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Neurovascular manifestations of COVID ‑19
Nervenarzt. 2021 Mar 24. doi: 10.1007/s00115-021-01104-1. Online ahead of print.ABSTRACTEven early at the beginning of the coronavirus disease 2019 (COVID‑19) pandemic, stroke was described as a manifestation or complication of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current meta-analyses reported a stroke rate of approximately 1.5%. Stroke in COVID‑19 positive patients occurs more frequently in severe courses of the infection and in older patients with cardiovascular comorbidities; however, young patients without cardiovascular risk factors are also not uncommonly affected. The me...
Source: Der Nervenarzt - March 25, 2021 Category: Neurology Authors: Roland Veltkamp Jan C Purrucker Ralph Weber Source Type: research

Stroke Care during the COVID-19 Pandemic: International Expert Panel Review
This study, prepared by a large international panel of stroke experts, assesses the rapidly growing research and personal experience with COVID-19 stroke and offers recommendations for stroke management in this challenging new setting: modifications needed for prehospital emergency rescue and hyperacute care; inpatient intensive or stroke units; posthospitalization rehabilitation; follow-up including at-risk family and community; and multispecialty departmental developments in the allied professions.Summary: The severe acute respiratory syndrome coronavirus 2 uses spike proteins binding to tissue angiotensin-converting enz...
Source: Cerebrovascular Diseases - March 23, 2021 Category: Neurology Source Type: research

How Does SARS-CoV-2 Infection Affect Survival of Emergency Cardiovascular Patients? A Cohort Study From a German Insurance Claims Database
A previous study revealed a preliminary trend towards higher in hospital mortality in patients admitted as an emergency with acute stroke during the COVID-19 pandemic in Germany. The current study aimed to further examine the possible impact of a confirmed SARS-CoV-2 infection on in hospital mortality.
Source: European Journal of Vascular and Endovascular Surgery - March 12, 2021 Category: Surgery Authors: Christian-Alexander Behrendt, Moritz Seiffert, Christian Gerloff, Helmut L ’Hoest, Laura Acar, Götz Thomalla Source Type: research

How does SARS-CoV-2 infection affect survival among patients with cardiovascular emergencies? A cohort study from a German insurance claims database
A previous study revealed a preliminary trend towards higher in-hospital mortality in patients emergently admitted with acute stroke during the COVID-19 pandemic in Germany. The current study aims to further examine the possible impact of a confirmed SARS-CoV-2 infection on in-hospital mortality.
Source: European Journal of Vascular and Endovascular Surgery - March 12, 2021 Category: Surgery Authors: Christian-Alexander Behrendt, Moritz Seiffert, Christian Gerloff, Helmut L ’Hoest, Laura Acar, Götz Thomalla Source Type: research

Pneumonia in older adults
Purpose of review The purpose of this review is to address the relevant issues surrounding older adults with community-acquired pneumonia (CAP) today. Recent findings Approximately 1 million people>65 years have CAP in the US per year, which is more than previously reported (or realized). Older adults are vulnerable to the increasing prevalence of viral CAP, as the SARS-CoV-2 pandemic emphasizes, but pneumococcus is still the most common pathogen to cause CAP. Racial disparities continue to need to be addressed in order to improve early and late outcomes of older adults with CAP. Summary The epidemiolog...
Source: Current Opinion in Infectious Diseases - March 11, 2021 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy: the STROKOVID network
AbstractWhether and how SARS-CoV-2 outbreak affected in-hospital acute stroke care system is still matter of debate. In the setting of the STROKOVID network, a collaborative project between the ten centers designed as hubs for the treatment of acute stroke during SARS-CoV-2 outbreak in Lombardy, Italy, we retrospectively compared clinical features and process measures of patients with confirmed infection (COVID-19) and non-infected patients (non-COVID-19) who underwent reperfusion therapies for acute ischemic stroke. Between March 8 and April 30, 2020, 296 consecutive patients [median age, 74 years (interquartile range (IQ...
Source: Journal of Neurology - March 8, 2021 Category: Neurology Source Type: research

Coronavirus disease-19 (COVID-19) related acute stroke causing Transient Global Amnesia
Transient global amnesia (TGA) presents as an acute anterograde amnesia that generally resolves within 24 hrs.1 Werner et al. had noted increasing TGA since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in their hospital in Germany and reported 16 patients with TGA between February 1st and May 15th 2020 compared to their 10-year average of 9.72 In our series we noted 2 patients who presented with TGA secondary to acute hippocampal stroke in COVID-19 positive patients.
Source: Journal of Stroke and Cerebrovascular Diseases - March 5, 2021 Category: Neurology Authors: Ramnath Santosh Ramanathan, Ari Wachsman Source Type: research

Bilateral large vessel occlusion causing massive ischemic stroke in a covid-19 patient
The case of a 70-year-old male presenting an ischemic stroke related to COVID-19 infection is described. He was initially admitted to the hospital with respiratory insufficiency syndrome secondary to pneumonia caused by SARS Co2. In the next days, he developed rapid neurological deterioration characterized by drowsiness which progressed to deep coma. D-dimer was elevated. Brain CT scan showed bilateral massive ischemic stroke located in the anterior circulation, CT angiogram showed occlusion in the left internal carotid artery and the right middle cerebral artery.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Luis A. Robles Tags: Case Report Source Type: research

Thrombotic Complications of COVID-19 Infection: A Review
The novel coronavirus (severe acute respiratory syndrome CoV-2 [SARS-CoV-2]), also known as COVID-19, is a single-stranded enveloped RNA virus that created a Public Health Emergency of International Concern in January 2020, with a global case burden of over 15 million in just 7 months. Infected patients develop a wide range of clinical manifestations—typically presenting with fever, cough, myalgia, and fatigue. Severely ill patients may fall victim to acute respiratory distress syndrome, acute heart injuries, neurological manifestations, or complications due to secondary infections. These critically ill patients are also...
Source: Cardiology in Review - December 13, 2020 Category: Cardiology Tags: Review Articles Source Type: research

Neurological Associations of COVID-19 —Do We Know Enough: A Tertiary Care Hospital Based Study
This study will discuss the detailed systematically evaluated clinical profile and relevant investigations and outcome of 14 laboratory confirmed SARS-CoV-2 positive patients presenting with neurological signs and symptoms. The patients were further categorized into confirmed, probable, and possible neurological associations. The probable association was found in meningoencephalitis (n = 4), stroke (n = 2), Guillain-Barré syndrome (n = 1), and anosmia (n = 1). The other six patients had coexisting neurological diseases with SARS-CoV-2. One patient with a large artery stroke succumbed to the illness due to respiratory comp...
Source: Frontiers in Neurology - November 24, 2020 Category: Neurology Source Type: research

Intracranial hemorrhage in hospitalized SARS-CoV-2 Patients: A Case Series
The SARS-CoV-2 virus causing Coronavirus Disease 2019 (COVID-19) is a global pandemic with almost 30 million confirmed worldwide cases. Prothrombotic complications arising from those affected with severe symptoms have been reported in various medical journals. Currently, clinical trials are underway to address the questions regarding anticoagulation dosing strategies to prevent thrombosis for these critically ill patients. However, given the increasing use of therapeutic anticoagulation in patients admitted with COVID-19 to curtail this prothrombotic state, our institution has witnessed six cases of devastating intracrania...
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Fady Mousa-Ibrahim, Stephanie Berg, Oluwatobi Odetola, Michael Teitcher, Sean Ruland Source Type: research

Editorial
The cover of this issue ofBrain relates to the article by Ross Paterson, Rachel Brown and co-workers that describes the range of neurological presentations in patients with definite, probable or possible COVID-19 encountered in a series of multidisciplinary team meetings organized at a single neurological centre. The commonest CNS disorders encountered were encephalopathy without obvious structural lesion or CSF abnormality, encephalitis or encephalomyelitis, and ischaemic stroke, often in the context of a hypercoagulable state. The accepted manuscript has already been downloaded almost 30  000 times even before formal p...
Source: Brain - October 25, 2020 Category: Neurology Source Type: research

Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review
Corona virus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) is recognized as a global pandemic by WHO 2020 with 5,934 936 infections, 367,166 deaths and affecting over 200 countries as of 30th May 2020. Acute Ischemic Stroke (AIS) in brain is also emerging as an important neurovascular/neurological complication of COVID-19, associated with extreme immune responses leading to dysregulated coagulation system and generalized thrombo-embolic status and increased risk of AIS especially among usually less vulnerable younger adults in this cohort. Thus, in early June 2020, we aimed t...
Source: Frontiers in Neurology - September 24, 2020 Category: Neurology Source Type: research

Neurological Complications Among Native Americans with COVID-19: Our Experience at a Tertiary Care Academic Hospital in the U.S.
To study the central nervous system (CNS) complications in patients with COVID-19 infection especially among Native American population in the current pandemic of severe acute respiratory syndrome virus (COVID-19).
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2020 Category: Neurology Authors: Rahul Shekhar, Abu Baker Sheikh, Sajid S. Suriya, Shubra Upadhyay, Atif Zafar Source Type: research

COVID-19 Fears Keep Many Hispanic Adults With Stroke, MI Home COVID-19 Fears Keep Many Hispanic Adults With Stroke, MI Home
More than half of Hispanic adults would be afraid to go to a hospital for a possible heart attack or stroke because they might get infected with SARS-CoV-2, according to a new survey.Medscape Medical News
Source: Medscape Cardiology Headlines - July 29, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

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