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Source: The American Journal of Medicine
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Total 259 results found since Jan 2013.
An unusual cause of stroke: Neurosarcoidosis
Source: The American Journal of Medicine - August 28, 2019 Category: General Medicine Authors: Sijie Jason Wang Tags: Diagnostic Dilemma Source Type: research
New-onset atrial fibrillation among patients with infection in the emergency department: A multicentre cohort study of one-year stroke risk
Patients with new-onset atrial fibrillation in relation to infection are frequent in emergency departments (ED) and may require antithrombotic therapy due to increased risk of stroke. Our objective was to describe the one-year risk of stroke in ED patients with infection, new-onset atrial fibrillation and no antithrombotic therapy.
Source: The American Journal of Medicine - August 8, 2019 Category: General Medicine Authors: Tobias Graversgaard Hansen, Anton Potteg ård MScPharm, Axel Brandes, Ulf Ekelund, Helene Kildegaard Jensen, Jakob Lundager Forberg, Mikkel Brabrand, Annmarie Touborg Lassen Tags: Clinical research study Source Type: research
Take-Home Messages From the Recently Updated AHA/ACC Guidelines for Atrial Fibrillation
Atrial fibrillation and congestive heart failure (CHF) are “growth industries” in 21st-century industrial nations. The rapid growth of the geriatric population in these countries plays an important role in the ever-increasing number of patients seen with these 2 clinical entities. Patients with atrial fibrillation are seen on a daily basis in both the c linic and the hospital. The most devastating complication resulting from atrial fibrillation is cerebral arterial embolism with resultant stroke.
Source: The American Journal of Medicine - August 7, 2019 Category: General Medicine Authors: Joseph S. Alpert Tags: Commentary Source Type: research
Varicella-zoster virus vasculopathy leading to multi-focal stroke in an immunocompromised patient
Source: The American Journal of Medicine - July 24, 2019 Category: General Medicine Authors: Sae K. Jang, Natalia E. Castillo Almeida, Randall Ambroz, Wilson Tags: Clinical Communication to the Editor Source Type: research
Central post-stroke pain with Wallenberg syndrome
Source: The American Journal of Medicine - July 23, 2019 Category: General Medicine Authors: Junki Mizumoto Tags: Clinical Communications to the Editor Source Type: research
Cholesterol lowering and stroke: no longer room for pleiotropic effects of statins – confirmation from PCSK9 inhibitor studies
The relationship between cholesterol levels and stroke has been much less clear than between cholesterol levels and coronary heart disease. This is likely mostly due to the inadequate power of older studies and the low intensity of cholesterol-lowering interventions at that time available. Because a reduction in stroke has been, conversely, clearly observed in trials with statins, for long “pleiotropic” effects of such drugs, unrelated to cholesterol lowering, have been invoked. In a previous analysis of all randomized trials of cholesterol-lowering treatments reporting on stroke we had, however, reached the conclusion...
Source: The American Journal of Medicine - July 10, 2019 Category: General Medicine Authors: Tanya Salvatore, Riccardo Morganti, Roberto Marchioli, Raffaele De Caterina Tags: Clinical Research Study Source Type: research
Cardiovascular and cerebrovascular safety of testosterone replacement therapy among aging men with low testosterone levels: a cohort study
We assessed the risk of ischemic stroke, transient ischemic attack, and myocardial infarction associated with testosterone replacement therapy (TRT) among aging men with low testosterone levels.
Source: The American Journal of Medicine - April 2, 2019 Category: General Medicine Authors: Simone Y. Loo, Laurent Azoulay, Rui Nie, Sophie Dell'Aniello, Oriana Hoi Yun Yu, Christel Renoux Tags: Clinical Research Study Source Type: research
Etiological research using observational data, and net clinical benefit. Simplicity and practicality matter
Atrial fibrillation in an elderly patient requires oral anticoagulant (OAC) treatment, and contemporary international guidelines recommend treatment for atrial fibrillation patients at 75years or older.1,2 Substantial evidence (mostly in favour) of non-vitamin K antagonist oral anticoagulants (NOACs), in comparison with warfarin, has emerged over the past decade. In particular, the benefits from a lower risk of intracranial bleeding and the non-requirement for monitoring of anticoagulant effects have driven the uptake of NOACs as the preferred choice for stroke prevention in atrial fibrillation, although some regional differences are evident.
Source: The American Journal of Medicine - March 4, 2019 Category: General Medicine Authors: Peter Br ønnum Nielsen, Iain Buchan, Gregory Y.H. Lip Tags: Editorial Source Type: research
Effectiveness and safety of off-label dose-reduced direct oral anticoagulants in atrial fibrillation
Direct oral anticoagulants (DOACs) reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation but may result in serious bleeding complications. Off-label dose-reduced use of DOAC to mitigate bleeding is common in routine clinical practice although data regarding its consequences on patient outcomes is limited. Therefore, our objective was to evaluate the effectiveness and safety of off-label dose-reduced versus per-label standard-dose DOAC treatment.
Source: The American Journal of Medicine - February 15, 2019 Category: General Medicine Authors: Ronen Arbel, Ruslan Sergienko, Ariel Hammerman, Sari Greenberg-Dotan, Erez Batat, Orly Avnery, Martin H. Ellis Source Type: research
Chronic Myocardial Injury and Risk for Stroke
This study aimed to investigate the association between chronic myocardial injury and stroke.
Source: The American Journal of Medicine - February 1, 2019 Category: General Medicine Authors: Linda Ryd én, Andreas Roos, Martin J Holzmann Tags: Clinical Research Study Source Type: research
Comparative stroke, bleeding, and mortality risks in older Medicare patients treated with oral anticoagulants for nonvalvular atrial fibrillation
Non-vitamin K antagonist oral anticoagulants (NOACs) are alternatives to warfarin in patients with nonvalvular atrial fibrillation. Randomized trials compared NOACs to warfarin, but none have compared individual NOACs against each other for safety and effectiveness.
Source: The American Journal of Medicine - January 9, 2019 Category: General Medicine Authors: David J. Graham, Elande Baro, Rongmei Zhang, Jiemin Liao, Michael Wernecke, Marsha E. Reichman, Mao Hu, Onyekachukwu Illoh, Yuqin Wei, Margie R. Goulding, Yoganand Chillarige, Mary Ross Southworth, Thomas E. MaCurdy, Jeffrey A. Kelman Tags: Clinical Research Study Source Type: research
The Reply
When preparing our review of patent foramen ovale closures,1 we were not aware of the 2013 report by Kent et al.,2 cited by Wani and colleagues in their comments. We would certainly agree that a cryptogenic stroke in a young patient without risk factors for cerebrovascular disease is more likely to be due to paradoxical embolism than a cryptogenic stroke in an elderly patient with risk factors for cerebrovascular disease.
Source: The American Journal of Medicine - October 27, 2018 Category: General Medicine Authors: James E Dalen Tags: Letter Source Type: research
RoPES, Strokes and Closures
We read with great interest the review article by Dalen and Alpert regarding “Which Patent Foramen Ovales Need Closure to Prevent Cryptogenic Strokes?”1 The authors have provided a succinct contemporary review and have also distinctively tabulated the results of the path-defining trials in this somewhat contentious field. The main message provided by the authors is that in patients with cryptogenic stroke, a patent foramen ovale associated with an atrial septal aneurysm should be closed and that closure is not indicated when an atrial septal aneurysm is absent.
Source: The American Journal of Medicine - October 27, 2018 Category: General Medicine Authors: Adil S. Wani, Suhail Q. Allaqaband, M. Fuad Jan Tags: Letter Source Type: research
Management of Acute Ischemic Stroke
The treatment of acute ischemic stroke has undergone a revolution recently with the publication of five positive thrombectomy trials in the early time window, 0-6 hours from stroke onset in 2015 and the more recent publication of two positive late window trials that included carefully selected patients up to 24 hours from stroke onset.1-3 The treatment efficacy of thrombectomy was highly robust in both time windows and the benefits can likely be expanded to less strictly selected patients. The treatment of acute ischemic stroke with thrombectomy built upon the more modest benefits observed previously with i.v.
Source: The American Journal of Medicine - October 25, 2018 Category: General Medicine Authors: Yunyun Xiong, Bharti Manwani, Marc Fisher Tags: Review Source Type: research
Concomitant use of direct oral anticoagulants with antiplatelet agents and the risk of major bleeding in patients with non-valvular atrial fibrillation
Direct oral anticoagulants (DOACs) are increasingly being used for ischemic stroke prevention among patients with non-valvular atrial fibrillation,1,2 partly because of their favorable efficacy and safety compared with vitamin K antagonists (VKAs).3 However, the safety of DOACs in patients with non-valvular atrial fibrillation requiring additional use of antiplatelet agents remains uncertain. This is important, as up to 30% of patients with non-valvular atrial fibrillation may receive concomitant treatments of oral anticoagulants with antiplatelets due to comorbid cardiovascular conditions.
Source: The American Journal of Medicine - October 25, 2018 Category: General Medicine Authors: Antonios Douros, Christel Renoux, Hui Yin, Kristian B. Filion, Samy Suissa, Laurent Azoulay Tags: Clinical Research Study Source Type: research
