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Source: Advances in Experimental Medicine and Biology

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Total 185 results found since Jan 2013.

Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial
Adv Exp Med Biol. 2021;1308:579-588. doi: 10.1007/978-3-030-64872-5_28.ABSTRACTAnti-arrhythmic agents, like amiodarone, interfere at different stages of the ischemic stroke. However, amiodarone was accompanied with immunological pulmonary complications and adverse neurological effects. We hypothesize that magnesium sulfate in combination with amiodarone holds promise for stroke treatment. Thirty-six patients with confirmed diagnosis of ischemic stroke and atrial fibrillation who received bolus amiodarone were randomly assigned to magnesium sulfate every 24 h or similar volume of normal saline (as placebo) for 5 days. Vario...
Source: Advances in Experimental Medicine and Biology - April 16, 2021 Category: Research Authors: Yunes Panahi Mojtaba Mojtahedzadeh Atabak Najafi Mohammadreza Gheini Mohammad Abdollahi Mohammad Sharifzadeh Arezoo Ahmadi Shiva Ganjali Seyyed Mahdi Rajaee George E Barreto Amirhossein Sahebkar Source Type: research

Mini Craniotomy in the Management of Supratentorial Spontaneous Intracranial Hemorrhage: A Single-Center Outcome of the Minimally Invasive Treatment
Adv Exp Med Biol. 2021 Mar 14. doi: 10.1007/5584_2021_632. Online ahead of print.ABSTRACTHemorrhagic stroke accounts for a significant proportion of mortality and confers a poor quality of life with high dependency among survivors. Surgical evacuation of hematoma has the advantage of rapidly controlling the increased intracranial pressure, halting the ongoing herniation syndrome, and mitigating the secondary cascades of events mediated by the inflammatory and blood degradation products. The advantage is hindered by the concurrent insult to the healthy brain tissue while passing through the normal brain tissue. Therefore, m...
Source: Advances in Experimental Medicine and Biology - March 13, 2021 Category: Research Authors: Binod Bhattarai Aliza Bajracharya Suja Gurung Sweta Giri Sashi Bhusan Sah Sunil Munakomi Source Type: research

Neurological Complications of the COVID-19 Pandemic: What Have We Got So Far?
Adv Exp Med Biol. 2021;1321:21-31. doi: 10.1007/978-3-030-59261-5_2.ABSTRACTThe recently emerged coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, is the newest threat to human health. It has already infected more than 54.5 million people worldwide, currently leading to more than 1.3 million deaths. Although it causes a mild flu-like disease in most patients, lethality may increase to more than 20% in elderly subjects, especially in those with comorbidities, like hypertension, diabetes, or lung and cardiac disease, and the mechanisms are still elusive. Common symp...
Source: Advances in Experimental Medicine and Biology - March 3, 2021 Category: Research Authors: Isabelle Pastor Bandeira Marco Ant ônio Machado Schlindwein Leticia Caroline Breis Jean Pierre Schatzmann Peron Marcus Vin ícius Magno Gonçalves Source Type: research

N-Methyl-D-Aspartate Receptor Signaling-Protein Kinases Crosstalk in Cerebral Ischemia.
Authors: Engin A, Engin AB Abstract Although stroke is very often the cause of death worldwide, the burden of ischemic and hemorrhagic stroke varies between regions and over time regarding differences in prognosis, prevalence of risk factors, and treatment strategies. Excitotoxicity, oxidative stress, dysfunction of the blood-brain barrier, neuroinflammation, and lysosomal membrane permeabilization, sequentially lead to the progressive death of neurons. In this process, protein kinases-related checkpoints tightly regulate N-methyl-D-aspartate (NMDA) receptor signaling pathways. One of the major hallmarks of cerebra...
Source: Advances in Experimental Medicine and Biology - February 6, 2021 Category: Research Tags: Adv Exp Med Biol Source Type: research

A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review.
Authors: Park YJ, Farooq J, Cho J, Cozene B, Gonzales-Portillo B, Sadanandan N, Saft M, Lee JY, Borlongan CV Abstract Stem cell-based therapy stands as a robust experimental treatment for ischemic stroke. Stem cells derived from fetal, embryonic, and adult tissues serve as potential sources for transplantable cells in the setting of ischemic stroke. However, the search continues for finding an optimal cell line for clinical use. Muse cells, a distinct subset of mesenchymal stem cells found sporadically in the connective tissue of nearly every organ, may be a suitable candidate due to its safety and accessibility. T...
Source: Advances in Experimental Medicine and Biology - November 11, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research