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Source: Neurology

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Total 3153 results found since Jan 2013.

Role of atherosclerosis, clot extent, and penumbra volume in headache during ischemic stroke
Conclusions: Headache in the early phase of ischemic stroke tends to occur less often in patients with atherosclerosis than in patients without atherosclerosis in the large cerebral arteries. This finding lends support to the hypothesis that vessel wall elasticity is a necessary contributing factor in the occurrence of headache during acute ischemic stroke.
Source: Neurology - September 11, 2016 Category: Neurology Authors: van Os, H. J. A., Mulder, I. A., van der Schaaf, I. C., Kappelle, L. J., Velthuis, B. K., Broersen, A., Vos, J. A., Terwindt, G. M., Schonewille, W., Ferrari, M. D., Algra, A., van Walderveen, M. A. A., Wermer, M. J. H. Tags: All Headache, CT, All Clinical Neurology, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study
Conclusions: Higher levels of 4 biomarkers—CRP, tHcy, TNFR2, and VEGF—increased risk of IIS and improved the predictive ability of the Framingham Stroke Risk Profile score. Further research is warranted to explore their role as potential therapeutic targets.
Source: Neurology - September 18, 2016 Category: Neurology Authors: Shoamanesh, A., Preis, S. R., Beiser, A. S., Kase, C. S., Wolf, P. A., Vasan, R. S., Benjamin, E. J., Seshadri, S., Romero, J. R. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Cohort studies, Incidence studies, Infarction ARTICLE Source Type: research

Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke
Conclusions: Let7i is decreased in circulating leukocytes of patients with acute ischemic stroke. Mechanisms by which let7i regulates inflammatory response post stroke include targeting CD86, CXCL8, and HMGB1.
Source: Neurology - November 20, 2016 Category: Neurology Authors: Jickling, G. C., Ander, B. P., Shroff, N., Orantia, M., Stamova, B., Dykstra-Aiello, C., Hull, H., Zhan, X., Liu, D., Sharp, F. R. Tags: All Cerebrovascular disease/Stroke, Gene expression studies, Infarction ARTICLE Source Type: research

DCE-MRI blood-brain barrier assessment in acute ischemic stroke
Conclusion: BBB in acute stroke patients can be successfully assessed quantitatively. The decrease of BBB permeability in unaffected regions at follow-up may be an indicator of global BBB leakage even in vessel territories remote from the index infarct.
Source: Neurology - January 29, 2017 Category: Neurology Authors: Villringer, K., Sanz Cuesta, B. E., Ostwaldt, A.-C., Grittner, U., Brunecker, P., Khalil, A. A., Schindler, K., Eisenblätter, O., Audebert, H., Fiebach, J. B. Tags: Diagnostic test assessment, MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Association of multiple infarctions and ICAS with outcomes of minor stroke and TIA
Conclusions: The presence of multiple infarctions and ICAS were both associated with an increased risk of 90-day ischemic stroke in patients with minor stroke or TIA, while the presence of both imaging features had a combined effect. ClinicalTrials.gov identifier: NCT00979589.
Source: Neurology - March 12, 2017 Category: Neurology Authors: Pan, Y., Meng, X., Jing, J., Li, H., Zhao, X., Liu, L., Wang, D., Johnston, S. C., Wang, Y., Wang, Y., On behalf of the CHANCE Investigators Tags: All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control) ARTICLE Source Type: research

Target Stroke Implementation: Best Practice Strategies Cut Thrombolysis Time to < 30 minutes in a 1,550 Bed Academic Urban County Hospital (P4.280)
Conclusions:Individualized hospital gap analysis identifies targeted interventions to shorten treatment times. DTN and DTG time can be reduced with implementation of simple, low-cost interventions, with persistent effect and no increase in symptomatic intracranial hemorrhage or stroke mimic treatment.Disclosure: Dr. Marulanda-Londoño has nothing to disclose. Dr. Bhatt has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Asdaghi has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Akram has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. D’Amour has nothing to disclos...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Marulanda-Londono, E., Bhatt, N., Atchaneeyasakul, K., Asdaghi, N., Malik, A., Akram, N., Zhang, T., DAmour, D., Hesse, K., Sacco, R., Romano, J. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

High values of baseline and 24-hour Mean Arterial Pressure are associated with lower chance of early neurological improvement in acute stroke patients treated with thrombolysis (P4.286)
Conclusions:High baseline and 24-hr MAP values are associated with lower chance of achieving ENI after IV thrombolysis. Further studies are needed to better understand whether acute BP dysregulation can influence different clinical courses in the early phase of IV thrombolysis.Disclosure: Dr. Lorenzano has nothing to disclose. Dr. Caselli has nothing to disclose. Dr. Zingaro has nothing to disclose. Dr. Orlando has nothing to disclose. Dr. Toni has received research support from Bayer, Medtronic, and Boehriger Ingelheim.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lorenzano, S., Caselli, M. C., Zingaro, A., Orlando, F., Toni, D. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Can admission Brain Natriuretic Peptide level predict outcome after intravenous thrombolysis in acute ischemic stroke? (P4.287)
Conclusions:Elevated BNP level was not found to be an independent marker of poor outcome in acute ischemic stroke patients following intravenous thrombolysis.Disclosure: Dr. Gupta has nothing to disclose. Dr. Finlay has nothing to disclose. Dr. Jacob has nothing to disclose. Dr. Raina has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Hinduja has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Gupta, H., Finlay, C., Jacob, S., Raina, S., Lee, R., Hinduja, A. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Predictors of atrial fibrillation in patients with cryptogenic stroke (P6.294)
Conclusions:Consistent with prior studies, atrial fibrillation was found by outpatient monitoring in a notable percentage of cryptogenic stroke patients. Predictors of occult atrial fibrillation in our study population included PACs on EKG and higher TSH levels. Although an association between hyperthyroidism and atrial fibrillation has been well established, our results intriguingly suggest that hypothyroidism may be a predictive factor as well.Disclosure: Dr. Renati has nothing to disclose. Dr. Almeida has nothing to disclose. Dr. Warren has nothing to disclose. Dr. Wilson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Renati, S., Almeida, L., Warren, S., Wilson, C. Tags: Cardiovascular Issues in Ischemic Stroke Source Type: research

Effectiveness and Safety of Apixaban and Rivaroxaban Versus Warfarin for the Secondary Prevention of Stroke or Systemic Embolism Among Nonvalvular Atrial Fibrillation Patients (S51.001)
Conclusions:Among NVAF patients with a prior history of SSE, rivaroxaban reduced ischemic stroke and ICH risk versus warfarin and did not significantly impact major bleeding. Apixaban did not significantly alter patients’ risk of SSE or major bleeding compared to warfarin in this high-risk population.Study Supported by: Bayer Pharma AGDisclosure: Dr. Coleman has received personal compensation for activities with Janssen Scientific affairs, LLC, Bayer Pharma AG, and BIPI . Dr. Coleman has received research support from Janssen Scientific Affairs, LLC, and Bayer Pharma AG. Dr. Bunz has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Coleman, C., Bunz, T. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Age and the fuzzy edges of embolic stroke of undetermined source: Implications for trials
After an acute ischemic stroke, clinicians pursue further diagnostic assessment to identify the most plausible causes and tailor secondary prevention strategies. Available treatments with a high level of evidence for reducing recurrence stroke risk might include long-term oral anticoagulation in patients with a major-risk cardioembolic source (atrial fibrillation, prosthetic valves, etc), carotid endarterectomy in minor ischemic stroke related to moderate to severe internal carotid artery atherosclerotic stenosis, and best-practice medical management in those with lacunar stroke due to cerebral small vessel disease.1 Howev...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Charidimou, A. Tags: Stroke in young adults, All Clinical trials, All Cerebrovascular disease/Stroke, Embolism, Infarction EDITORIALS Source Type: research

Child Neurology: Childhood basilar artery occlusion and stroke
Stroke is one of the major causes of childhood mortality. Pediatric arterial ischemic stroke (PAIS) has an annual estimated rate as high as 3.3 cases per 100,000 children (with the vertebrobasilar territory involved in up to 36% of cases); however, the incidence of isolated childhood basilar artery occlusion (BAO) and stroke (BAS) is unknown.1 Adult BAO carries up to a 90% mortality rate, while death or severe neurologic deficits may be seen in 50% of children with BAO/BAS.1,2 The following case report describes a 12-year-old boy with BAO leading to BAS. Clinical symptoms, differential diagnoses, associated comorbidities, ...
Source: Neurology - August 14, 2017 Category: Neurology Authors: Lobbous, M., Williams, S., Rashid, S. Tags: Childhood stroke, Stroke in young adults, All Cerebrovascular disease/Stroke, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke RESIDENT AND FELLOW SECTION Source Type: research

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke
Conclusions: Higher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Zhong, C., Yang, J., Xu, T., Xu, T., Peng, Y., Wang, A., Wang, J., Peng, H., Li, Q., Ju, Z., Geng, D., Zhang, Y., He, J., For the CATIS Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

Determinants of Early Outcomes in Patients with Acute Ischemic Stroke and Proximal Artery Occlusion (S02.005)
CONCLUSIONS: In acute ischemic stroke patients thought LTB from IAT, IV tPA independently predicted favorable early post-stroke outcomes. These data reinforce the recommendation to provide early, rapid IV tPA to all eligible patients. Further studies are warranted to explore the lack of IAT effect seen in this study, which may be due to small sample size, residual confounding, or interaction between the IV tPA and IAT.Disclosure: Dr. Labuzetta has nothing to disclose. Dr. Yoo has received research support from Penumbra Inc. Dr. Ali has nothing to disclose. Dr. Fitzpatrick has nothing to disclose. Dr. Hirsch has nothing to ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Labuzetta, J., Yoo, A., Ali, S., Fitzpatrick, K., Hirsch, J., Schwamm, L., Rost, N. Tags: S02 Acute Stroke Therapy Source Type: research

Thrombolytic Utilization in Ischemic Stroke Is Significantly Higher in US Hospitals with Neurology Residency Program (S02.006)
CONCLUSIONS: Stroke care at NR hospitals is associated with an increased thrombolytic utilization rate. The increased tPA utilization at NR between 2002-2006 may be related to the rapid increase in Primary Stroke Centers across the country.Disclosure: Dr. Moradiya has nothing to disclose. Dr. Grant has nothing to disclose. Dr. Valsamis has nothing to disclose. Dr. Levine has received personal compensation in an editorical capacity for MEDLINK.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Moradiya, Y., Grant, J., Valsamis, H., Levine, S. Tags: S02 Acute Stroke Therapy Source Type: research