Filtered By:
Source: Neurochemical Research
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 300 results found since Jan 2013.
< sup > 1 < /sup > H NMR Spectroscopy-Based Metabolomics Approach to Study the Anti-Stroke Activity of G-3702, a Novel Better Alternative to DL-3-n-Butylphthalide
Neurochem Res. 2022 Jun 23. doi: 10.1007/s11064-022-03648-3. Online ahead of print.ABSTRACTCerebrovascular disease is the leading cause of disability and death, and ischemic stroke accounts for most stroke cases. However, few effective drugs are available for the treatment of ischemic stroke; thus, there is an urgent need to develop effective drugs to treat ischemic stroke. DL-3-n-butylphthalide (NBP) is clinically approved as an anti-ischemic drug in China, but its potential hepatotoxicity limits its use. G-3702 (a structural analogue of NBP) is synthesized with the boron hydroxyl group replacing carbonyl group. G-3702 si...
Source: Neurochemical Research - June 23, 2022 Category: Neuroscience Authors: Guanghui Li Lingyu Ruan Huihui Meng Wenya Liu Xinyu Zhong Jinran Yu Lin Zhang Minqiang Zhu Junsong Wang Source Type: research
Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research
Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke
Neurochem Res. 2022 Jun 6. doi: 10.1007/s11064-022-03638-5. Online ahead of print.ABSTRACTIschemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke are hardly recovered because of the limited regenerative properties. However, recent rodent intervention studies manipulating the extracellular environments at the subacute phase shed new light on the regenerative potency of the injured brain. This review introduces the rational design of artificial extracellular matrix (ECM) mimics using supramolecular peptidic scaffo...
Source: Neurochemical Research - June 6, 2022 Category: Neuroscience Authors: Takahiro Muraoka Itsuki Ajioka Source Type: research
Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPAR γ Pathway
This study aims to explore the regulatory effects of ginkgetin on microglia polarization in brain ischemia. Oxygen glucose deprivation (OGD) cellular model and middle cerebral artery occlusion (MCAO) animal model was used in this study. We first observed the dynamic process of microglia polarization in ischemic stroke, and then investigated the effect of ginkgetin treatment on microglia polarization. Finally, we studied the role of PPARγ signaling pathway and the blocking effect of PPARγ antagonist GW9662 in this process. OGD and cerebral ischemia polarized microglia mainly to M1 type. However, ginkgetin treatment conver...
Source: Neurochemical Research - May 20, 2022 Category: Neuroscience Authors: Tianchi Tang Xiongwei Wang Enbo Qi Shiting Li Hui Sun Source Type: research
MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF- κB Axis
Neurochem Res. 2022 May 10. doi: 10.1007/s11064-022-03597-x. Online ahead of print.ABSTRACTIschemic stroke is a grievous intimidation to the healthiness of sufferers. Previous studies have reported that dexmedetomidine (DEX) has a protective effect on a variety of organs. This paper aimed to explore the regulatory mechanism of DEX in ischemic stroke through miR-665/ROCK2 axis. The mice model of ischemic stroke was constructed by middle cerebral artery occlusion (MCAO). The cell model of ischemic stroke was constructed by oxygen-glucose deprivation (OGD). Cell viability and apoptosis were assessed by CCK-8 assay and flow cy...
Source: Neurochemical Research - May 10, 2022 Category: Neuroscience Authors: QiongHua Liu JianE Wu ShangShu Lai Gan Li Source Type: research
Kaempferol Mediated AMPK/mTOR Signal Pathway Has a Protective Effect on Cerebral Ischemic-Reperfusion Injury in Rats by Inducing Autophagy
Neurochem Res. 2022 May 7. doi: 10.1007/s11064-022-03604-1. Online ahead of print.ABSTRACTIschemia/reperfusion (I/R) caused by ischemic stroke treatments leads to brain injury and its pathological mechanism is related to autophagy. The underlying mechanism of kaempferol on cerebral I/R injury needs to be explored. To establish I/R injury, we used a middle cerebral artery occlusion-reperfusion (MCAO) model in rats. MCAO rats were treated with the same amount of saline (I/R group); Treatment group rats were treated orally with kaempferol (50, 100, 200 mg/kg) for 7 days before surgery. After reperfusion for 24 h, the scores o...
Source: Neurochemical Research - May 7, 2022 Category: Neuroscience Authors: Yajing Yuan Fei Xia Rong Gao Yang Chen Yu Zhang Zhongping Cheng Hongwei Zhao Liming Xu Source Type: research
Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats
Neurochem Res. 2022 Apr 25. doi: 10.1007/s11064-022-03596-y. Online ahead of print.ABSTRACTPost-stroke depression (PSD) is the most common mental disorder in stroke survivors. However, its specific pathophysiology remains largely unknown. Previous studies suggested a role of hippocampus in PSD. Therefore, we conducted this study to investigate the lipid metabolic signatures in hippocampus of PSD rats. Here, the liquid chromatography mass spectrometry was used to identify the lipid metabolic signatures in the hippocampus of PSD, control and stroke rats. Then, correlations between behavior indices and differential lipid meta...
Source: Neurochemical Research - April 26, 2022 Category: Neuroscience Authors: Wenxia Jiang Jianjun Chen Lei Gong Fang Liu Huan Zhao Jun Mu Source Type: research
