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Source: Neurochemical Research
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Total 300 results found since Jan 2013.
Autophagy Inhibition by ATG3 Knockdown Remits Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury and Inflammation in Brain Microvascular Endothelial Cells
In conclusion, autophagy inhibition by ATG3 knockdown remitted OGD/R-induced injury and inflammation in brain microvascular endothelial cells via activation of the PI3K/Akt pathway.PMID:34379294 | DOI:10.1007/s11064-021-03423-w
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Zhaolong Peng Daofei Ji Lukuan Qiao Yuedong Chen Hongjuan Huang Source Type: research
Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury
Neurochem Res. 2021 Aug 11. doi: 10.1007/s11064-021-03419-6. Online ahead of print.ABSTRACTIschemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset. Loss of function after stroke is due to cell death in the infarcted tissue, cell dysfunction in the peri-infarct region, as well as dysfunction and neurodegeneration in remote brain areas. Plasticity responses in spared brain regions are a major contributor to functional recovery, while secondary neurodegeneration in remote regions is associated wit...
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Marcela Pekna Anna Stokowska Milos Pekny Source Type: research
Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System
Neurochem Res. 2021 Aug 7. doi: 10.1007/s11064-021-03412-z. Online ahead of print.ABSTRACTResveratrol is a phenol compound produced by some plants in response to pathogens, infection, or physical injury. It is well-known that resveratrol has antioxidant and protective roles in damages potentially caused by cancer or other serious disorders. Thus, it is considered as a candidate agent for the prevention and treatment of human diseases. Evidence has confirmed other bioactive impacts of resveratrol, including cardioprotective, anti-tumorigenic, anti-inflammatory, phytoestrogenic, and neuroprotective effects. Ischemia-reperfus...
Source: Neurochemical Research - August 8, 2021 Category: Neuroscience Authors: Alireza Sarkaki Mojtaba Rashidi Mina Ranjbaran Aram Asareh Zadegan Dezfuli Zahra Shabaninejad Ebrahim Behzad Maryam Adelipour Source Type: research
Effects of Paired Associative Stimulation on Metabolites in Ischemia Stroke Rats Model as Studied by Nuclear Magnetic Resonance Spectrum
In this study, we employed a comprehensive battery of measurements, including behavioral test, electrophysiology and 1H-NMR approaches, to investigate the therapeutic effects of PAS in rat model of cerebral ischemia and its underlying mechanism. Rats were randomly divided into a transient middle cerebral artery occlusion group (tMCAO group), a tMCAO + PAS group (PAS group), and a sham group. PAS was applied over 7 consecutive days in PAS group. The behavioral function of rats was evaluated by modified Garcia Scores and Rota-rod test. Electrophysiological changes were measured by motor evoked potentials (MEP). Metabolic cha...
Source: Neurochemical Research - July 7, 2021 Category: Neuroscience Authors: Yan Hu Jinfeng Wu Xiangyu Zhang Jun Tian Yinshan Lu Tiecheng Guo Source Type: research
Spata2 Knockdown Exacerbates Brain Inflammation via NF- κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats
Neurochem Res. 2021 Jun 1. doi: 10.1007/s11064-021-03360-8. Online ahead of print.ABSTRACTBrain inflammation induced by ischemic stroke is an important cause of secondary brain injury. The nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and NLRP3 inflammasome signaling are believed to drive the progression of brain inflammation. Spermatogenesis-associated protein2 (SPATA2) functions as a partner protein that recruits CYLD, a negative regulator of NF-κB signaling, to signaling complexes. However, the role of SPATA2 in the central nervous system remains unclear and whether it is involved in regulat...
Source: Neurochemical Research - June 2, 2021 Category: Neuroscience Authors: Yikun Ren Jin Jiang Wenxia Jiang Xueling Zhou Wenhao Lu Jingwen Wang Yong Luo Source Type: research
Knockdown of XIST Attenuates Cerebral Ischemia/Reperfusion Injury Through Regulation of miR-362/ROCK2 Axis
In conclusion, depletion of XIST attenuated I/R-induced neurological impairment and inflammatory response via the miR-362/ROCK2 axis. These findings offer a potential novel strategy for ischemic stroke therapy.PMID:34037903 | DOI:10.1007/s11064-021-03354-6
Source: Neurochemical Research - May 26, 2021 Category: Neuroscience Authors: Jingtao Wang Zhenqiang Fu Menghan Wang Jingjing Lu Hecheng Yang Hong Lu Source Type: research
Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings
This study was designed to evaluate the underlying protective mechanisms of oleuropein involved in alleviating brain damage in a rat model of ischemic stroke. Male Wistar rats were divided into four groups; Control, stroke (MCAO), MCAO + clopidogrel (Clop) and MCAO + oleuropein (Ole). Results showed that the MCAO group evidenced significant brain edema (+ 9%) as well as increases of plasma cardiac markers such as lactate deshydrogenase (LDH), creatine kinase (CK-MB), fibrinogen and Trop-T by 11 %, 43%, 168 and 590%, respectively, as compared to the control group. Moreover, infarcted rats exhibited remarkable elevated level...
Source: Neurochemical Research - May 19, 2021 Category: Neuroscience Authors: Kais Mnafgui Lakhdar Ghazouani Raouf Hajji Abir Tlili Fatma Derbali Francisco Ivan da Silva Joabe Lima Ara újo Bianca de Oliveira Schinoff Jos é Fernando Ruggiero Bachega Ant ônia Laíres da Silva Santos Noureddine Allouche Source Type: research
