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Specialty: Neurology
Source: JAMA Neurology
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Total 364 results found since Jan 2013.
Recurrent Stroke With Rivaroxaban Compared With Aspirin
This secondary analysis of a randomized clinical trial investigates whether rivaroxaban is associated with a reduction in recurrent stroke among patients with embolic stroke of undetermined source who have an increased risk of atrial fibrillation.
Source: JAMA Neurology - April 8, 2019 Category: Neurology Source Type: research
Endovascular Thrombectomy as a Means to Improve Survival in Acute Ischemic Stroke
This meta-analysis examines 90-day mortality and 90-day intracranial hemorrhage reported in trials of endovascular thrombectomy vs medical therapy cited in the 2018 American Stroke Association/American Heart Association guidelines for acute ischemic stroke.
Source: JAMA Neurology - April 8, 2019 Category: Neurology Source Type: research
Variations in Modeling for Treating Acute Stroke —Reply
In Reply We thank Maas et al for commenting on our recent article. We would like to emphasize that this modeling is intended to be a framework for prehospital decision making, particularly for systemwide planning. Our approach comes from the reality that transport decision making must be made with system and geographic context and the realization that there can never be randomized clinical trials of drip and ship vs mothership in all regions globally. The main advantage of a modeling approach is that these context-specific factors can be considered, entered into a model, and varied appropriately to ensure that the models r...
Source: JAMA Neurology - March 25, 2019 Category: Neurology Source Type: research
Variations in Modeling for Treating All Patients With Stroke With Suspected Large Vessel Occlusion
To the Editor We read the article by Holodinsky et al, who reported the results of a modeling study to identify the optimal triage and transport strategy for patients suspected of having large-vessel occlusion, with interest.
Source: JAMA Neurology - March 25, 2019 Category: Neurology Source Type: research
Thrombolysis Works in Lacunar Infarct, Complicating Imaging Selection
A new, exploratory analysis of the Efficacy and Safety of MRI-Based Thrombolysis in Wake-up Stroke (WAKE-UP) trial by Barow and colleagues in this issue ofJAMA Neurology provides unique and compelling data suggesting that thrombolysis improves clinical outcomes after acute lacunar infarction. The European Union –commissioned, 500-patient, randomized, double-blind, placebo-controlled WAKE-UP trial of alteplase captured the magnetic resonance imaging (MRI) and magnetic resonance angiography of patients with acute ischemic stroke prior to thrombolysis. This allowed categorization of infarcts as lacunar vs n onlacunar, using...
Source: JAMA Neurology - March 25, 2019 Category: Neurology Source Type: research
Error in Discussion Section
This article was corrected online.
Source: JAMA Neurology - March 18, 2019 Category: Neurology Source Type: research
Antiplatelet Therapy vs Anticoagulation in Cervical Artery Dissection
This randomized clinical trial examines whether antiplatelent or anticoagulant therapy is more effective in preventing stroke in cervical dissection and the risk of recurrent stroke in a randomized clinical trial setting.
Source: JAMA Neurology - February 25, 2019 Category: Neurology Source Type: research
Errors in Multiple Sections
The Original Investigation, “Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial,” published online January 18, 2019, contained several errors. In the byline, an additional degree, MSc, was added after the name of Eric Jü ttler, MD. In the Results section, the phrase “enrolled in the trial between August 2011 and September 2016” has been edited to end with “September 2015”; enrollment ended in that month, although data collection continued for an additional year. In addition, the sentence “Cardiovascular an ...
Source: JAMA Neurology - February 25, 2019 Category: Neurology Source Type: research
Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke
This validation study describes the development of a prognostic model to predict swallowing recovery and guide the decision for enteral tube feeding in people with dysphagia after ischemic stroke.
Source: JAMA Neurology - February 11, 2019 Category: Neurology Source Type: research
ABCB1 Polymorphisms and Outcomes of Clopidogrel Treatment for Minor Stroke or Transient Ischemic Attack
This secondary analysis of the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) randomized clinical trial investigates the association ofABCB1 polymorphisms with efficacy of clopidogrel plus aspirin vs aspirin alone in patients with minor stroke or transient ischemic attack.
Source: JAMA Neurology - February 11, 2019 Category: Neurology Source Type: research
Thrombectomy in Transferred Patients in the Late Window
This secondary analysis of the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 trial evaluates whether the imaging-based selection criteria used in the trial would lead to comparable outcome rates and treatment benefits in transfer vs direct-admission patients with ischemic stroke.
Source: JAMA Neurology - February 7, 2019 Category: Neurology Source Type: research
Pioglitazone Therapy in Patients With Stroke and Prediabetes
This post hoc analysis of Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial assesses the association of pioglitazone vs placebo with recurrent stroke, myocardial infarction, and other cardiovascular events.
Source: JAMA Neurology - February 7, 2019 Category: Neurology Source Type: research
Potential New Horizons for the Prevention of Cerebrovascular Diseases and Dementia
In this issue ofJAMA Neurology, Spence et al discuss the effect of pioglitazone, an insulin-sensitizing agent that has been shown to reduce the risk of recurrent stroke and myocardial infarction in patients with insulin resistance, in patients with prediabetes. Prediabetes was defined according to the American Diabetes Association criteria, ie, a hemoglobin A1c level of 5.7% to 6.4% or a fasting plasma glucose level of 100 to 125 mg/dL. Data were taken from the Insulin Resistance Intervention after Stroke (IRIS) study, an international randomized clinical trial performed in patients with previous stroke or transient ischem...
Source: JAMA Neurology - February 7, 2019 Category: Neurology Source Type: research
Association of Thrombectomy With Stroke Outcomes Among Patient Subgroups
This secondary analysis of a randomized clinical trial determines the association of thrombectomy among patients by age, symptom severity, time to randomization, arterial occlusive lesion location, and imaging modality.
Source: JAMA Neurology - January 28, 2019 Category: Neurology Source Type: research
Association of Time From Stroke Onset to Groin Puncture With Quality of Reperfusion After Mechanical Thrombectomy
This meta-analysis of individual patient data from 7 randomized clinical trials analyzes the rate of reperfusion after endovascular thrombectomy started at different intervals after symptom onset in patients with acute ischemic stroke.
Source: JAMA Neurology - January 22, 2019 Category: Neurology Source Type: research
