Filtered By:
Source: The American Journal of Medicine

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 259 results found since Jan 2013.

High-Grade Carotid Artery Stenosis and Atrial Fibrillation
The disclosure of a higher rate of stroke among patients with the association of nonvalvular atrial fibrillation and peripheral vascular disease1 is entirely predictable given the fact that Kanter et al2 have shown that, among patients with nonvalvular atrial fibrillation, high-grade carotid artery stenosis (a risk factor for stroke)3 had a prevalence of 12% among men aged>70 years, and a prevalence of 11% among women of that age group. Furthermore, in their systematic review of 9 studies (2611 patients) reporting presumed pathophysiological stroke mechanisms in patients with atrial fibrillation, Katsi et al4 showed that 1...
Source: The American Journal of Medicine - December 1, 2020 Category: General Medicine Authors: Oscar M.P. Jolobe Tags: Letter Source Type: research

Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle
Vasculogenic erectile dysfunction has been aptly called the “canary in the coal mine” for cardiovascular disease because it almost always precedes other manifestations of atherosclerotic cardiovascular disease, including myocardial infarction and stroke. It is common, associated with the presence of modifiable cardiovascular risk factors, and impacted by diet and lifestyle choices. This concise review provides an update on the use of dietary and other lifestyle interventions to improve vasculogenic erectile dysfunction and atherosclerotic cardiovascular disease.
Source: The American Journal of Medicine - November 20, 2020 Category: General Medicine Authors: Robert J. Ostfeld, Kathleen E. Allen, Karen Aspry, Eric J. Brandt, Aaron Spitz, Joshua Liberman, Danielle Belardo, James H. O'Keefe, Monica Aggarwal, Michael Miller, Columbus Batiste, Stephen Kopecky, Beth White, Nikhil Shah, Hussam Hawamdeh, Travis Batts Tags: Review Source Type: research

Vasculogenic Erectile Dysfunction - The Impact of Diet and Lifestyle
Vasculogenic erectile dysfunction has been aptly called the “canary in the coal mine” for cardiovascular disease as it almost always precedes other manifestations of atherosclerotic cardiovascular disease, including myocardial infarction and stroke. It is common, associated with the presence of modifiable cardiovascular risk factors, and impacted by diet and lifestyle choices. This concise review provides an update on the use of dietary and other lifestyle interventions to improve vasculogenic erectile dysfunction and atherosclerotic cardiovascular disease.
Source: The American Journal of Medicine - November 20, 2020 Category: General Medicine Authors: Robert J Ostfeld, Kathleen Allen, Karen Aspry, Eric J. Brandt, Aaron Spitz, Joshua Liberman, Danielle Belardo, James H. O'Keefe, Monica Aggarwal, Michael Miller, Columbus Batiste, Stephen Kopecky, Beth White, Nikhil Shah, Hussam Hawamdeh, Travis Batts, Ro Tags: Review Source Type: research

High Fluctuation Between Anticoagulants, Frequent Off-Label Dosing, and No Difference Concerning Outcomes: Results of a Real-Life Cohort Study
Recently published studies indicated a high proportion of patients taking direct oral anticoagulants (DOACs) are off-label under- or overdosed. The present study aimed at investigating whether off-label dosages are corrected over time and whether off-label doses are associated with differences in bleeding rates, ischemic stroke, or venous thromboembolism.
Source: The American Journal of Medicine - October 24, 2020 Category: General Medicine Authors: Corinne M. Eschler, Ana Antelo, Georg-Christian Funk, Aristomenis K. Exadaktylos, Gregor Lindner Tags: Clinical Research Study Source Type: research

LDL Cholesterol and Ischemic Stroke in Patients with Nonvalvular Atrial Fibrillation
We examined the association between LDL-C levels and incident stroke in patients with atrial fibrillation treated with direct oral anticoagulants (DOACs).
Source: The American Journal of Medicine - September 28, 2020 Category: General Medicine Authors: Alexander Omelchenko, Tzipi Hornik-Lurie, Hagit Gabay, Saar Minha, Abid Assali, David Pereg Tags: Clinical Research Study Source Type: research

LDL-cholesterol and ischemic stroke in patients with non-valvular atrial fibrillation
We examined the association between LDL-C levels and incident stroke in patients with atrial fibrillation treated with direct oral anticoagulants (DOACs).
Source: The American Journal of Medicine - September 27, 2020 Category: General Medicine Authors: Alexander Omelchenko, Tzipi Hornik-Lurie, Hagit Gabay, Saar Minha, Abid Assali, David Pereg Source Type: research

Peripheral Arterial Disease in Patients with Atrial Fibrillation: The AFFIRM Study
Peripheral arterial disease has been linked with worse outcomes in patients with atrial fibrillation. The aim of this study is to assess the impact of peripheral arterial disease on mortality and stroke in a cohort of patients with atrial fibrillation.
Source: The American Journal of Medicine - September 18, 2020 Category: General Medicine Authors: Antonios Vitalis, Alena Shantsila, Marco Proietti, Rajiv K. Vohra, Mark Kay, Brian Olshansky, Gregory Y.H. Lip Tags: Clinical Research Study Source Type: research

Peripheral arterial disease in patients with atrial fibrillation: The Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study.
Atrial fibrillation and peripheral arterial disease are two conditions associated with high risk of cardiovascular and cerebrovascular complications and mortality.1 –5 There is evidence that coexistence of both these clinical conditions can result to an additive risk of adverse events.6 Indeed, atherosclerotic vascular disease has been linked with stroke, thromboembolism and death in subjects with atrial fibrillation and has been therefore included as one of the components of risk scores, such as the CHA2DS2-VASc score (Congestive Heart failure, Hypertension Age> 75 years, DM, Stroke, Vascular disease) in order to strati...
Source: The American Journal of Medicine - September 17, 2020 Category: General Medicine Authors: Antonios Vitalis, Alena Shantsila, Marco Proietti, Rajiv K. Vohra, Mark Kay, Brian Olshansky, Gregory Y.H. Lip Source Type: research

Corrigendum to “Effectiveness and Safety of Oral Anticoagulants in Adults with Non-valvular Atrial Fibrillation Patients and Concomitant Coronary/Peripheral Artery Disease” American Journal of Medicine 131:09 (2018): 1074-1085.e4
There were 33,269 apixaban-warfarin, 9,345 dabigatran-warfarin, and 42,156 rivaroxaban-warfarin matched pairs, with a median follow-up of 4-5 months. Compared with warfarin, apixaban was associated with lower rates of stroke/systemic embolism (hazard ratio [HR] 0.52; 95% confidence interval [95% CI], 0.43-0.62), major bleeding (HR 0.60; 95% CI, 0.55-0.66) and stroke/myocardial infarction/all-cause mortality (HR 0.70; 95%CI, 0.66-0.74); dabigatran was associated with lower rates of major bleeding (HR: 0.73; 95% CI, 0.62-0.85); dabigatran and rivaroxaban were associated with lower rates of stroke/myocardial infarction/all-ca...
Source: The American Journal of Medicine - August 4, 2020 Category: General Medicine Authors: Renato D. Lopes, Jan Steffel, Manuela Di Fusco, Allison Keshishian, Xuemei Luo, Xiaoyan Li, Cristina Masseria, Melissa Hamilton, Keith Friend, Kiran Gupta, Jack Mardekian, Xianying Pan, Onur Baser, W. Schuyler Jones Tags: Corrigendum Source Type: research

Infection as a trigger for cardiovascular disease
A variety of clinical infections including the current pandemic and a variety of physical events such as bee stings and trauma have been documented as triggers of acute cardiovascular illness such as venous thromboembolism, myocardial infarction, and stroke.1 –12 A number of factors have been proposed to explain this association between infection and acute cardiovascular disease including activation of various inflammatory molecules and platelets, endothelial dysfunction, and/or augmented sympathetic nervous activity with release of high levels of cate cholamines into the circulation.
Source: The American Journal of Medicine - July 6, 2020 Category: General Medicine Authors: Joseph S. Alpert Tags: Commentary Source Type: research

Q Fever, CNS Vasculitis, and Stroke: A Case Report
A 43-year-old male pet shop owner on leflunomide for seronegative rheumatoid arthritis presented locally with strange behavior and aphasia, preceded by flu-like symptoms and high fevers. Initial workup revealed cerebrospinal fluid lymphocytic pleocytosis (22 cells, 74% lymphocytes), for which he was started on empiric antimicrobial therapy. Magnetic resonance imaging of the brain revealed extensive, bilateral ischemic strokes (Figure). A transesophageal echocardiogram was negative. He was then transferred to our institution for further evaluation.
Source: The American Journal of Medicine - May 27, 2020 Category: General Medicine Authors: Jason Maljaars, Santiago Ortega-Gutierrez, Tracey Cho, Amir Shaban Tags: Clinical Communication to the Editor Source Type: research

A Case of Acute Ischemic Stroke and CNS vasculitis in a Patient with Q Fever
A 43-year-old male pet shop owner on leflunomide for seronegative rheumatoid arthritis presented locally with strange behavior and aphasia, preceded by flu-like symptoms and high fevers. Initial workup revealed cerebrospinal fluid lymphocytic pleocytosis (22 cells, 74% lymphocytes), for which he was started on empiric antimicrobial therapy. A brain MRI revealed extensive, bilateral ischemic strokes (Figure 1). A transesophageal echocardiogram (TEE) was negative. He was then transferred to our institution for further evaluation.
Source: The American Journal of Medicine - May 27, 2020 Category: General Medicine Authors: Jason Maljaars, Santiago Ortega-Gutierrez, Tracey Cho, Amir Shaban Tags: Clinical Communication to the Editor Source Type: research

Coma during a febrile illness – Respiratory Syncytial Virus-triggered ischemic stroke
An active 79-year-old woman was admitted in early December in coma.
Source: The American Journal of Medicine - May 18, 2020 Category: General Medicine Authors: Ami Schattner, Yair Glick, Ina Dubin Tags: CCE Source Type: research

Regular Bleeding Risk Assessment Associated with Reduction in Bleeding Outcomes: The mAFA-II Randomized Trial
The mobile atrial fibrillation application (mAFA-II) randomized trial reported that a holistic management strategy supported by mobile health reduced atrial fibrillation-related adverse outcomes. The present study aimed to assess whether regular reassessment of bleeding risk using the Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile international normalized ratio, Elderly, Drugs or alcohol (HAS-BLED) score would improve bleeding outcomes and oral anticoagulant (OAC) uptake.
Source: The American Journal of Medicine - April 11, 2020 Category: General Medicine Authors: Yutao Guo, Deirdre A. Lane, Yundai Chen, Gregory Y.H. Lip, mAF-App II Trial investigators Tags: Clinical Research Study Source Type: research

Regular bleeding risk assessment associated with reduction in bleeding outcomes: The mAFA II randomised trial
Oral anticoagulants (OAC) are highly effective for the prevention of stroke in patients with atrial fibrillation.1,2 However, bleeding events are a detrimental side effect of OAC use, even despite the reduced risk of intracranial haemorrahge with the use of non –vitamin K antagonist oral anticoagulants (NOACs) with major bleeding rates at 2% to 4% and any bleeding of 11%-18% per year.3 Some of these bleeding events are non-clinically relevant bleeding, and overall there is a positive net clinical benefit for using OACs for stroke prevention for the major ity of atrial fibrillation patients.
Source: The American Journal of Medicine - April 11, 2020 Category: General Medicine Authors: Yutao Guo, Deirdre A. Lane, Yundai Chen, Gregory Y.H. Lip, mAF-App II Trial investigators Source Type: research