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Stroke in Chagas disease: from pathophysiology to clinical practice
Rev Soc Bras Med Trop. 2022 Jun 6;55:e0575. doi: 10.1590/0037-8682-0575-2021. eCollection 2022.ABSTRACTDespite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern. The disease affects approximately 6 million people, of whom 20-40% will develop cardiomyopathy over the years after the initial Trypanosoma cruzi infection. Chagas cardiomyopathy is the most serious and frequent manifestation of Chagas disease. Clinical manifestations vary widely according to the severity of myocardial dysfunction, ranging from asymptomatic ...
Source: Atherosclerosis - June 8, 2022 Category: Cardiology Authors: Tha ís Aparecida Reis Lage Julia Teixeira Tupinamb ás Lucas Bretas de P ádua Matheus de Oliveira Ferreira Amanda Cambraia Ferreira Antonio Lucio Teixeira Maria Carmo Pereira Nunes Source Type: research

Chagas’ cardiomyopathy is associated with higher incidence of stroke: a meta-analysis of observational studies
Chagas’ disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD.
Source: Journal of Cardiac Failure - September 14, 2014 Category: Cardiology Authors: Rhanderson N. Cardoso, Francisco Yuri B. Macedo, Melissa Nolan Garcia, Daniel C. Garcia, Alexandre M. Benjo, David Aguilar, Hani Jneid, Biykem Bozkurt Tags: Clinical Investigations Source Type: research

Chagas Cardiomyopathy is Associated With Higher Incidence of Stroke: A Meta-analysis of Observational Studies
Chagas disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD.
Source: Journal of Cardiac Failure - September 14, 2014 Category: Cardiology Authors: Rhanderson N. Cardoso, Francisco Yuri B. Macedo, Melissa Nolan Garcia, Daniel C. Garcia, Alexandre M. Benjo, David Aguilar, Hani Jneid, Biykem Bozkurt Tags: Clinical Investigation Source Type: research

Rivaroxaban for treatment of intraventricular thrombus in Chagas disease
We present a case of a 61-year-old man admitted for stroke 5 months after a renal embolism. An intraventricular thrombus was observed, probably the source of the cerebral and renal embolisms. The patient refused warfarin and rivaroxaban was used instead. After 40 days of treatment the thrombus had dissolved, after 20 months of regular use of rivaroxaban no more embolic events were observed. The use of rivaroxaban was effective in preventing embolic events in Chagas disease and intraventricular thrombus. <Learning objective: Warfarin is recommended for stroke prevention in patients with Chagas disease and left ventri...
Source: Journal of Cardiology Cases - January 12, 2016 Category: Cardiology Source Type: research

Chagas heart disease: An overview of diagnosis, manifestations, treatment, and care
We describe the clinical manifestations, diagnosis and classification criteria, risk stratification, and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments.PMID:35070110 | PMC:PMC8716970 | DOI:10.4330/wjc.v13.i12.654
Source: World Journal of Cardiology - January 24, 2022 Category: Cardiology Authors: Roberto M Saraiva Mauro Felippe F Mediano Fernanda Sns Mendes Gilberto Marcelo Sperandio da Silva Henrique H Veloso Luiz Henrique C Sangenis Paula Simpl ício da Silva Flavia Mazzoli-Rocha Andr éa S Sousa Marcelo T Holanda Alejandro M Hasslocher-Moreno Source Type: research

Prevalence and Risk Factors of Embolic Cerebrovascular Events Associated With Chagas Heart Disease
Conclusions In a selected population referred to a tertiary center for Chagas disease that included patients with different severities of cardiac involvement, the prevalence of ICE was 20%. The presence of apical aneurysm and intracavitary thrombus were independently associated with ICE, after adjustment for other risk factors for stroke.
Source: Global Heart - September 28, 2015 Category: Cardiology Source Type: research

Chagas disease as a cause of heart failure and ventricular arrhythmias in patients long removed from endemic areas: an emerging problem in Europe
We report two examples of Chagas cardiomyopathy in South American women permanently residing in Italy for more than 20 years, presenting with cardiac manifestations ranging from left ventricular dysfunction and heart failure to isolated ventricular arrhythmias. The present review emphasizes that Chagas disease should be considered as a potential diagnosis in patients from endemic areas presenting with ‘idiopathic’ cardiac manifestations, even when long removed from their country of origin, with potential implications for treatment and control of Chagas disease transmission.
Source: Journal of Cardiovascular Medicine - October 30, 2015 Category: Cardiology Tags: Arrhythmias Source Type: research

Developments in the management of Chagas cardiomyopathy.
Authors: Tanowitz HB, Machado FS, Spray DC, Friedman JM, Weiss OS, Lora JN, Nagajyothi J, Moraes DN, Garg NJ, Nunes MC, Ribeiro AL Abstract Over 100 years have elapsed since the discovery of Chagas disease and there is still much to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs available, such as benznidazole and nifurtimox, they are not totally reliable and often toxic. A recently released negative clinical trial with benznidazole in patients with chronic Chagas cardiomyopathy further reinforces the concerns regarding its effectiveness. New drugs and new delivery systems, incl...
Source: Expert Review of Cardiovascular Therapy - February 17, 2016 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

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