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Specialty: Neurology
Source: JAMA Neurology
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Total 364 results found since Jan 2013.
Lesion Size and Perspective in Acute Ischemic Stroke
The computed tomographic (CT) or magnetic resonance imaging (MRI) findings of early cerebral ischemia are literally, and figuratively, shades of gray in decision making regarding the triage of patients with acute ischemic stroke for revascularization. The subtleties and areas of uncertainty on imaging of this dynamic process, where an arterial occlusion is mitigated by collateral perfusion in the brain, defy concrete rules or thresholds that are equally consequential across individual patients. Imaging criteria, whether more than one-third of the middle cerebral artery territory, Alberta Stroke Program Early CT (ASPECT) sc...
Source: JAMA Neurology - November 7, 2016 Category: Neurology Source Type: research
Endovascular Treatment for Patients With Stroke and Large Ischemic Cores and Mismatch Imaging Profiles
This case-control study compares the outcomes of patients following stroke with large baseline ischemic cores on computed tomographic perfusion undergoing endovascular therapy with the outcomes of matched controls who had medical care alone.
Source: JAMA Neurology - November 7, 2016 Category: Neurology Source Type: research
Risk of Pregnancy-Associated Stroke Across Age Groups
This population-based cohort study uses data from the New York State SPARCS database to examine the risk of stroke in women of childbearing age who are pregnant or post partum compared with the risk in those who are not pregnant.
Source: JAMA Neurology - October 24, 2016 Category: Neurology Source Type: research
Mechanical Thrombectomy for Stroke
The publication of 5 randomized trials in 2015 unequivocally established that mechanical thrombectomy is the new standard of care for patients with acute ischemic stroke and an occlusion of the proximal anterior circulation. Although those trials mark a huge advancement in the field of stroke, important questions regarding the implementation of mechanical thrombectomy in routine clinical care remain. One of the more important of these questions is what constitutes the definition of a proximal occlusion. In those trials, most of the patients had an occlusion of the distal internal carotid artery or of the first segment (M1)...
Source: JAMA Neurology - September 12, 2016 Category: Neurology Source Type: research
Endovascular Therapy for Acute Ischemic Stroke
This pooled cohort study evaluates the safety and effectiveness of endovascular therapy for occlusions of the M2 segment of the middle cerebral artery in patients with ischemic stroke.
Source: JAMA Neurology - September 12, 2016 Category: Neurology Source Type: research
Association Between Calcium Level and Hematoma Size and Expansion
Intracerebral hemorrhage (ICH) is a common and deadly type of stroke, with high rates of morbidity and mortality (40%-50% in most series). There are several well-described and validated risk factors and diseases that increase the risk of ICH, including race, hypertension, use of anticoagulants, amyloid angiopathy, renal insufficiency, thrombolytic therapy, and drug abuse. However, not all ICHs are associated with one of these risk factors. This suggests that there might be some other modifying factors involved.
Source: JAMA Neurology - September 6, 2016 Category: Neurology Source Type: research
Neurologists and the Diagnosis of Acute Stroke in the ED
This Viewpoint proposes that acute stroke can be managed in the emergency department without the expertise of a neurologist.
Source: JAMA Neurology - September 6, 2016 Category: Neurology Source Type: research
Factors Associated With Neurological Outcome After Childhood Stroke
To the Editor We thank Grelli et al for their study investigating the factors associated with neurological outcome following childhood stroke. The authors reported an association between hyperglycemia and poor neurological outcome in their cohort.
Source: JAMA Neurology - August 22, 2016 Category: Neurology Source Type: research
The Dark Matter of Cerebral Microbleeds
To the Editor I read with interest the article by Tsivgoulis et al inJAMA Neurology on cerebral microbleeds (CMBs) and the risk for symptomatic intracerebral hemorrhage (ICH) after intravenous thrombolysis for acute stroke, as well as the accompanying Editorial by Fisher. This work follows and extends previous meta-analyses on a thorny topic for acute stroke neurology, demonstrating again that the presence of any number of CMBs on pretreatment magnetic resonance imaging is associated with more than doubling the risk for postthrombolysis ICH. Of importance, the authors provided new evidence from group-level and individual p...
Source: JAMA Neurology - August 15, 2016 Category: Neurology Source Type: research
Association Between CV Risk Factors and Familial Alzheimer Disease
This cohort study investigates associations between coronary risk factors, stroke, and late-onset Alzheimer dementia in patients with familial disease.
Source: JAMA Neurology - August 15, 2016 Category: Neurology Source Type: research
Racial Differences in Utilization of Inpatient Procedures After Stroke
This study compares racial differences in the use of 6 common nondiagnostic inpatient procedures after stroke.
Source: JAMA Neurology - July 25, 2016 Category: Neurology Source Type: research
Recruiting Patients With Stroke Into Cell Therapy Trials
This review examines ethical issues surrounding the recruitment of patients with stroke into cell therapy studies.
Source: JAMA Neurology - July 18, 2016 Category: Neurology Source Type: research
Stent Retrievers for Treating Anterior Circulation Acute Ischemic Stroke
To the Editor Touma et al reported a comprehensive systematic review and meta-analysis of 5 randomized clinical trials evaluating the benefits and risks of stent retrievers in addition to recombinant tissue plasminogen activator (rtPA) for the treatment of acute ischemic stroke (AIS). The main conclusion of the study was that “the use of stent retrievers in conjunction with rtPA vs rtPA alone is associated with significant improvement of functional independence 90 days after AIS.” However, as pointed out by the authors, all studies included in their meta-analysis selected only patients with anterior circulation acute i...
Source: JAMA Neurology - July 5, 2016 Category: Neurology Source Type: research
