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Source: Thrombosis and Haemostasis
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Total 528 results found since Jan 2013.
Oral Anticoagulation Timing in Patients with Acute Ischaemic Stroke and Atrial Fibrillation
CONCLUSIONS: In AF patients with severe AIS, early OAC use before the guideline-recommended days appeared to increase the risk of bleeding events, although the OAC initiation time seemed not to affect the risk of serious vascular events. The optimal severity-specific timing for OAC initiation after AIS requires further evaluation.PMID:34649296 | DOI:10.1055/a-1669-4987
Source: Thrombosis and Haemostasis - October 14, 2021 Category: Hematology Authors: Po-Yin Chang Weiting Wang Wei-Lun Wu Hui-Chin Chang Chen-Huan Chen Yi-Wen Tsai Shih-Hwa Chiou Gregory Yh Lip Hao-Min Cheng Chern-En Chiang Source Type: research
Reduced-dose intravenous thrombolysis for acute intermediate high-risk pulmonary embolism: Rationale and design of the PEITHO-3 trial
Thromb Haemost. 2021 Sep 24. doi: 10.1055/a-1653-4699. Online ahead of print.ABSTRACTIntermediate high-risk pulmonary embolism (PE) is characterised by right ventricular (RV) dysfunction and elevated circulating cardiac troponin levels despite apparent haemodynamic stability at presentation. In these patients, full-dose systemic thrombolysis reduced the risk of haemodynamic decompensation or death but increased the risk of life-threatening bleeding. Reduced-dose thrombolysis may be capable of improving safety while maintaining reperfusion efficacy. The Pulmonary Embolism International Trial (PEITHO)-3 study (EudraCT 2018-0...
Source: Thrombosis and Haemostasis - September 24, 2021 Category: Hematology Authors: Olivier Sanchez Anais Charles-Nelson Walter Ageno Stefano Barco Harald Binder Gilles Chatellier Daniel Duerschmied Klaus Empen Melanie Ferreira Philippe Girard Menno V Huisman David Jim énez Sandrine Katsahian Matija Kozak Mareike Lankeit Nicolas Menevea Source Type: research
Why Fibrin Biomechanical Properties Matter for Haemostasis and Thrombosis
J Thromb Haemost. 2021 Sep 16. doi: 10.1111/jth.15531. Online ahead of print.ABSTRACTPolymeric fibrin displays unique structural and biomechanical properties that contribute to its essential role of generating blood clots that stem bleeds. The aim of this review is to discuss how the fibrin clot is formed, how protofibrils make up individual fibrin fibres, what the relationship is between the molecular structure and fibrin biomechanical properties, and how fibrin biomechanical properties relate to the risk of thromboembolic disease. Fibrin polymerisation is driven by different types of bonds, including knob-hole interactio...
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: T ímea Feller Simon D A Connell Robert A S Ari ёns Source Type: research
Extended-Duration Low-intensity Apixaban to Prevent Recurrence in Patients with Provoked Venous Thromboembolism: Design of the HI-PRO Trial
Thromb Haemost. 2021 Sep 16. doi: 10.1055/a-1646-2244. Online ahead of print.ABSTRACTPatients with acute venous thromboembolism (VTE) in the setting of transient provoking factors are typically treated with short-term anticoagulation. However, the risk of recurrence may be increased in the presence of enduring risk factors. In such patients, the optimal duration of treatment remains uncertain. HI-PRO is a single-center, double-blind randomized trial. Patients with deep vein thrombosis (DVT) or pulmonary embolism (PE) following a major provoking factor, including major surgery or major trauma, who completed at least 3 month...
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: Behnood Bikdeli Heather Hogan Ruth Morrison John Fanikos Umberto Campia Briana Barns Mariana Pfeferman Julia Snyder Candrika Khairani Samuel Z Goldhaber Gregory Piazza Source Type: research
Integrated Care for Stroke Management: Easy as ABC
Thromb Haemost. 2021 Sep 2. doi: 10.1055/a-1632-1777. Online ahead of print.ABSTRACTNo Abstract.PMID:34474499 | DOI:10.1055/a-1632-1777
Source: Thrombosis and Haemostasis - September 2, 2021 Category: Hematology Authors: Gregory Yh Lip George Ntaios Source Type: research
Screening for Atrial Fibrillation in Relation to Stroke and Mortality Risk
Thromb Haemost. 2021 Aug 24. doi: 10.1055/s-0041-1735189. Online ahead of print.NO ABSTRACTPMID:34428835 | DOI:10.1055/s-0041-1735189
Source: Thrombosis and Haemostasis - August 24, 2021 Category: Hematology Authors: Marco Proietti Giuseppe Boriani Source Type: research
KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression
In conclusion, KLF11 protects against venous thrombosis, constituting a potential molecular target for treating thrombosis.PMID:34428834 | DOI:10.1055/s-0041-1735191
Source: Thrombosis and Haemostasis - August 24, 2021 Category: Hematology Authors: Wenying Liang Haocheng Lu Jinjian Sun Guizhen Zhao Huilun Wang Yanhong Guo Daniel Eitzman Y Eugene Chen Yanbo Fan Jifeng Zhang Source Type: research
Anticoagulation use and the risk of stroke and major bleeding in patients on hemodialysis: From the VIVALDI, a population-based prospective cohort study
CONCLUSIONS: Although the non-randomized nature of the study is prone to bias, anticoagulation with VKA was not associated with decreased thromboembolic risk, but associated with increased risk of major bleeding and may be net-harmful to patients with AF on HD.PMID:34418291 | DOI:10.1111/jth.15508
Source: Thrombosis and Haemostasis - August 21, 2021 Category: Hematology Authors: Oliver K önigsbrügge Hannah Meisel Aljoscha Beyer Sabine Schmaldienst Renate Klauser-Braun Matthias Lorenz Martin Auinger Josef Kletzmayr Manfred Hecking Wolfgang C Winkelmayer Irene Lang Ingrid Pabinger Marcus S äemann Cihan Ay Source Type: research
Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension
CONCLUSIONS: Our study explains the activation of mechanoreceptor Piezo1 under hypertension is the key to abnormal platelet activation and thrombosis while providing novel platelet intervention strategies to prevent thrombosis.PMID:34411418 | DOI:10.1111/jth.15504
Source: Thrombosis and Haemostasis - August 19, 2021 Category: Hematology Authors: Weiyu Zhao Zeliang Wei Guang Xin Yulong Li Jiyan Yuan Yue Ming Chengjie Ji Qiushi Sun Shiyi Li Xinchuan Chen Wei Fu Ye Zhu Hai Niu Wen Huang Source Type: research
Oral anticoagulant use in patients with morbid obesity: A systematic review and meta-analysis
CONCLUSIONS: Patients with morbid obesity on DOACs had similar risks of stroke/systemic embolism, lower rates of recurrent VTE and major bleeding events compared to those on VKAs. However, the certainty of evidence was low given that studies were mostly observational with high risk of confounding.PMID:34399433 | DOI:10.1055/a-1588-9155
Source: Thrombosis and Haemostasis - August 16, 2021 Category: Hematology Authors: Tzu-Fei Wang Marc Carrier Karine Fournier Deborah M Siegal Gr égoire Le Gal Aur élien Delluc Source Type: research
