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Source: Neurochemical Research
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Total 300 results found since Jan 2013.
Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective
Neurochem Res. 2022 Jan 7. doi: 10.1007/s11064-021-03500-0. Online ahead of print.ABSTRACTCerebral ischemia is one of the most devastating brain injuries and a primary cause of acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at both the experimental and clinical levels, options for stroke-related brain injury are still limited. Several evidence suggests that autophagy is triggered in response to cerebral ischemia, therefore targeting autophagy-related signaling pathways can provide a new direction for the therapeutic implications in the ischemic injury. Autophagy is a highly conserve...
Source: Neurochemical Research - January 7, 2022 Category: Neuroscience Authors: Palak Kalra Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Neuropeptide α-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes
In conclusion, α-MSH is neuroprotective under hyperglycemic condition against I/R induced brain damage by its anti-inflammatory, anti-oxidative and anti-apoptotic properties. The use of α-MSH analogues may be potential therapeutic agents for diabetic stroke.PMID:34586586 | DOI:10.1007/s11064-021-03453-4
Source: Neurochemical Research - September 29, 2021 Category: Neuroscience Authors: Rajesh Kumar Goit Tsz Chung Ng Ka Cheung Tam Jessica K W Tsang Andrew W Taylor Amy C Y Lo Source Type: research
Medicarpin Protects Cerebral Microvascular Endothelial Cells Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via the PI3K/Akt/FoxO Pathway: A Study of Network Pharmacology Analysis and Experimental Validation
In conclusion, medicarpin suppressed OGD/R-induced injury in HCMECs by activating PI3K/Akt/FoxO pathway.PMID:34523056 | DOI:10.1007/s11064-021-03449-0
Source: Neurochemical Research - September 15, 2021 Category: Neuroscience Authors: Yu Wang Ronggang Yang Feng Yan Yeqiang Jin Xu Liu Tiancai Wang Source Type: research
Neuroprotective Effects of Chemerin on a Mouse Stroke Model: Behavioral and Molecular Dimensions
Neurochem Res. 2021 Aug 24. doi: 10.1007/s11064-021-03432-9. Online ahead of print.ABSTRACTThe present study was conducted to investigate the effects of different doses of recombinant human Chemerin (rhChemerin) on brain damage, spatial memory, blood-brain barrier (BBB) disruption and cellular and molecular mechanisms in a mouse stroke model. The mouse stroke model was developed by blocking the middle cerebral artery for 1 h and performing reperfusion for 23 h. Immediately, one and three hours after the stroke, 200, 400 and 800 ng/mouse of intranasal rhChemerin was administered. Neuronal and BBB damage, spatial memory and ...
Source: Neurochemical Research - August 25, 2021 Category: Neuroscience Authors: Azam Abareshi Shahein Momenabadi Abbas Ali Vafaei Ahmad Reza Bandegi Abedin Vakili Source Type: research
Correction to: miR ‑671‑5p Attenuates Neuroinflammation via Suppressing NF‑κB Expression in an Acute Ischemic Stroke Model
Neurochem Res. 2021 Aug 12. doi: 10.1007/s11064-021-03421-y. Online ahead of print.NO ABSTRACTPMID:34383251 | DOI:10.1007/s11064-021-03421-y
Source: Neurochemical Research - August 12, 2021 Category: Neuroscience Authors: Ling Deng Yi Guo Jingdong Liu Xuan Wang Sha Chen Qian Wang Jianyan Rao Yuchun Wang Tianrui Zuo Qingwen Hu Xiahong Zhao Zhi Dong Source Type: research
Autophagy Inhibition by ATG3 Knockdown Remits Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury and Inflammation in Brain Microvascular Endothelial Cells
In conclusion, autophagy inhibition by ATG3 knockdown remitted OGD/R-induced injury and inflammation in brain microvascular endothelial cells via activation of the PI3K/Akt pathway.PMID:34379294 | DOI:10.1007/s11064-021-03423-w
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Zhaolong Peng Daofei Ji Lukuan Qiao Yuedong Chen Hongjuan Huang Source Type: research
