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Source: Translational Stroke Research
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Total 861 results found since Jan 2013.
Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol
AbstractAneurysmal subarachnoid haemorrhage (aSAH) results in persistent clinical deficits which prevent survivors from returning to normal daily functioning. Only a small fraction of the variation in clinical outcome following aSAH is explained by known clinical, demographic and imaging variables; meaning additional unknown factors must play a key role in clinical outcome. There is a growing body of evidence that genetic variation is important in determining outcome following aSAH. Understanding genetic determinants of outcome will help to improve prognostic modelling, stratify patients in clinical trials and target novel...
Source: Translational Stroke Research - January 6, 2022 Category: Neurology Source Type: research
Ultrasound-Induced Release of Nimodipine from Drug-Loaded Block Copolymer Micelles: In Vivo Analysis
In this study, we aimed to assess the concept of controlled drug release from nimodipine-loaded copolymers by ultrasound application in the chicken chorioallantoic membrane (CAM) model. Nimodipine-loaded copolymers were produced with the direct dissolution method. Vasospasm of the CAM vessels was induced by means of ultrasound (Physiomed, continuous wave, 3 MHz, 1.0 W/cm2). The ultrasound-mediated nimodipine release (Physiomed, continuous wave, 1 MHz, 1.7 W/cm2) and its effect on the CAM vessels were evaluated. Measurements of vessel diameter before and after ultrasound-induced nimodipine release were performed using...
Source: Translational Stroke Research - January 5, 2022 Category: Neurology Source Type: research
The Top 100 Cited Articles Published in Translational Stroke Research
Source: Translational Stroke Research - December 2, 2021 Category: Neurology Source Type: research
Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Adults with Moyamoya Disease
In conclusion, this study provided a novel and potential framework for the practical assessment of MMD by magnetic resonance imaging.
Source: Translational Stroke Research - November 28, 2021 Category: Neurology Source Type: research
Correction to: RNF213 p.Arg4810Lys Heterozygosity in Moyamoya Disease Indicates Early Onset and Bilateral Cerebrovascular Events
Source: Translational Stroke Research - November 26, 2021 Category: Neurology Source Type: research
Collateral Supply in Preclinical Cerebral Stroke Models
AbstractEnhancing the collateral blood supply during the acute phase of cerebral ischemia may limit both the extension of the core infarct, by rescuing the penumbra area, and the degree of disability. Many imaging techniques have been applied to rodents in preclinical studies, to evaluate the magnitude of collateral blood flow and the time course of responses during the early phase of ischemic stroke. The collateral supply follows several different routes at the base of the brain (the circle of Willis) and its surface (leptomeningeal or pial arteries), corresponding to the proximal and distal collateral pathways, respectiv...
Source: Translational Stroke Research - November 19, 2021 Category: Neurology Source Type: research
Carboxypeptidase U (TAFIa) Is Rapidly Activated and Deactivated Following Thrombolysis and Thrombectomy in Stroke Patients
AbstractThe antifibrinolytic enzyme carboxypeptidase U (CPU, TAFIa, CPB2) is an appealing target for the treatment of acute ischemic stroke (AIS). Increased insights in CPU activation and inactivation during thrombolysis (rtPA) with or without endovascular thrombectomy (EVT) are required to develop CPU inhibitors as profibrinolytic agents with optimal benefits/risks. Therefore, CPU kinetics during ischemic stroke treatment were evaluated. AIS patients with documented cerebral artery occlusion receiving rtPA (N = 20) or rtPA + EVT (N = 16) were included. CPU activation during thrombolysis was measured by an ultr...
Source: Translational Stroke Research - November 19, 2021 Category: Neurology Source Type: research
MicroRNA miR-21 Decreases Post-stroke Brain Damage in Rodents
AbstractDue to their role in controlling translation, microRNAs emerged as novel therapeutic targets to modulate post-stroke outcomes. We previously reported that miR-21 is the most abundantly induced microRNA in the brain of rodents subjected to preconditioning-induced cerebral ischemic tolerance. We currently show that intracerebral administration of miR-21 mimic decreased the infarct volume and promoted better motor function recovery in adult male and female C57BL/6 mice subjected to transient middle cerebral artery occlusion. The miR-21 mimic treatment is also efficacious in aged mice of both sexes subjected to focal i...
Source: Translational Stroke Research - November 18, 2021 Category: Neurology Source Type: research
Medical and Endovascular Treatments for Intracranial Atherosclerotic Stenosis: A Network Meta-Analysis
AbstractMedical treatment and endovascular therapy are widely used for intracranial atherosclerotic stenosis, but the best treatment strategy remains uncertain. The goal of this study was to compare the safety and effectiveness of medical treatment, stenting, and primary balloon angioplasty (PBA). We searched PubMed, MEDLINE, and EMBASE for trials comparing these three treatments for intracranial stenosis up to December 24, 2020. We performed a network meta-analysis with random-effects models. The primary outcome was any stroke or death during a long-term follow-up. Secondary outcomes included ischemic stroke, intracranial...
Source: Translational Stroke Research - November 18, 2021 Category: Neurology Source Type: research
Contribution of Endoplasmic Reticulum Stress to the Clinical Instability of Carotid Plaques in Human Carotid Stenosis
AbstractEndoplasmic reticulum (ER) stress is an important process during the progression of atherosclerosis. The aim of this study was to elucidate the association of ER stress and clinical instability of carotid plaque. One hundred ninety-three patients with carotid stenosis undergoing carotid endarterectomies (CEAs) were enrolled. We classified the patients into 3 groups: the asymptomatic, symptomatic, and cTIA (crescendo transient ischemic attack)/SIE (stroke in evolution) groups. Immunohistological staining was performed to assess ER stress and apoptosis. The correlation between ER stress marker expression and clinical...
Source: Translational Stroke Research - November 16, 2021 Category: Neurology Source Type: research
Response to Letter to Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy
Source: Translational Stroke Research - November 15, 2021 Category: Neurology Source Type: research
Correction to: Extracellular Vesicles Derived from Neural Progenitor Cells ––a Preclinical Evaluation for Stroke Treatment in Mice
Source: Translational Stroke Research - November 9, 2021 Category: Neurology Source Type: research
Mitochondrial-Based Therapeutic Strategies for Intracerebral Hemorrhage
Source: Translational Stroke Research - November 6, 2021 Category: Neurology Source Type: research
Correction to: Erythropoietin Abrogates Post-ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner
Source: Translational Stroke Research - November 6, 2021 Category: Neurology Source Type: research
Relation of Carotid Plaque Features Detected with Ultrasonography-Based Radiomics to Clinical Symptoms
AbstractCarotid plaque is one of the predominant causes of stroke. We sought to build a nomogram using ultrasonography (US)-based radiomics and clinical features for identification of symptomatic carotid plaques. We prospectively enrolled 548 patients (mean age ± standard deviation, 63 ± 10 years; 373 men) were randomly divided into training and test cohorts. Clinical and conventional US features of carotid plaques were used to generate a clinical and conventional US model. US-based radiomics model was constructed by extracting radiomics featur es from grayscale and strain elasticity images. Multivariate logist...
Source: Translational Stroke Research - November 6, 2021 Category: Neurology Source Type: research
