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Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation
ConclusionsOur results demonstrate thatH. pylori VacA antibody is the only causal determinant associated with the risk of stroke in the spectrum ofH. pylori-related antibodies, in which CRP may mediate the association. This study suggests that inhibition of the CRP signaling pathway may reduce the risk of stroke in patients with VacA-positiveH. pylori infection.
Source: Inflammation Research - May 15, 2023 Category: Research Source Type: research

Helicobacter pylori infection and prevalence of stroke
ConclusionsThe results support the premise that stroke may be associated with a history ofH  pylori infection.
Source: Helicobacter - November 15, 2018 Category: Gastroenterology Authors: Tali Shindler ‐Itskovitch, Gabriel Chodick, Varda Shalev, Khitam Muhsen Tags: ORIGINAL ARTICLE Source Type: research

What Your Blood Type Means For Your Health
ImageContent(5627c16ae4b08589ef4a227d,5627c0981400006f003c8c87,Image,HectorAssetUrl(5627c0981400006f003c8c87,Some(crop_29_110_3211_2335),Some(jpeg)),AlexRaths via Getty Images,) EmbedContent(5627c16ae4b08589ef4a227e,SPECIAL FROM ,Embed,html,Some({})) Quick: What’s your blood type? If you’re scratching your head, you may be missing out on an important health clue. A spate of recent research suggests that your blood type—whether A, B, AB, or O—may influence your risk for a variety of health conditions, from cardiac disease to cancer.   The research is still early and scientists aren’t yet s...
Source: Healthy Living - The Huffington Post - October 25, 2015 Category: Consumer Health News Source Type: news

Metabolic consequences of Helicobacter pylori infection and eradication.
Abstract Helicobacter pylori (H. pylori) is still the most prevalent infection of the world. Colonization of the stomach by this agent will invariably induce chronic gastritis which is a low-grade inflammatory state leading to local complications (peptic ulcer, gastric cancer, lymphoma) and remote manifestations. While H. pylori does not enter circulation, these extragastric manifestations are probably mediated by the cytokines and acute phase proteins produced by the inflammed mucosa. The epidemiologic link between the H. pylori infection and metabolic changes is inconstant and controversial. Growth delay was des...
Source: World Journal of Gastroenterology : WJG - May 14, 2014 Category: Gastroenterology Authors: Buzás GM Tags: World J Gastroenterol Source Type: research

Estimates of benefits and harms of prophylactic use of aspirin in the general population
Conclusions Prophylactic aspirin use for a minimum of 5 years at doses between 75 and 325 mg/day appears to have favourable benefit–harm profile; longer use is likely to have greater benefits. Further research is needed to determine the optimum dose and duration of use, to identify individuals at increased risk of bleeding, and to test effectiveness of Helicobacter pylori screening–eradication before starting aspirin prophylaxis.
Source: Annals of Oncology - December 17, 2014 Category: Cancer & Oncology Authors: Cuzick, J., Thorat, M. A., Bosetti, C., Brown, P. H., Burn, J., Cook, N. R., Ford, L. G., Jacobs, E. J., Jankowski, J. A., La Vecchia, C., Law, M., Meyskens, F., Rothwell, P. M., Senn, H. J., Umar, A. Tags: reviews Source Type: research

Nonsteroidal Anti-inflammatory Drug and Aspirin-induced Peptic Ulcer Disease.
Abstract Despite decreasing Helicobacter pylori prevalence, the prevalence of peptic ulcer disease is increasing in the aged population, mainly due to increasing use of NSAIDs to manage pain and inflammation. In addition, low dose aspirin is employed as an anti-coagulant for those who have suffered or are at high risk of ischemic stroke and cardiovascular disease. However, NSAIDs and aspirin are injurious to mucosa of stomach and duodenum. NSAID-induced inhibition of mucosal prostaglandin synthesis is thought to be a major mechanism of gastrointestinal mucosal injury. The proportion of elderly has increased rapidl...
Source: Korean J Gastroenter... - June 19, 2016 Category: Gastroenterology Authors: Shim YK, Kim N Tags: Korean J Gastroenterol Source Type: research

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers.
Conclusions. Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H. pylori infection. PMID: 27579036 [PubMed]
Source: Gastroenterology Research and Practice - September 2, 2016 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research