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Source: The American Journal of Medicine

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Total 259 results found since Jan 2013.

Thrombolysis; a critical first-line therapy with an unfulfilled potential
A blood clot or thrombus triggers the onset of most vascular diseases, like stroke or heart attack. Thrombolysis is the only treatment that can restore blood flow rapidly and easily. Unfortunately, the standard thrombolytic, tissue plasminogen activator (tPA), has proven inadequate and is being replaced by invasive endovascular procedures, which are time-consuming and limited in their availability in relation to the scope of the problem. Historically, when tPA clinical trials began, it was insufficiently recognized that without the other natural plasminogen activator, prourokinase (proUK), thrombolysis by tPA was seriously compromised.
Source: The American Journal of Medicine - December 20, 2015 Category: Journals (General) Authors: Victor Gurewich Tags: Review Source Type: research

Thrombolysis: A Critical First-Line Therapy with an Unfulfilled Potential
A blood clot or thrombus triggers the onset of most vascular diseases, like stroke or heart attack. Thrombolysis is the only treatment that can restore blood flow rapidly and easily. Unfortunately, the standard thrombolytic, tissue plasminogen activator (tPA), has proven inadequate and is being replaced by invasive endovascular procedures, which are time consuming and limited in their availability in relation to the scope of the problem. Historically, when tPA clinical trials began, it was not recognized sufficiently that without the other natural plasminogen activator, prourokinase (proUK), thrombolysis by tPA was seriously compromised.
Source: The American Journal of Medicine - December 20, 2015 Category: Journals (General) Authors: Victor Gurewich Tags: Review Source Type: research

Cardiovascular Benefits of the Mediterranean Diet Are Driven by Stroke Reduction and Possibly by Decreased Atrial Fibrillation Incidence
Widmer et al assemble a wealth of information on “The Mediterranean Diet, its Components, and Cardiovascular Disease,”1 a topic that is of ever-growing importance. They are right to call the Prevención con Dieta Mediterránea (PREDIMED) trial2 a “flagship study,” or, as I might paraphrase, a landmark study that changes clinical practice in terms of what diet we might recommend to our patients. PREDIMED was a well-designed randomized controlled trial with a significant sample size.
Source: The American Journal of Medicine - December 18, 2015 Category: Journals (General) Authors: Benjamin P. Geisler Tags: AJM online Source Type: research

Raised Intracranial Pressure Secondary to Vitamin Overdose
We report a patient for whom multi-vitamin ingestion was associated with neurological symptoms which mimicked acute stroke.
Source: The American Journal of Medicine - December 16, 2015 Category: Journals (General) Authors: Christopher Keith Oldroyd, Matthew Walters, Krishna Dani Tags: Clinical Communication to the Editor Source Type: research

Early Cardiovascular Disease After the Diagnosis of Systemic Sclerosis
To assess risk and time trends of newly recorded myocardial infarction and stroke in cases with systemic sclerosis.
Source: The American Journal of Medicine - November 18, 2015 Category: Journals (General) Authors: J. Antonio Aviña-Zubieta, Ada Man, Marko Yurkovich, Kun Huang, Eric C. Sayre, Hyon K. Choi Tags: Clinical Research Study Source Type: research

Can the reduction percentage LDL-C or Attained LDL-C levels or both add incremental prognostic value?
The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies.1,2,3,4 The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease.5
Source: The American Journal of Medicine - November 13, 2015 Category: Journals (General) Authors: Leonardo Roever Tags: Editorial Source Type: research

Can the Reduction in Percent LDL Cholesterol or Attained LDL Cholesterol Levels or Both Add Incremental Prognostic Value?
The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies.1-4 The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease.5
Source: The American Journal of Medicine - November 13, 2015 Category: Journals (General) Authors: Leonardo Roever Tags: Editorial Source Type: research

Evaluation of the HAS-BLED, ATRIA, and ORBIT Bleeding Risk Scores in Patients with Atrial Fibrillation Taking Warfarin
Various bleeding risk prediction schemes, such as the Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized Ratio, Elderly, Drugs/alcohol (HAS-BLED), Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA), and Outcomes Registry for Better Informed Treatment (ORBIT) scores, have been proposed in patients with atrial fibrillation. We compared the relative predictive values of these bleeding risk scores for clinically relevant bleeding and the relationship of ATRIA and ORBIT scores to the quality of anticoagulation control on warfarin, as reflected by...
Source: The American Journal of Medicine - October 16, 2015 Category: Journals (General) Authors: Keitaro Senoo, Marco Proietti, Deirdre A. Lane, Gregory Y.H. Lip Tags: Clinical research study Source Type: research

A cryptic case: isolated cerebral mucormycosis
A rare infection raging within the brain of a 50-year-old African-American man was impossible to diagnose until after his death. He presented to the emergency department after the acute onset of garbled speech, confusion, right-arm weakness, and right facial droop. His medical history was significant for poorly controlled diabetes mellitus and polysubstance abuse, including intravenous drug abuse. He had never had a stroke, had no sick contacts, and had not traveled recently.
Source: The American Journal of Medicine - October 5, 2015 Category: Journals (General) Authors: Monica B. Dhakar, Mahmoud Rayes, William Kupsky, Tselis Alexandros, Gregory Norris Tags: Diagnostic Dilemma Source Type: research

Improving medication adherence in patients with hypertension: a randomized trial
and Purpose: In patients with hypertension, medication adherence is often suboptimal, thereby increasing the risk of ischemic heart disease and stroke. In a randomized trial, we investigated the effectiveness of a multifaceted pharmacist intervention in a hospital setting to improve medication adherence in hypertensive patients. Motivational interviewing was a key element of the intervention.
Source: The American Journal of Medicine - August 21, 2015 Category: Journals (General) Authors: Ulla Hedegaard, Lene Juel Kjeldsen, Anton Pottegård, Jan Erik Henriksen, Jess Lambrectsen, Jørgen Hangaard, Jesper Hallas Tags: Clinical Research Study Source Type: research

Antithrombotic treatment patterns in 10 871 patients with newly diagnosed non-valvular atrial fibrillation: the GLORIA-AF Registry Program, Phase II
The Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) was designed to provide prospectively collected information on patients with newly diagnosed non-valvular atrial fibrillation at risk of stroke, with the aim of addressing treatment patterns and questions of effectiveness and safety.
Source: The American Journal of Medicine - July 31, 2015 Category: Journals (General) Authors: M.V. Huisman, K.J. Rothman, M. Paquette, C. Teutsch, H.C. Diener, S.J. Dubner, J.L. Halperin, Changsheng Marín, C.S. Ma, K. Zint, A. Elsaesser, D.B. Bartels, G.Y.H. Lip, GLORIA-AF Investigators Tags: Clinical Research Study Source Type: research

Antithrombotic Treatment Patterns in Patients with Newly Diagnosed Nonvalvular Atrial Fibrillation: The GLORIA-AF Registry, Phase II
The Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) was designed to provide prospectively collected information on patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke, with the aim of addressing treatment patterns and questions of effectiveness and safety.
Source: The American Journal of Medicine - July 31, 2015 Category: Journals (General) Authors: Menno V. Huisman, Kenneth J. Rothman, Miney Paquette, Christine Teutsch, Hans Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Changsheng Ma, Kristina Zint, Amelie Elsaesser, Dorothee B. Bartels, Gregory Y.H. Lip, GLORIA-AF Investigators Tags: Clinical research study Source Type: research

Antithrombotic Treatment Patterns in 10,871 Patients with Newly Diagnosed Nonvalvular Atrial Fibrillation: The GLORIA-AF Registry, Phase II
The Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) was designed to provide prospectively collected information on patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke, with the aim of addressing treatment patterns and questions of effectiveness and safety.
Source: The American Journal of Medicine - July 31, 2015 Category: Journals (General) Authors: Menno V. Huisman, Kenneth J. Rothman, Miney Paquette, Christine Teutsch, Hans Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Changsheng Ma, Kristina Zint, Amelie Elsaesser, Dorothee B. Bartels, Gregory Y.H. Lip, GLORIA-AF Investigators Tags: Clinical research study Source Type: research

Neither Abusiveness with Patients nor Naivety with Drugs
Kelly et al1 must be commended for condemning abusive language for individuals with addiction (eg, substance “abusers” or “addicts”) and recommending the use of “people with a substance use disorder.” Indeed, reducing stigma is vital for building the therapeutic alliance with these patients with low self-esteem. Sadly, this is not yet usual: Elkind,2 when discussing the risk of recurrent ischemic stroke, called smoking a “volitional behavior.” However, the condemnation of public health messages such as “war on drugs” or “You use, you lose” deserves comments.
Source: The American Journal of Medicine - June 17, 2015 Category: Journals (General) Authors: Alain Braillon Tags: AJM online Source Type: research

Summer Syncope Syndrome Redux
The objective of the present study was to investigate whether the results of our prior study involving continued use of antihypertensive drugs at the same dosage in the summer as in the winter months for patients living in the Sonoran desert resulted in an increase in syncopal episodes during the hot summer months.
Source: The American Journal of Medicine - June 4, 2015 Category: Journals (General) Authors: Jennifer Juxiang Huang, Chirag Desai, Nirmal Singh, Natasha Sharda, Irbaz Riaz, Joseph Alpert Tags: Brief Observation Source Type: research