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Infectious Disease: SARS
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Total 69 results found since Jan 2013.

STudy of Alteplase for Respiratory failure in SARS-Cov2 COVID-19 (STARS): A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized, Controlled Trial
Chest. 2021 Sep 27:S0012-3692(21)04063-0. doi: 10.1016/j.chest.2021.09.024. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary vascular microthrombi are a proposed mechanism of COVID19 respiratory failure. We hypothesized that early administration of tissue-plasminogen activator(tPA) followed by therapeutic heparin would improve pulmonary function in these patients.RESEARCH QUESTION: Does tPA improve pulmonary function in severe COVID-19 respiratory failure, and is it safe?STUDY DESIGN AND METHODS: Adults with COVID-19-induced respiratory failure were randomized May14,2020-March 3,2021 in two phases: Phase-1(n=36): contro...
Source: Chest - September 30, 2021 Category: Respiratory Medicine Authors: Christopher D Barrett Hunter B Moore Ernest E Moore D Janice Wang Negin Hajizadeh Walter L Biffl Lawrence Lottenberg Purvesh R Patel Michael S Truitt Robert McIntyre Todd M Bull Lee Anne Ammons Arsen Ghasabyan James Chandler Ivor Douglas Eric Schmidt Pete Source Type: research

Emergency Medical Service Workers Battle a Hurricane, and COVID-19, To Bring Health Care To New Orleans
As Hurricane Ida pounded the coast of New Orleans with downpours and 150-mile-per-hour winds on the afternoon of Aug. 29, New Orleans Emergency Medical Services had to reverse course after spending 18 months running around the city at full speed battling COVID-19: staying put. For 13 hours and 41 minutes, as the storm’s worst shook their community, the workers hunkered down at their base, keeping themselves safe to be ready to protect others from whatever came next. However, the deluge of 9-1-1 calls didn’t come to a halt as EMS waited out the storm. So, after EMS workers were given the go-ahead to rush back in...
Source: TIME: Health - September 7, 2021 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized climate change COVID-19 healthscienceclimate Source Type: news

Pediatric COVID-19 Cases Are Surging, Pushing Hospitals —and Health Care Workers—to Their Breaking Points
Aug. 20 was a good day in the pediatric intensive care unit at Children’s Hospital New Orleans. Carvase Perrilloux, a two-month-old baby who’d come in about a week earlier with respiratory syncytial virus and COVID-19, was finally ready to breathe without the ventilator keeping his tiny body alive. “You did it!” nurses in PPE cooed as they removed the tube from his airway and he took his first solo gasp, bare toes kicking. Downstairs, Quintetta Edwards was preparing for her 17-year-old son, Nelson Alexis III, to be discharged after spending more than two weeks in the hospital with COVID-19—fir...
Source: TIME: Health - August 26, 2021 Category: Consumer Health News Authors: Jamie Ducharme/New Orleans, La. Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

Impact of the sars-cov-2 pandemic on the endovascular treatment of acute stroke – an italian single-center experience
: The SARS-CoV-2 pandemic greatly influenced the overall quality of healthcare. The purpose of this study was to compare the time variables for acute stroke treatment and evaluate differences in the pre-hospital and in-hospital care before and during the SARS-CoV-2 pandemic, as well as between the first and second waves.
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2021 Category: Neurology Authors: Guglielmo Pero, Hugo Mota D ória, Matteo Giavarini, Luca Quilici, Amedeo Cervo, Antonio Macera, Mariangela Piano Source Type: research

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
Lancet Respir Med. 2021 Jul 27:S2213-2600(21)00310-6. doi: 10.1016/S2213-2600(21)00310-6. Online ahead of print.ABSTRACTBACKGROUND: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.METHODS: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. We included peo...
Source: Respiratory Care - July 30, 2021 Category: Respiratory Medicine Authors: Christopher C Butler Ly-Mee Yu Jienchi Dorward Oghenekome Gbinigie Gail Hayward Benjamin R Saville Oliver Van Hecke Nicholas Berry Michelle A Detry Christina Saunders Mark Fitzgerald Victoria Harris Ratko Djukanovic Stephan Gadola John Kirkpatrick Simon d Source Type: research

COVID-19 Has Numerous Neuropsychiatric Consequences, Report Finds
Anarticle appearing today in theJournal of Neuropsychiatry and Clinical Neurosciences provides a comprehensive overview of the neurological and psychiatric impact of the COVID-19 pandemic.“Although best known for its severe effects on respiratory function, SARS-CoV-2 produces a broad range of acute and chronic neurological and neuropsychiatric problems,” wrote Theodora Manolis, M.D., of Red Cross Hospital in Athens, Greece, and colleagues. “The COVID-19 pandemic has also had an important impact on the mental health of many individuals in the general population as a result of loss of loved ones, fear of calamity or de...
Source: Psychiatr News - July 20, 2021 Category: Psychiatry Tags: COVID-19 delirium depression headache hypoxia Journal of Neuropsychiatry and Clinical Neurosciences muscle pain neurological problems psychiatric problems psychosis stroke Source Type: research

From cellular function to global impact: the vascular perspective on COVID-19
Can J Surg. 2021 May 12;64(3):E289-E297. doi: 10.1503/cjs.023820.ABSTRACTSince COVID-19 was declared a pandemic a year ago, our understanding of its effects on the vascular system has slowly evolved. At the cellular level, SARS-CoV-2 - the virus that causes COVID-19 - accesses the vascular endothelium through the angiotensin-converting enzyme 2 (ACE-2) receptor and induces proinflammatory and prothrombotic responses. At the clinical level, these pathways lead to thromboembolic events that affect the pulmonary, extracranial, mesenteric, and lower extremity vessels. At the population level, the presence of vascular risk fact...
Source: Canadian Journal of Surgery - May 12, 2021 Category: Surgery Authors: Shira A Strauss Chanhee Seo Marc Carrier Prasad Jetty Source Type: research

Anesthetic Management for Endovascular Treatment of Stroke in Patients With Coronavirus Disease 2019: A Case Series
A significant number of patients with coronavirus disease 2019 develop strokes with large vessel obstructions that may require endovascular treatment for revascularization. Our series focuses on periprocedural issues and the anesthetic management of these patients. We analyzed medical records of 5 patients with positive reverse transcription polymerase chain reaction tests for severe acute respiratory syndrome coronavirus 2 during their hospitalization who underwent endovascular treatment at our hospital between March and mid-June 2020. We found that our patients were different from the typical patients with ischemic strok...
Source: A&A Case Reports - May 1, 2021 Category: Anesthesiology Tags: Case Series Source Type: research

Neurovascular manifestations of COVID ‑19
Nervenarzt. 2021 Mar 24. doi: 10.1007/s00115-021-01104-1. Online ahead of print.ABSTRACTEven early at the beginning of the coronavirus disease 2019 (COVID‑19) pandemic, stroke was described as a manifestation or complication of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current meta-analyses reported a stroke rate of approximately 1.5%. Stroke in COVID‑19 positive patients occurs more frequently in severe courses of the infection and in older patients with cardiovascular comorbidities; however, young patients without cardiovascular risk factors are also not uncommonly affected. The me...
Source: Der Nervenarzt - March 25, 2021 Category: Neurology Authors: Roland Veltkamp Jan C Purrucker Ralph Weber Source Type: research