Taurine Chloramine Prevents Neuronal HT22 Cell Damage Through Nrf2-Related Heme Oxygenase-1.

Taurine Chloramine Prevents Neuronal HT22 Cell Damage Through Nrf2-Related Heme Oxygenase-1. Adv Exp Med Biol. 2017;975:145-157 Authors: Cheong SH, Lee DS Abstract Oxidative cell damages are able to contribute to neuronal degeneration in several diseases of the central nervous system (CNS) including stroke as well as ischemia. Heme oxygenase (HO)-1 plays a major role in the pathogenesis of neuronal disorder. Taurine chloramine (TauCl) has been shown to possess strong neuronal activities; however, the direct effects of TauCl on neuronal cell death remain to be determined. Therefore, this study was designed to assess the neuroprotective effect of TauCl using oxidative stress-stimulated mouse hippocampal HT22 cells. TauCl showed protective effects against oxidative stress-induced neurotoxicity and inhibited the reactive oxygen species (ROS) production by inducing the heme oxygenase (HO)-1 expression in HT22 cells. TauCl upregulated HO-1 expression and it also increased the nuclear factor E2-related factor 2 (Nrf2) translocation to nuclear. Using an inhibitor of HO-1 activity, we verified that the oxidative stress-related HT22 cell death was significantly suppressed by TauCl. In addition, we found reduced TauCl-induced HO-1 expression and cytoprotection following treatment of the cells with an extracellular signal-regulated kinase (ERK) inhibitor (PD98059) or a p38 inhibitor (SB203580), but not following treatment with a SP600125 as a c-...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research