Filtered By:
Source: Advances in Experimental Medicine and Biology

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 185 results found since Jan 2013.

Clinical Evidence of Exercise Benefits for Stroke.
Authors: Han P, Zhang W, Kang L, Ma Y, Fu L, Jia L, Yu H, Chen X, Hou L, Wang L, Yu X, Kohzuki M, Guo Q Abstract Even though stroke is the third, not the first, most common cause of disability-adjusted life years in developed countries, it is one of the most expensive to treat. Part of the expense is due to secondary problems in the post-stroke period including: cognition, memory, attention span, pain, sensation loss, psychological issues, and problems with mobility and balance. Research has identified that exercise has both positive physical and psychosocial effects for post-stroke patients. Therefore, this scient...
Source: Advances in Experimental Medicine and Biology - November 5, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Hypertension and Exercise Training: Evidence from Clinical Studies.
Authors: Moraes-Silva IC, Mostarda CT, Silva-Filho AC, Irigoyen MC Abstract Hypertension is a worldwide prevalent disease, mostly manifested as its primary ethiology, characterized by a chronic, multifactorial, asymptomatic, and usually incurable state. It is estimated that more than one billion of the world population is hypertensive. Also, hypertension is the main cause of the two most frequent causes of death worldwide: myocardial infarction and stroke. Due to the necessity of the cardiovascular system to manage chronically increased levels of blood pressure, hypertension causes severe alterations in multiple or...
Source: Advances in Experimental Medicine and Biology - November 5, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Benefits of Exercise Training on Aerobic Capacity in Patients with Heart Failure and Preserved Ejection Fraction.
Authors: do Prado DML, Rocco EA Abstract Heart failure with preserved ejection fraction (HFpEF) is defined as an inability of the ventricles to optimally accept blood from atria with blunted end- diastolic volume response by limiting the stroke volume and cardiac output. The HEpEF prevalence is higher in elderly and women and may be associated to hypertension, diabetes mellitus and atrial fibrillation. Severe exercise intolerance, manifested by dyspnea and fatigue during physical effort is the important chronic symptom in HFpEF patients, in which is the major determinant of their reduced quality of life. In this se...
Source: Advances in Experimental Medicine and Biology - November 5, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Combination of Hydralazine and Isosorbide-Dinitrate in the Treatment of Patients with Heart Failure with Reduced Ejection Fraction.
Authors: Nyolczas N, Dékány M, Muk B, Szabó B Abstract The use of direct acting vasodilators (the combination of hydralazine and isosorbide dinitrate -Hy+ISDN-) in heart failure with reduced ejection fraction (HFrEF) is supported by evidence, but rarely used.However, treatment with Hy+ISDN is guideline-recommended for HFrEF patients who cannot receive either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers due to intolerance or contraindication, and in self-identified African-American HFrEF patients who are symptomatic despite optimal neurohumoral therapy.The Hy+ISDN combination has arte...
Source: Advances in Experimental Medicine and Biology - November 2, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension.
Authors: Barman SA, Fulton D Abstract Pulmonary arterial hypertension (PAH) is a progressive disease arising from remodeling and narrowing of pulmonary arteries (PA) resulting in high pulmonary arterial blood pressure and ultimately right ventricular failure. Elevated production of reactive oxygen species (ROS) by NADPH oxidase 4 (Nox4), a constitutively active enzyme, has been associated with oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis. Further, elevated expression of Nox4 has been reported in a number of cardiovascular di...
Source: Advances in Experimental Medicine and Biology - October 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Applications for Electrical Impedance Tomography (EIT) and Electrical Properties of the Human Body.
In conclusion, Electrical Impedance Tomography is a promising method for the development of noninvasive diagnostic medicine, since it is able to provide imaging of the interior of the human body in real time without causing harm or putting the human body in risk. PMID: 28971420 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - October 4, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Disease.
Authors: Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H Abstract Mesenchymal stem cells (MSCs) are multipotent stem cells that reside in various organs. They have the capacity to differentiate into various cell types, including cardiomyocytes, vascular endothelial cells, and vascular smooth muscle cells. Among the various MSCs, bone marrow-derived MSCs (BMMSCs) have been widely used for treating acute myocardial infarction (AMI) and ischemic heart failure (IHF) in preclinical and clinical studies. Although the beneficial effects of BMMSCs in treating AMI and IHF were originally attributed to their capacity to...
Source: Advances in Experimental Medicine and Biology - September 24, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Exosomes-Based Biomarkers for the Prognosis of Cardiovascular Diseases.
Authors: Bei Y, Yu P, Cretoiu D, Cretoiu SM, Xiao J Abstract Cardiovascular diseases (CVDs) have a high prevalence and annually increasing incidence with high mortality and morbidity. Identification of biomarkers with high sensitivity and specificity for assessing the prognosis of CVDs is necessary for optimizing personalized treatment and reducing mortality. Exosomes have been proved to be accessible in nearly all body fluids and they can reflect disease stage or progression. Here we summarized exosomes-based biomarkers for the prognosis of coronary artery diseases, heart failure, stroke, hypertension, cardiac arr...
Source: Advances in Experimental Medicine and Biology - September 24, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Structure, Pharmacology and Roles in Physiology of the P2Y12 Receptor.
Authors: von Kügelgen I Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y12 receptor is an important target in pharmacotherapy. The receptor couples to Gαi2 mediating an inhibition of cyclic AMP accumulation and additional downstream events including the activation of phosphatidylinositol-3-kinase and Rap1b proteins. The nucleoside analogue ticagrelor and active metabolites of the thienopyridine compounds ticlopidine, clopidogrel and prasugrel block P2Y12 receptors and, thereby, inhibit ADP-induced platelet aggreg...
Source: Advances in Experimental Medicine and Biology - September 20, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Analysis of Neuroprotection by Taurine and Taurine Combinations in Primary Neuronal Cultures and in Neuronal Cell Lines Exposed to Glutamate Excitotoxicity and to Hypoxia/Re-oxygenation.
Authors: Prentice H, Pan C, Gharibani PM, Ma Z, Price AL, Giraldo GS, Retz HM, Gupta A, Chen PC, Chiu H, Modi J, Menzie J, Tao R, Wu JY Abstract Ischemic stroke is one of the greatest contributors to death and long term disability in developed countries. Ischemia induced brain injury arises due to excessive release of glutamate and involves cell death due to apoptosis and endoplasmic reticulum (ER) stress responses. Despite major research efforts there are currently no effective treatments for stroke. Taurine, a free amino acid found in high concentrations in many invertebrate and vertebrate systems can provide pro...
Source: Advances in Experimental Medicine and Biology - August 31, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Neuroprotective Functions Through Inhibition of ER Stress by Taurine or Taurine Combination Treatments in a Rat Stroke Model.
Authors: Prentice H, Gharibani PM, Ma Z, Alexandrescu A, Genova R, Chen PC, Modi J, Menzie J, Pan C, Tao R, Wu JY Abstract Taurine, as a free amino acid, is found at high levels in many tissues including brain, heart and skeletal muscle and is known to demonstrate neuroprotective effects in a range of disease conditions including stroke and neurodegenerative disease. Using in vitro culture systems we have demonstrated that taurine can elicit protection against endoplasmic reticulum stress (ER stress) from glutamate excitotoxicity or from excessive reactive oxygen species in PC12 cells or rat neuronal cultures. In o...
Source: Advances in Experimental Medicine and Biology - August 31, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Taurine Chloramine Prevents Neuronal HT22 Cell Damage Through Nrf2-Related Heme Oxygenase-1.
Authors: Cheong SH, Lee DS Abstract Oxidative cell damages are able to contribute to neuronal degeneration in several diseases of the central nervous system (CNS) including stroke as well as ischemia. Heme oxygenase (HO)-1 plays a major role in the pathogenesis of neuronal disorder. Taurine chloramine (TauCl) has been shown to possess strong neuronal activities; however, the direct effects of TauCl on neuronal cell death remain to be determined. Therefore, this study was designed to assess the neuroprotective effect of TauCl using oxidative stress-stimulated mouse hippocampal HT22 cells. TauCl showed protective eff...
Source: Advances in Experimental Medicine and Biology - August 31, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Role of Nitric Oxide from Neurological Disease to Cancer.
Authors: Maher A, Abdel Rahman MF, Gad MZ Abstract Until the beginning of the 1980s, nitric oxide (NO) was just a toxic molecule of a lengthy list of environmental pollutants such as cigarette smoke and smog. In fact, NO had a very bad reputation of being destroyer of ozone, suspected carcinogen and precursor of acid rain. However, by the early 1990s it was well recognized by the medical research community. Over the last two decades, the picture has been totally changed. Diverse lines of evidence have converged to show that this sometime poison is a fundamental player in the everyday business of the human body. NO ...
Source: Advances in Experimental Medicine and Biology - August 27, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have been shown to overcome the foreign body response for long-term sensing. The sensors are engineered to change luminescence in the presence of oxygen or other analytes and function for months to years in the body. A single injection followed by non-invasive monitoring with a hand-held or wearable Bluetooth optical reader enables intermittent or continuous measurements. Proof of concept for applicatio...
Source: Advances in Experimental Medicine and Biology - July 9, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Effects of Motor Imagery on Cognitive Function and Prefrontal Cortex Activity in Normal Adults Evaluated by NIRS.
Authors: Moriya M, Sakatani K Abstract Recent near-infrared spectroscopy (NIRS) studies demonstrated that physical exercise enhances working memory (WM) performance and prefrontal cortex (PFC) activity during WM tasks in normal adults. Interestingly, the effects of rehabilitation (i.e. physiotherapy) on post-stroke patients could be enhanced by motor imagery (MI), an active process during which the specified action is reproduced within WM without any actual physical movement. However, it is not known whether MI can enhance cognitive function and associated brain activity. To clarify these issues, we evaluated the e...
Source: Advances in Experimental Medicine and Biology - July 9, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research