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Source: Journal of Neurology
Condition: Ischemic Stroke

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Total 227 results found since Jan 2013.

MR-imaging pattern is not a predictor of occult atrial fibrillation in patients with cryptogenic stroke
ConclusionsIn this MRI-based analysis of patients with cryptogenic stroke who had received ICM implantation, the detection rate of AF in patients with ICM was not related to the imaging pattern. In addition, the lacunar infarct pattern should not be an exclusion criterion for ICM insertion in patients with cryptogenic stroke. ICM insertion in patients with cryptogenic stroke should not be evaluated solely on the basis of reference to infarct patterns.
Source: Journal of Neurology - September 10, 2019 Category: Neurology Source Type: research

Cumulative alcohol consumption and stroke risk in men
ConclusionsCumulative alcohol consumption is an independent risk factor of total stroke and IS in men in a community-based cohort. Even light alcohol intake increases the risk of total stroke and IS.
Source: Journal of Neurology - August 8, 2019 Category: Neurology Source Type: research

Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction
ConclusionsThe results from this study inform on sNfL in ischemic stroke and subtypes over time, and show that sNfL predicts short- and long-term neurological and functional outcomes. Our findings suggest a potential utility of sNfL in ischemic stroke outcome prediction.
Source: Journal of Neurology - August 1, 2019 Category: Neurology Source Type: research

Idarucizumab administration in emergency situations: the Munich Registry of Reversal of Pradaxa ® in clinical routine (MR REPAIR)
ConclusionIn our study, we have shown that the administration of Idarucizumab is a rare intervention and restricted to patients with severe bleeding complications or ischemic stroke. The clinical outcome of patients who received Idarucizumab in emergency situations was poor.
Source: Journal of Neurology - August 1, 2019 Category: Neurology Source Type: research

Misjudgment of pre-stroke functional status contradicts beneficial outcomes after endovascular therapy for large vessel occlusion
In conclusion, thorough pre-EVT assessment of pre-stroke functional status appears decisive for proper selection of EVT candidates.
Source: Journal of Neurology - July 18, 2019 Category: Neurology Source Type: research

Selection of anterior circulation acute stroke patients for mechanical thrombectomy
ConclusionsTVSS is a reliable tool for selection of AIS candidates for MT and optimization of transfer to comprehensive stroke centers.
Source: Journal of Neurology - July 2, 2019 Category: Neurology Source Type: research

Thrombocytopenia and declines in platelet counts: predictors of mortality and outcome after mechanical thrombectomy
ConclusionIn AIS patients treated with MT an initial TP was independently associated with higher mortality rates and a marked DPC with higher mortality rates as well as poorer clinical outcomes.
Source: Journal of Neurology - June 20, 2019 Category: Neurology Source Type: research

Intra-arterial thrombectomy for acute ischaemic stroke patients with active cancer
ConclusionsAlthough baseline characteristics and recanalisation rate after IAT up to 24  h after stroke onset were similar between acute ischaemic stroke patients with active cancer and without any cancer, stroke-related death and short-term outcome were significantly poorer in patients with active cancer than the controls. Post-procedural haemorrhage and active cancer itself were ind ependent predictors of a decrease in functional independence at 3 months.
Source: Journal of Neurology - June 6, 2019 Category: Neurology Source Type: research

Stroke severity in patients with preceding direct oral anticoagulant therapy as compared to vitamin K antagonists
AbstractBackgroundAlthough direct oral anticoagulants (DOAC) have proven at least equally effective in the prevention of acute ischemic stroke (AIS) in patients with atrial fibrillation as compared to the vitamin K antagonists (VKA), no reliable data on the severity of AIS of DOAC patients as compared to VKA is available.MethodsUsing a prospectively collected cohort of AIS patients, we performed univariate and multivariate (displayed as adjusted Odds Ratios, OR and 95% confidence intervals, 95% CI) analyses regarding the severity of AIS in patients with preceding DOAC (N = 210) versus VKA (N = 173) therapy. Additio...
Source: Journal of Neurology - June 3, 2019 Category: Neurology Source Type: research

Risk factors for in-hospital and follow-up mortality after childhood arterial ischemic stroke
ConclusionsThis study identified groups with greater acute and long-term  mortality after a first episode of AIS in childhood. Specific interventions focused on these risk groups may decrease mortality rates. Further studies need to confirm our findings by adding children from other centers.
Source: Journal of Neurology - May 14, 2019 Category: Neurology Source Type: research

Specific mechanisms of subarachnoid hemorrhage accompanied by ischemic stroke in essential thrombocythemia: two case reports and a literature review
ConclusionsThe current study describes rare cases of SAH accompanied by ischemic stroke secondary to ET along with a review of the current literature, implying specific mechanisms for cerebral artery disorders associated withJAK2 V617F mutation.
Source: Journal of Neurology - May 1, 2019 Category: Neurology Source Type: research

Clinical presentation of Moyamoya angiopathy in Europeans: experiences from Germany with 200 patients
ConclusionsCompared with Asian data, cerebral hemorrhages are infrequent and female predominance is accentuated among European Caucasians. Some former unknown rare features like associated livedo racemosa, dysgenesis of corpus callosum and associated syncope have been discovered systematically for the first time in this huge European Caucasian cohort.
Source: Journal of Neurology - March 12, 2019 Category: Neurology Source Type: research

Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or  TIA
AbstractPost-stroke dementia is common but has heterogenous mechanisms that are not fully understood, particularly in patients with atrial fibrillation (AF)-related ischaemic stroke or TIA. We investigated the relationship between MRI small-vessel disease markers (including a composite cerebral amyloid angiopathy, CAA, score) and cognitive trajectory over 12  months. We included patients from the CROMIS-2 AF study without pre-existing cognitive impairment and with Montreal Cognitive Assessment (MoCA) data. Cognitive impairment was defined as MoCA<  26. We defined “reverters” as patients with an “acute” MoCA (...
Source: Journal of Neurology - March 6, 2019 Category: Neurology Source Type: research

Cerebral microbleeds are associated with cognitive decline early after ischemic stroke
ConclusionCognitive abilities are more severely impaired in CMB-positive stroke patients compared to CMB-free controls, whereby memory-associated functions are most affected. CMB might be associated with post-stroke cognitive decline, particularly with impaired memory and phonemic fluency.
Source: Journal of Neurology - February 14, 2019 Category: Neurology Source Type: research

Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke
ConclusionsEarly CBF response to mild HOB elevation in the ipsilesional hemisphere is related to functional outcome. Further studies may enable optical monitoring at the bedside to individualize management strategies in the early phase of AIS.
Source: Journal of Neurology - February 9, 2019 Category: Neurology Source Type: research