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Source: Journal of Neurology
Condition: Ischemic Stroke

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Total 227 results found since Jan 2013.

The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study
ConclusionBoth early-onset and late-onset seizures do not influence long-term mortality after ischemic stroke.
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

Patent foramen ovale and stroke
AbstractA patent foramen ovale (PFO) is a highly prevalent finding in cryptogenic ischaemic stroke, particularly in young adults. A common challenge in clinical practice is to distinguish between incidental and pathogenic PFO. Some clinical features and tools such as the Risk of Paradoxical Embolism score may help determining the probability of a stroke-related PFO. Nonetheless, the best therapeutic option to reduce stroke recurrence after a cryptogenic stroke with PFO has been a matter of debate for a long time. We review the mechanisms of stroke-related PFO, together with its clinical features and diagnostic criteria. In...
Source: Journal of Neurology - April 21, 2018 Category: Neurology Source Type: research

Impaired fasting glucose is associated with unfavorable outcome in ischemic stroke patients treated with intravenous alteplase
ConclusionsIFG is associated with unfavorable outcome after treatment with intravenous alteplase for acute ischemic stroke. IFG predicts unfavorable outcome better than hyperglycemia on admission.
Source: Journal of Neurology - April 17, 2018 Category: Neurology Source Type: research

A novel frameshift variant in the CADASIL gene NOTCH3 : pathogenic or not?
AbstractCerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) represents the most common monogenic cause of adult-onset ischemic stroke and vascular dementia. It is caused by heterozygous missense mutations in theNOTCH3 gene, encoding a transmembrane receptor protein on vascular smooth muscle cells. Classical CADASIL mutations affect conserved cysteine residues of the Notch3 protein. By contrast, the role of non-canonical genetic variation inNOTCH3, in particular of variants causing a hypomorphic Notch3 protein, is subject to an ongoing scientific debate. In this context, we h...
Source: Journal of Neurology - March 29, 2018 Category: Neurology Source Type: research

Influence of on-going treatment with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker on the outcome of patients treated with intravenous rt-PA for ischemic stroke
ConclusionIn patients treated by intravenous thrombolytic therapy for ischemic stroke, on-going treatment with ACE-Is or ARBs does not influence on outcomes after adjustment on baseline characteristics and propensity scores.
Source: Journal of Neurology - March 16, 2018 Category: Neurology Source Type: research

Primary ‘dehydration’ and acute stroke: a systematic research review
ConclusionsWe found considerable variation in terminology specific to hydration status, diagnostic approach to dehydration, and few prospective studies of treatment strategies with varying results. This review supports the need for consensus development of operational diagnostic criteria, standardization of language, and the opportunity for prospective study of rehydration strategies to impact outcome after stroke.
Source: Journal of Neurology - March 1, 2018 Category: Neurology Source Type: research

University education and cervical artery dissection
ConclusionWe observed a higher rate of university education in patients with CeAD compared with non-CeAD patients in our study population. University education was associated with favorable outcome in CeAD-patients. The mechanism behind this association remains unclear.
Source: Journal of Neurology - February 24, 2018 Category: Neurology Source Type: research

Increased platelet count and reticulated platelets in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic signal-negative patient subgroups: results from the HaEmostasis In carotid STenosis (HEIST) study
DiscussionThe combination of increased platelet counts and a shift towards production of an increased population of larger, young, reticulated platelets could contribute to a higher risk of first or recurrent cerebrovascular events in recently symptomatic versus asymptomatic carotid stenosis, including those who are MES −ve.
Source: Journal of Neurology - February 23, 2018 Category: Neurology Source Type: research

Association between marriage and outcomes in patients with acute ischemic stroke
ConclusionsMarital status was associated with all adverse stroke outcomes in patients with acute ischemic stroke, especially in those with middle-school education.
Source: Journal of Neurology - February 20, 2018 Category: Neurology Source Type: research

Predicting functional outcomes of posterior circulation acute ischemic stroke in first 36  h of stroke onset
In conclusion, both the PC-ASPECTS and NIHSS help clinicians predict functional outcomes. PC-ASPECTS >  7 is a helpful discriminator for achieving favorable functional outcome prediction in posterior circulation acute ischemic stroke.
Source: Journal of Neurology - February 17, 2018 Category: Neurology Source Type: research

A systematic review of economic evaluations on stent-retriever thrombectomy for acute ischemic stroke
ConclusionThis review shows that SRT added/not added to IV t-PA is likely to be cost-effective or even dominant, which is consistent with the opinion from several Health Technology Assessment bodies recommending SRT. However, our findings are supported by primary studies with substantial methodological heterogeneity.
Source: Journal of Neurology - February 1, 2018 Category: Neurology Source Type: research

Cerebrovascular events in Takayasu arteritis: a multicenter case-controlled study
ConclusionsStroke is a major cause of disability in TA patients. Internal carotid surgery may be performed with caution because of the risk of stroke after the procedure.
Source: Journal of Neurology - February 1, 2018 Category: Neurology Source Type: research

Closure of patent foramen ovale for cryptogenic stroke patients: an updated systematic review and meta-analysis of randomized trials
ConclusionsTDC plus anti-thrombotic drugs is superior than medical therapy alone for secondary prevention of stroke, especially for those with male gender and with substantial shunt size of foramen ovale. Though it may increase the risk of postoperative atrial fibrillation, it would not bring higher risk of all-cause mortality, total adverse events and bleeding.
Source: Journal of Neurology - January 30, 2018 Category: Neurology Source Type: research

Patent foramen ovale closure versus medical therapy in cases with cryptogenic stroke, meta-analysis of randomized controlled trials
ConclusionPFO closure results in a significant reduction in the recurrence of ischemic stroke compared to medical therapy alone, primarily antiplatelet, among cases with PFO and cryptogenic stroke.
Source: Journal of Neurology - January 22, 2018 Category: Neurology Source Type: research

ABCD3-I score and the risk of early or 3-month stroke recurrence in tissue- and time-based definitions of TIA and minor stroke
AbstractChanging definition of TIA from time to a tissue basis questions the validity of the well-established ABCD3-I risk score for recurrent ischemic cerebrovascular events. We analyzed patients with ischemic stroke with mild neurological symptoms arriving<  24 h after symptom onset in a phase where it is unclear, if the event turns out to be a TIA or minor stroke, in the prospective multi-center Austrian Stroke Unit Registry. Patients were retrospectively categorized according to a time-based (symptom duration below/above 24 h) and tissue-based (wi thout/with corresponding brain lesion on CT or MRI) definition of ...
Source: Journal of Neurology - January 11, 2018 Category: Neurology Source Type: research