Errors in Multiple Sections

The Original Investigation, “Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial,” published online January 18, 2019, contained several errors. In the byline, an additional degree, MSc, was added after the name of Eric Jü ttler, MD. In the Results section, the phrase “enrolled in the trial between August 2011 and September 2016” has been edited to end with “September 2015”; enrollment ended in that month, although data collection continued for an additional year. In addition, the sentence “Cardiovascular an d nervous system SAEs are listed in the eTable in Supplement 1” was deleted because the accompanying eTable is not presented in the Supplement, and the phrase “control group, 9 of 25 patients [83%]” in the Results subsection called “Early Mortality and Secondary Clinical End Points” was co rrected to “19 of 23 patients [83%].” Finally, erroneous hazard ratio (HR) values 1.40 and 2.60 in the sentence “Patients in the hypothermia group had a significantly higher risk for requiring mechanical ventilation than those in the control group (…HR, 1.40 [95% CI, 1.12-1.78];P = .003) and a significantly higher risk of receiving osmotherapy (…HR, 2.60 [95% CI, 1.43-4.58];P = .001)” were corrected to 1.42 and 2.56, respectively. In Table 1, the ...
Source: JAMA Neurology - Category: Neurology Source Type: research

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Authors: Ko WC, Lin CH, Lee JJ, Chang CP, Chao CM Abstract We aimed to ascertain whether therapeutic hypothermia (TH) acts as cardioprotective management for heat stroke (HS). Adult male rats under general anesthesia were exposed to whole-body heating (43°C for 70 min) to induce HS. Rats with HS displayed hyperthermia (core body temperature 42°C vs. 36°C); hypotension (30 mmHg vs. 90 mmHg mean arterial blood pressure); suppressed left ventricular (LV) performance (stroke volume 52 μl/min vs. 125 μl/min), ejection fraction (0.29% vs. 0.69%), relaxation factor (72 ms vs. 12 ms), and arterial elastan...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
In this study, researchers analyzed temperature recordings from three periods of time over 157 years: 1860–1940: A mix of armpit and oral temperatures of nearly 24,000 veterans of the Civil War were measured. 1971–1975: Oral temperatures of more than 15,000 people from a large population study (the National Health and Nutrition Examination Survey) were analyzed. 2007–2017: Oral temperatures of more than 150,000 people in another large research project (the Stanford Translational Research Integrated Database Environment) were reviewed. During the nearly 160 years covered by the analysis, the average oral...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Cold and Flu Men's Health Women's Health Source Type: blogs
CONCLUSION: Through combining anatomical, metabolic imaging and behavioral studies, our study provides evidence of neuroprotective effects of HT in NAIS. These results are potentially translational to human NAIS. PMID: 32115740 [PubMed - as supplied by publisher]
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Tags: Int J Dev Neurosci Source Type: research
Publication date: Available online 20 February 2020Source: Life SciencesAuthor(s): Mahsa Hassanipour, Mohammadreza Zarisfi, Vahid Ehsani, Mohammad AllahtavakoliAbstractLate treatment with tissue plasminogen activator (tPA) leads to reperfusion injury and poor outcome in ischemic stroke. We have recently shown the beneficial effects of local brain hypothermia after late thrombolysis. Herein, we investigated whether transient whole-body hypothermia was neuroprotective and could prevent the side effects of late tPA therapy at 5.5 h after embolic stroke. After induction of stroke, male rats were randomly assigned into four g...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsFor patients without aortic dissection and who require more than 30 minutes of circulatory arrest, optimal cerebral protection strategies are deep hypothermia with either antegrade or retrograde cerebral perfusion and moderate hypothermia with antegrade cerebral perfusion.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In conclusion, isoflurane protected against BBB disruption caused by carbogen inhalation in mice and rats, but unlike isoflurane-mediated protection against ischemic BBB disruption, the effect could not be explained by anesthesia-induced hypothermia.
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
CONCLUSIONS: Highly arbourised neurons are more sensitive to ischaemic injury than NPs which did however develop marked vulnerability to prolonged injury with reoxygenation. These observations imply that therapeutic potential may be highly dependent of the developmental state of the neurons we aim to protect. PMID: 31837459 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
This study proposes a multi-center RCT in order to compare outcomes of warmer hypothermic strategies during aortic hemiarch surgery on a composite endpoint of neurologic and acute kidney injury (AKI).Methods/designThis is a prospective multi-center, single-blind two-arm RCT comparing mild (32  °C) versus moderate (26 °C) hypothermic cardiac arrest in patients (n = 282) undergoing hemiarch surgery with antegrade cerebral perfusion (ACP). The primary endpoint is a composite of neurological injury (incidence of transient ischemic attack and/or stroke) and Kidney Disease Improving Global Out...
Source: Trials - Category: Research Source Type: clinical trials
This study aims to establish the initial safety of Triple Neuroprotection (TN) in surgical management of acute stroke.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
CONCLUSIONS: This meta-analysis suggests that after decades of extensive research, TH has yet to show a beneficial effect on mortality across different critical care diseases. PMID: 31778636 [PubMed - in process]
Source: Critical Care and Resuscitation - Category: Intensive Care Tags: Crit Care Resusc Source Type: research
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