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Source: International Journal of Cardiology

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Total 880 results found since Jan 2013.

Real world long-term outcomes among adults undergoing transcatheter patent foramen closure with amplatzer PFO occluder
Patent foramen ovale (PFO) is a congenital heart defect associated with an increased risk of cryptogenic stroke. We aimed to evaluate real-world outcomes of adult patients undergoing transcatheter PFO closure with the Amplatzer PFO Occluder.
Source: International Journal of Cardiology - September 19, 2022 Category: Cardiology Authors: Lusine Abrahamyan, Madeleine Barker, Christoffer Dharma, Douglas S. Lee, Peter C. Austin, Areeba Asghar, Annamalar Muthuppalaniappan, Lee Benson, Mark Osten, Eric M. Horlick Source Type: research

Geographic variations in percutaneous versus surgical coronary revascularization: A global perspective from the SYNTAXES trial
The Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial [1] was a landmark trial published by Serruys et al. in 2009 that compared percutaneous coronary intervention (PCI) with first-generation paclitaxel-eluting stents versus coronary artery bypass grafting (CABG) among 1,800 participants with de-novo three-vessel and left main coronary artery disease. The primary endpoint of major adverse cardiac and cerebrovascular events (i.e., death, stroke, myocardial infarction, or repeat revascularization at 12 months) occurred in 17.8% of cases in the PCI group and 12.4% of cases in the CABG group (P=0.002) [1].
Source: International Journal of Cardiology - September 8, 2022 Category: Cardiology Authors: Felice Gragnano, Francesco Pelliccia, Arturo Cesaro, Paolo Calabr ò Tags: Editorial Source Type: research

Reply to “GLP1RA versus SGLT2i tended to have more favorable ischemic outcomes including stroke?”
We appreciated Du et al.'s valuable comments on our recent study. [1] As described by the author, the reduced trend of a composite ischemic outcome in the glucagon-like peptide-1 receptor agonists (GLP1RA) group, compared to the sodium-glucose cotransporter 2 inhibitors (SGLT2i) group, was mainly derived by acute coronary syndrome (ACS). However, despite the lack of statistical significance due to the low event rates, it was noted that the annualized rates (per 100 person-year) for each component of ischemic events were lower in the GLP1RA group than SGLT2i group: ACS 0.25 vs.
Source: International Journal of Cardiology - August 23, 2022 Category: Cardiology Authors: In-Chang Hwang, Chee Hae Kim Tags: Letter to the Editor Source Type: research

Utility of P-wave abnormalities for distinguishing embolic stroke from non-embolic stroke
Our aim was to analyze the incidence of P-wave abnormalities in embolic and non-embolic strokes, and evaluate its clinical usefulness for predicting stroke etiology.
Source: International Journal of Cardiology - August 22, 2022 Category: Cardiology Authors: Hidehiro Iwakawa, Ken Terata, Ryosuke Kato, Ryota Kaimori, Haruwo Tashiro, Wakana Sato, Hiroyuki Watanabe Source Type: research

Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation – Unmet clinical needs
Oral anticoagulation (OAC) is crucial to prevent cardioembolic stroke in patients with atrial fibrillation (AF). Development of the direct oral anticoagulants (DOAC), which inhibit activities of the coagulant proteases thrombin and activated factor X (FXs), has improved the safety and efficacy of anticoagulation in AF, compared to traditional vitamin K antagonists like warfarin [1,2]. Yet in a small, but numerically relevant proportion of up to 2% of patients, this cornerstone principle fails for unclear reasons.
Source: International Journal of Cardiology - August 6, 2022 Category: Cardiology Authors: Florian Bruns, Dobromir Dobrev, Anke C. Fender Tags: Editorial Source Type: research

GLP1RA versus SGLT2i tended to have more favorable ischemic outcomes including stroke?
In Kim and colleagues' article [1] reporting a retrospective cohort study aiming to assess the cardiorenal benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) versus glucagon-like peptide-1 receptor agonists (GLP1RA) in patients with type 2 diabetes mellitus (T2DM), one main conclusion is that GLP1RA tended to have more favorable ischemic outcomes. To some extent, this conclusion is exaggerated because GLP1RA and SGLT2i had the similar risks of coronary revascularization and stroke according to the main results of this article.
Source: International Journal of Cardiology - July 12, 2022 Category: Cardiology Authors: Lixin Du, Yu Zhang, Pan Wang, Zhigang Li, Yunhui Zhao, Jianpeng Yuan Tags: Letter to the Editor Source Type: research

Clinical outcomes of left atrial appendage occlusion versus direct oral anticoagulation in patients with atrial fibrillation and prior ischemic stroke: A propensity-score matched study
This propensity-score matched study investigated clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulation (DOAC) in patients with AF and prior ischemic stroke.
Source: International Journal of Cardiology - June 30, 2022 Category: Cardiology Authors: Kasper Korsholm, Jan B. Valentin, Dorte Damgaard, Hans-Christoph Diener, Alan John Camm, Ulf Landmesser, David Hildick-Smith, S øren Paaske Johnsen, Jens Erik Nielsen-Kudsk Source Type: research

Stroke in ATTR cardiac amyloidosis: does rhythm only matter?
Transthyretin amyloidosis (ATTR) is frequently associated with cardiac involvement in the wild type form (wtATTR) as well as in the mutated form (variant ATTR, vATTR). Although left ventricular (LV) pseudohypertrophy is currently considered a most relevant structural abnormality in cardiac amyloidosis (CA), atrial involvement due to both amyloid infiltration and secondary to LV overload and remodeling, is another key feature and a major determinant of decompensation, especially when associated with atrial arrhythmias [1].
Source: International Journal of Cardiology - June 15, 2022 Category: Cardiology Authors: Giuseppe Vergaro, Alberto Aimo, Vincenzo Castiglione, Michele Emdin Tags: Editorial Source Type: research

Implementation of a CT-derived correction factor to refine the measurement of aortic valve area and stroke volume using Doppler echocardiography improves grading of severity and prediction of prognosis in patients with severe aortic stenosis
Aims: To assess rates of reclassification of severity and associated 5-year survival in patients with severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF) after application of a CT-derived correction factor (CF) to refine the measurement of aortic valve area (AVA) and stroke volume index (SVi) using Doppler echocardiography.Methods and Results: We enrolled 1450 patients with severe AS and preserved LVEF from a French registry. Multiplication of echocardiographic LV outflow tract diameter by a CT-derived CF of 1.13 to calculate the AVA and SVi using the continuity equation resulted in reclassi...
Source: International Journal of Cardiology - June 15, 2022 Category: Cardiology Authors: Attila Kardos, Dan Rusinaru, Sylvestre Mar échaux, Ebraham Alskaf, Bernard Prendergast, Christophe Tribouilloy Source Type: research

Stroke in ATTR cardiac amyloidosis: Does only rhythm matter?
Transthyretin amyloidosis (ATTR) is frequently associated with cardiac involvement in the wild type form (wtATTR) as well as in the mutated form (variant ATTR, vATTR). Although left ventricular (LV) pseudohypertrophy is currently considered the most relevant structural abnormality in cardiac amyloidosis (CA), atrial involvement due to both amyloid infiltration and secondary to LV overload and remodeling, is another key feature and a major determinant of decompensation, especially when associated with atrial arrhythmias [1].
Source: International Journal of Cardiology - June 15, 2022 Category: Cardiology Authors: Giuseppe Vergaro, Alberto Aimo, Vincenzo Castiglione, Michele Emdin Tags: Editorial Source Type: research

Differential cardiovascular and renal benefits of SGLT2 inhibitors and GLP1 receptor agonists in patients with type 2 diabetes mellitus
Background:The differential benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) in cardiovascular or renal outcomes have not been fully investigated.Methods: Patients with diabetes prescribed SGLT2i or GLP1RA were retrospectively identified. Patients treated with antihyperglycemic medications other than SGLT2i or GLP1RA were used as a control group. Primary outcomes were composite ischemic events (acute coronary syndrome, coronary revascularization, and stroke) and a composite of heart failure and renal events (hospitalization for heart failure, renal death,...
Source: International Journal of Cardiology - June 14, 2022 Category: Cardiology Authors: Chee Hae Kim, In-Chang Hwang, Hong-Mi Choi, Chang Ho Ahn, Yeonyee E. Yoon, Goo-Yeong Cho Source Type: research

Assessment of atrial function by echocardiography: Can this be used to assess the arrhythmogenic atrial substrate?
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. It is associated with a high risk for thromboembolic stroke, heart failure, decreased quality of life and cognitive impairment, all increasing mortality. After confirmation of AF, comprehensive assessment of i) stroke risk, ii) symptom severity, iii) severity of AF-burden and iv) atrial substrate severity is recommended in accordance with the 4S-AF scheme proposed by the current European AF-guidelines to provide optimal treatment for the individual patient [1].
Source: International Journal of Cardiology - June 1, 2022 Category: Cardiology Authors: Florian Bruns, Dobromir Dobrev Tags: Editorial Source Type: research

The great discovery of DOACs and why physicians insist on misusing it: A paradox of the 21 century
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and has been one of the most studied disease in the world for the last 20  years. As it is a frequent cause of preventable strokes, substantial research efforts were directed toward gaining detailed information about effective prophylactic treatments. New evidence has been continuously published and resulted in the approval of direct-acting oral anticoagulants (DOACs) i n this scenario, which are safer and easier to use than vitamin K antagonists (VKA).[1]Although the randomized clinical trials that substantiated the approval of DOACs were based in ...
Source: International Journal of Cardiology - June 1, 2022 Category: Cardiology Authors: Fl ávia Bittar B. Arantes, Remo H.M. Furtado Tags: Editorial Source Type: research

Predicting LV thrombosis after acute myocardial infarction: From Virchow's triad to state-of-the-art cardiovascular magnetic resonance imaging
Despite the decline in incidence - in the era of primary percutaneous interventions (PCI), left ventricular (LV) thrombus remains a feared complication after acute myocardial infarction (AMI) due to the associated high risk of systemic embolism and stroke [1,2]. Depending on infarct/reperfusion-related characteristics as well as type and timing of diagnostic imaging modality, reported rates of LV thrombus following AMI are widely variable: from 2.7% for all and 9.1% for anterior ST-elevation myocardial infarction (STEMI), within 3  months on echocardiography, to 6.3% for all /19.2% for anterior STEMI with LV ejection fraction (LVEF) 
Source: International Journal of Cardiology - May 18, 2022 Category: Cardiology Authors: Anca Florian Tags: Editorial Source Type: research

Predictive value of left atrial strain in relation to atrial fibrillation following acute myocardial infarction
This study aimed to determine the prognostic value of left atrial (LA) strain, obtained by speckle tracking echocardiography (STE), in predicting incident AF outcomes following STEMI treated with primary percutaneous coronary intervention (pPCI).Methods and results:This prospective study comprised of 392 STEMI patients treated with pPCI.
Source: International Journal of Cardiology - May 13, 2022 Category: Cardiology Authors: Anne-Sophie Winther Svartstein, Mats H øjbjerg Lassen, Kristoffer Grundtvig Skaarup, Gabriela Lladó Grove, Frederikke Vyff, Kirstine Ravnkilde, Sune Pedersen, Søren Galatius, Daniel Modin, Tor Biering-Sørensen Source Type: research