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Homeostasis model assessment of insulin resistance in relation to the poor functional outcomes in nondiabetic patients with ischemic stroke.
Conclusion High HOMA-IR index is associated with a poor functional outcome in nondiabetic patients with acute ischemic stroke. PMID: 29588341 [PubMed - as supplied by publisher]
Source: Bioscience Reports - March 27, 2018 Category: Biomedical Science Authors: Li S, Yin C, Zhao W, Zhu H, Xu D, Xu Q, Jiao Y, Wang X, Qiao H Tags: Biosci Rep Source Type: research

Exploring the potential value of miR-148b, miR-151b and miR-27b-3p as biomarkers in acute ischemic stroke.
Abstract Cerebrovascular disease is the main cause of death in the world. Here, we explored whether circulating serum miR-148b-3p, miR-151b and miR-27b-3p could be as potential diagnostic biomarkers for diagnosing acute ischemic stroke. Seventy-seven IS patients and 42 healthy controls matched for age and sex were enrolled in this study. Blood samples were drawn from IS patients within the 24 h. The correlation analysis was performed by Spearman. The ability to distinguish patients from healthy controls was determined by receiver operating characteristic (ROC) curve. The expression of circulating serum miR-148b-3p...
Source: Bioscience Reports - October 25, 2018 Category: Biomedical Science Authors: Cheng X, Kan P, Ma Z, Wang Y, Song W, Huang C, Zhang B Tags: Biosci Rep Source Type: research

Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite
Conclusions: These results suggest that insulin renders diabetic rats resistant to acute ischemic stroke by arresting NO reaction with superoxide to form peroxynitrite.
Source: Journal of Biomedical Science - September 16, 2014 Category: Biomedical Science Authors: Li-Man HungJiung-Pang HuangJiuan-Miaw LiaoMeng-Hsuan YangDai-Er LiYuan-Ji DayShiang-Suo Huang Source Type: research

Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke
ConclusionsWe found that serum levels of CCL-23, CXCL-12, IGFBP-6, IL-5, LYVE-1, PAI-1, PDGF-AA, ST-2, and TNF- α at admission were associated with post-thrombolytic ENI in stroke. The role of biomarkers warrants further investigation. Trial registrationClinical Trial Registration: https://www.clinicaltrials.gov; identifier: NCT02854592.
Source: PLoS One - October 31, 2022 Category: Biomedical Science Authors: Yu Cui Source Type: research

Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia
Conclusions These findings suggest that angiogenesis pathways are dysregulated following birth asphyxia and are putatively involved in brain injury pathology and recovery.
Source: PLoS One - May 21, 2015 Category: Biomedical Science Authors: Henna Shaikh et al. Source Type: research

Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis.
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure
ConclusionWe propose PRIP as a new therapeutic target for controlling obesity or developing novel anti-obesity drugs.
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Association between Coronary Artery Spasm and the risk of incident Diabetes: A Nationwide population-based Cohort Study
Conclusion: CAS is a risk factor for incident diabetes regardless of sex. However, females aged <50 years have a more apparent risk for CAS-related diabetes than old females, which is not observed in males. The median time of 2.9 years to incident diabetes warrants close follow-up.PMID:34104095 | PMC:PMC8176166 | DOI:10.7150/ijms.57987
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Ming-Jui Hung Nen-Chung Chang Patrick Hu Tien-Hsing Chen Chun-Tai Mao Chi-Tai Yeh Ming-Yow Hung Source Type: research

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