FindingsWhile earlier studies focused on increased pituitary deficiencies after moderate-severe TBI, recent studies have focused on deficiencies after mild TBI. There has been increasing focus on the role of growth hormone after injury; growth hormone is the most frequent reported deficiency at 1  year post-TBI, and an area with unresolved questions. While more research is needed to quantify the risk of deficiencies in special populations, and establish the na...
Source: Current Neurology and Neuroscience Reports - May 6, 2023 Category: Neuroscience Source Type: research

Impact of the COVID-19 pandemic on acute stroke care: An  analysis of the 24-month data from a comprehensive stroke center in Shanghai, China
CONCLUSIONS: During the 24 months of COVID-19, a prolongation of stroke onset to hospital arrival and to intravenous rt-PA administration times were noted. Meanwhile, acute stroke patients needed to stay in the ED for a longer time before hospitalization. Educational system support and process optimization should be pursued in order to acquire timely delivery of stroke care during the pandemic.PMID:36890633 | DOI:10.1111/cns.14148
Source: CNS Neuroscience and Therapeutics - March 8, 2023 Category: Neuroscience Authors: Qimin Hu Yiming Hu Yue Gu Xiaoyan Song Yijue Shen Haiyan Lu Li Zhang Peifeng Liu Guodong Wang Chunni Guo Kan Fang Qiaoshu Wang Source Type: research

SARS-CoV-2 infection increases risk of intracranial hemorrhage
We examined 21 patients suffering from stroke and intracranial hemorrhage (ICH) and 9 (43%) of them were male. We compared relative frequencies using Fisher’s exact test. As we had few observations and many variables, we used principal component analysis (PCA) to reduce data dimensionality. We trained a linear support vector machine (SVM) on the first two PCs of the laboratory data to predict COVID-19.ResultsPatients suffering from stroke had either hypertension or SARS-CoV-2 infection, but seldom both (OR = 0.05, p = 0.0075). The presence of SARS-CoV-2 infection was strongly associated with the logarithm of CRP (p = 1.4...
Source: Frontiers in Human Neuroscience - November 24, 2022 Category: Neuroscience Source Type: research

Stroke Family Caregiver Life Changes From the COVID-19 Pandemic
CONCLUSION: Stroke family caregivers experienced both negative and positive life changes specifically as a result of the COVID-19 pandemic. Responses further indicated that COVID-19 affected most caregivers in different ways and an individualized approach is needed in dealing with caregiver life changes.
Source: Journal of Neuroscience Nursing - July 7, 2022 Category: Neuroscience Tags: Articles Source Type: research

Neurological Sequelae of COVID-19
J Integr Neurosci. 2022 Apr 6;21(3):77. doi: 10.31083/j.jin2103077.ABSTRACTBACKGROUND: Though primarily a pulmonary disease, Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus can generate devastating disease states that affect multiple organ systems including the central nervous system (CNS). The various neurological disorders associated with COVID-19 range in severity from mild symptoms such as headache, or myalgias to more severe symptoms such as stroke, psychosis, and anosmia. While some of the COVID-19 associated neurological complications are mild and reversible, a significant number of patients suffe...
Source: Journal of Integrative Neuroscience - May 28, 2022 Category: Neuroscience Authors: Samuel J Ahmad Chaim M Feigen Juan P Vazquez Andrew J Kobets David J Altschul Source Type: research

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