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Specialty: Neurology
Source: JAMA Neurology
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Total 364 results found since Jan 2013.
Implications of the National Institutes of Health Stroke Scale Cookie Theft Picture —A Closer Look
This Viewpoint discusses the implications of use of the National Institutes of Health Stroke Scale Cookie Theft picture.
Source: JAMA Neurology - June 13, 2022 Category: Neurology Source Type: research
Effect of Gamification With Social Incentives on Daily Steps After Stroke
This randomized clinical trial assesses whether gamification with social incentives increases daily steps among adults with stroke.
Source: JAMA Neurology - March 28, 2022 Category: Neurology Source Type: research
Incidence and Natural History of Pediatric Large Vessel Occlusion Stroke
This cohort study investigates the incidence and natural history of pediatric large vessel occlusion stroke.
Source: JAMA Neurology - March 28, 2022 Category: Neurology Source Type: research
The Road Not Taken
This essay describes the author ’s experience with having a stroke.
Source: JAMA Neurology - March 28, 2022 Category: Neurology Source Type: research
Provocative Hyperventilation in a Patient With SMART
This case report describes a patient with stroke-like migraine attacks after radiation therapy with recurrent and transient neurological deficits in whom provocative hyperventilation during routine electroencephalography was key for the diagnosis of seizures.
Source: JAMA Neurology - March 21, 2022 Category: Neurology Source Type: research
Diagnostic Challenges and Uncertainties of Embolic Strokes of Undetermined Source in Young Adults
Nearly 10% to 15% of acute ischemic strokes occur in young adults, with the incidence steadily increasing over the past few decades. Approximately 20% to 40% of these young patients with stroke are classified as having embolic strokes of undetermined source (ESUS), as the underlying stroke etiology cannot be reliably identified despite recommended diagnostic workup. The young ESUS population is an understudied group, as only a few studies, limited by their small size and the lack of prospective follow-up, have assessed their characteristics and outcomes.
Source: JAMA Neurology - March 14, 2022 Category: Neurology Source Type: research
Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source
This cohort study evaluates rates of and factors associated with recurrent ischemic stroke and death as well as new-onset atrial fibrillation among younger adults.
Source: JAMA Neurology - March 14, 2022 Category: Neurology Source Type: research
Inducers and Cardiovascular Risk —Potential Role for Lowered Drug Exposure—Reply
In Reply We thank Van der Linden and colleagues for their interest in our article, which describes the long-term cardiovascular risk associated with continued use of enzyme-inducing antiseizure medications (eiASMs). With respect to our mediation analysis, we considered incident dyslipidemia as a binary mediator variable, as opposed to a continuous variable of low-density lipoprotein cholesterol or total cholesterol, given its direct clinical relevance as the threshold over which treatment is initiated. However, we agree that future efforts at exploring a dose-dependent mediation between absolute and relative increases in l...
Source: JAMA Neurology - March 7, 2022 Category: Neurology Source Type: research
Low-Density Lipoprotein Cholesterol Level After a Stroke
Randomized clinical trials (RCTs) of statins as the primary prevention for patients with a high serum low-density lipoprotein cholesterol (LDL-C) level and as the secondary prevention after an acute coronary event have shown that lowering serum LDL-C levels reduces the risks of myocardial infarction, stroke, and vascular death. These trials included stroke as a secondary end point but not as an entry criterion. The benefit of LDL-C lowering to reduce the risk of ischemic strokes in primary prevention trials and for patients with coronary heart disease is not necessarily seen among patients who have had a stroke. The Stroke...
Source: JAMA Neurology - February 21, 2022 Category: Neurology Source Type: research
Intensity of LDL Cholesterol Lowering and Secondary Stroke Prevention
This meta-analysis of randomized clinical trials evaluates the association of more intensive vs less intensive low-density lipoprotein cholesterol –lowering statin-based therapies with outcomes for patients with ischemic stroke.
Source: JAMA Neurology - February 21, 2022 Category: Neurology Source Type: research
Data Do Not Support Selection of Patients for Stroke Treatment Within the 16- to 24-Hour Interval
To the Editor The Diffusion-Weighted Imaging or Computerized Tomography Perfusion Assessment With Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention With Trevo (DAWN) trial demonstrated benefit of endovascular treatment (EVT) in select patients 6 to 24 hours after last known well (LKW) with clinical imaging mismatch. The Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE 3) trial demonstrated benefit of EVT in select patients 6 to 16 hours after LKW with target perfusion-imaging mismatch. In the article by Albers et al, the authors present indepe...
Source: JAMA Neurology - February 14, 2022 Category: Neurology Source Type: research
Data Do Not Support Selection of Patients for Stroke Treatment Within the 16- to 24-Hour Interval —Reply
In Reply We thank Powers for his comments regarding our article. He raises the question if the positive result for patients with target perfusion-imaging mismatch in the 12.8- to 24-hour tercile in the Analysis of Pooled Data From Randomized Studies of Thrombectomy More Than 6 Hours After Last Well Known (AURORA) study could solely be due to a benefit from 12.8 to 16 hours since last known well subgroup, with neutral or negative effects in the 16- to 24-hour time period. This was not the case. Data for patients in the 16- to 24-hour group with the target mismatch profile demonstrated an odds ratio of 3.82 (95% CI, 1.07-13....
Source: JAMA Neurology - February 14, 2022 Category: Neurology Source Type: research
Disentangling Workflow Paradigms and Treatment Decision-making in Acute Ischemic Stroke
To the Editor We congratulate Requena and colleagues on their randomized trial, in which they compared a direct-to-angiography suite (DTAS) paradigm with a conventional workflow paradigm, ie, cross-sectional imaging, followed by transport to the angiography suite for endovascular treatment (EVT) when appropriate. The authors found that a DTAS paradigm not only decreased in-hospital workflow times but also increased the odds of patients undergoing EVT, both of which may have contributed to the improved clinical outcomes in the DTAS group.
Source: JAMA Neurology - February 7, 2022 Category: Neurology Source Type: research
Disentangling Workflow Paradigms and Treatment Decision-Making in Acute Ischemic Stroke —Reply
In Reply We thank Ospel and Goyal for their interest in the Evaluation of Direct Transfer to Angiography Suite vs Computed Tomography Suite in Endovascular Treatment (ANGIOCAT) study and read with interest their letter in which they express some concerns in relation to the direct-to-angiography suite (DTAS) paradigm. In the ANGIOCAT study, patients adjudicated to the conventional imaging group, despite receiving computed tomography perfusion (CTP) in some cases, achieved one of the shortest workflow times reported ever (door-to-puncture time of 44 minutes). According to guidelines, CTP was never used to exclude patients fr...
Source: JAMA Neurology - February 7, 2022 Category: Neurology Source Type: research
Mobile Stroke Unit or Usual Care for Acute Ischemic Stroke Management
This systematic review and meta-analysis investigates whether mobile stroke unit use is associated with better functional outcomes in patients with acute ischemic stroke.
Source: JAMA Neurology - February 7, 2022 Category: Neurology Source Type: research
