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Source: The American Journal of Medicine
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Total 259 results found since Jan 2013.
A Review of Women's Neurology
Concern about what is best practice when caring for women with neurologic disease is a common clinical scenario. Therefore, knowledge about women's health issues and their intersection with neurologic disorders is imperative. This review will discuss the appropriate gender-based considerations in epilepsy, multiple sclerosis, migraine, autoimmune disease, sleep disorders, stroke, and paraneoplastic disorders.
Source: The American Journal of Medicine - December 27, 2017 Category: General Medicine Authors: Mary Angela O'Neal Tags: Review Source Type: research
Patent Foramen Ovale Closure for Secondary Prevention of Cryptogenic Stroke: Updated Meta-Analysis of Randomized Clinical Trials
• In patients with recent cryptogenic stroke, percutaneous closure of patent foramen ovale reduced recurrent stroke/transient ischemic attack compared with medical therapy, but was associated with higher risk of new-onset atrial fibrillation/flutter.• Select, young patients (≤60 years) present ing with recent cryptogenic stroke may benefit from percutaneous closure of patent foramen ovale at relatively low procedural risk.
Source: The American Journal of Medicine - December 8, 2017 Category: General Medicine Authors: Muthiah Vaduganathan, Arman Qamar, Ankur Gupta, Navkaranbir Bajaj, Harsh B. Golwala, Ambarish Pandey, Deepak L. Bhatt Tags: Brief Observation Source Type: research
Severity of Gastrointestinal Bleeding in Patients Treated with Direct-Acting Oral Anticoagulants
Direct-acting oral anticoagulants (DOACs), which have gained approval for stroke prevention in non-valvular atrial fibrillation and treatment of venous thromboembolism, have become increasingly preferred over warfarin given their predictable pharmacodynamics, lack of required monitoring, and superior outcomes. DOACs have been shown to be associated with an increased frequency of gastrointestinal bleeding compared to warfarin, but the severity and characteristics of gastrointestinal bleeding in these patients is poorly understood.
Source: The American Journal of Medicine - November 22, 2017 Category: General Medicine Authors: Mark M. Brodie, Jill C. Newman, Tyler Smith, Don C. Rockey Tags: Clinical Research Study Source Type: research
Falls and Delirium: Platypnea-Orthodeoxia Syndrome
An 85-year-old woman's inability to remain standing was ultimately connected to an undiagnosed congenital defect. The patient was admitted to the geriatric unit of a university hospital for new frequent falls and subacute delirium, both of which began a month before presentation. Her medical history included ischemic stroke 10 years earlier, mild neurocognitive impairment, and Von Recklinghausen neurofibromatosis with isolated skin involvement.
Source: The American Journal of Medicine - November 20, 2017 Category: General Medicine Authors: A. Putot, C. Laborde, M. Fichot, P. Brunel, M. Deidda, H. Guepet, P. Manckoundia Tags: Diagnostic Dilemma Source Type: research
Atrial Appendage Thrombosis Risk Is Lower for Atrial Flutter Compared with Atrial Fibrillation
The risk of stroke and thromboembolism in atrial fibrillation is established. However, the evidence surrounding the risk of thromboembolism in patients with atrial flutter is not as clear. We hypothesized that atrial flutter would have indicators of less risk for thromboembolism compared with atrial fibrillation on transesophageal echocardiography, thereby possibly leading to a lower stroke risk.
Source: The American Journal of Medicine - November 8, 2017 Category: General Medicine Authors: Jennifer J. Huang, Sridhar Reddy, Tam H. Truong, Prakash Suryanarayana, Joseph S. Alpert Tags: Clinical Research Study Source Type: research
Atrial Flutter Has Less Left Atrial Spontaneous Contrast and Higher Left Atrial Appendage Emptying Velocity Compared with Atrial Fibrillation
The risk of stroke and thromboembolism in atrial fibrillation is established. There are clear guidelines in anticoagulation management of patient's with atrial fibrillation, however, the evidence surrounding the risk of thromboembolism in patients with atrial flutter is not as clear. We hypothesized that atrial flutter would have indicators of less risk for thromboembolism compared with atrial fibrillation on transesophageal echocardiography (TEE); thereby possibly leading to a lower stroke risk.
Source: The American Journal of Medicine - November 8, 2017 Category: General Medicine Authors: Jennifer J. Huang, Sridhar Reddy, Tam H. Truong, Prakash Suryanarayana, Joseph S. Alpert Tags: Clinical Research Study Source Type: research
Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial
We assessed outcomes among anticoagulated patients with atrial fibrillation (AF) and a history of falling, and whether the benefits of apixaban versus warfarin are consistent in this population.
Source: The American Journal of Medicine - November 6, 2017 Category: General Medicine Authors: Meena P. Rao, Dragos Vinereanu, Daniel M. Wojdyla, John H. Alexander, Dan Atar, Elaine M. Hylek, Michael Hanna, Lars Wallentin, Renato D. Lopes, Bernard J. Gersh, Christopher B. Granger, on behalf of the Apixaban for Reduction in Stroke and Other Thromboe Tags: Clinical Research Study Source Type: research
Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population —A Prospective Population Study
Potassium supplementation reduces the risk of cardiovascular mortality and stroke in population studies; however, the prognostic impact of mild hypokalemia in the general population has not been thoroughly investigated. We aimed to investigate associations between mild hypokalemia and endpoints in the general population.
Source: The American Journal of Medicine - October 9, 2017 Category: General Medicine Authors: Nick Mattsson, Olav Wendelboe Nielsen, Linda Johnson, Eva Prescott, Peter Schnohr, Gorm Boje Jensen, Lars K øber, Ahmad Sajadieh Tags: Clinical Research Study Source Type: research
The Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population – a Prospective Population Study
• Potassium
Source: The American Journal of Medicine - October 9, 2017 Category: General Medicine Authors: Nick Mattsson, Olav Wendelboe Nielsen, Linda Johnson, Eva Prescott, Peter Schnohr, Gorm Boje Jensen, Lars K øber, Ahmad Sajadieh Tags: Clinical Research Study Source Type: research
Selective Reporting: Silent Atrial Fibrillation and Cryptogenic Strokes
I read with interest the article by Dalen and Alpert.1 Bothersome to me was the selectiveness of the data reported and the somewhat biased resultant interpretation. Consider: they did not mention the pivotal Cryptogenic Stroke and Underlying AF trial,2 in which the unmonitored control group had atrial fibrillation detected in 3% by 36 months, versus 3.7%, 8.9%, 12.4%, and 30.0% at 1, 6, 12, and 36 months, respectively, in the implanted monitor group. Notably, not only was the detection rate frequent with the implanted monitor but also greater than could have occurred with any external monitoring.
Source: The American Journal of Medicine - August 22, 2017 Category: General Medicine Authors: James A. Reiffel Tags: AJM online Source Type: research
Cerebral Air Embolism Following Central Venous Catheter Removal
Air embolism is a rare but potentially fatal complication of central venous catheterization1. Venous air emboli can paradoxically enter the arterial circulation through a patent foramen ovale. Paradoxical shunting of air emboli through a patent foramen ovale can lead to cerebral air embolism and cause neurological compromise2. An atrial septal aneurysm is redundant atrial tissue that protrudes towards either or both atria during the cardiac cycle. It significantly increases the risk of embolic stroke when associated with a patent foramen ovale3.
Source: The American Journal of Medicine - August 10, 2017 Category: General Medicine Authors: Liane A. Arcinas, Shuangbo Liu, G. Isanne Schacter, Malek Kass Tags: Clinical Communication to the Editor Source Type: research
Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights From the ARISTOTLE Trial
• Cancer and atrial fibrillation frequently coexist, yet there are few data to guide care in this population.• No significant associations between history of cancer and the risk of stroke/systemic embolism, major bleeding, or mortality were observed.• The safety and efficacy of apixaban versus warfarin appear to be preserved among patients with and without active cancer.
Source: The American Journal of Medicine - July 21, 2017 Category: General Medicine Authors: Chiara Melloni, Allison Dunning, Christopher B. Granger, Laine Thomas, Michel G. Khouri, David A. Garcia, Elaine M. Hylek, Michael Hanna, Lars Wallentin, Bernard J. Gersh, Pamela S. Douglas, John H. Alexander, Renato D. Lopes Tags: Clinical Research Study Source Type: research
Cardiovascular Protection in the Treatment of Type 2 Diabetes: A Review of Clinical Trial Results Across Drug Classes
Patients with type 2 diabetes (T2DM) have a significantly higher risk of developing cardiovascular disease (CVD) —namely myocardial infarction, heart failure, and stroke. Despite clear advances in the prevention and treatment of CVD, the impact of T2DM on CVD outcome remains high and continues to escalate. Available evidence indicates that the risk of macrovascular complications increases with the severity o f hyperglycemia, thus suggesting that the relation between metabolic disturbances and vascular damage is approximately linear.
Source: The American Journal of Medicine - May 26, 2017 Category: General Medicine Authors: Francesco Paneni, Thomas F. L üscher Tags: Clinical research study Source Type: research
