Filtered By:
Drug: Insulin
Education: Study
This page shows you your search results in order of date. This is page number 18.
Order by Relevance | Date
Total 1426 results found since Jan 2013.
Post-Stroke Administration of L-4F Promotes Neurovascular and White Matter Remodeling in Type-2 Diabetic Stroke Mice
Patients with type 2 diabetes mellitus (T2DM) exhibit a distinct and high risk of ischemic stroke with worse post-stroke neurovascular and white matter (WM) prognosis than the non-diabetic population. In the central nervous system, the ATP-binding cassette transporter member A 1 (ABCA1), a reverse cholesterol transporter that efflux cellular cholesterol, plays an important role in high-density lipoprotein (HDL) biogenesis and in maintaining neurovascular stability and WM integrity. Our previous study shows that L-4F, an economical apolipoprotein A member I (ApoA-I) mimetic peptide, has neuroprotective effects via alleviati...
Source: Frontiers in Neurology - April 28, 2022 Category: Neurology Source Type: research
Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke
In conclusion, Zfp580 differentially controls paracrine and endocrine Igf1 and Igfbp3 after stroke. Inhibition of Zfp580 might be a new treatment target leading to increased activity of Igf1 to improve stroke outcome.
Source: Frontiers in Physiology - April 26, 2022 Category: Physiology Source Type: research
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
ConclusionWe provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.
Source: Frontiers in Endocrinology - April 22, 2022 Category: Endocrinology Source Type: research
IJERPH, Vol. 19, Pages 4807: Stroke Risk Factors of Stroke Patients in China: A Nationwide Community-Based Cross-Sectional Study
Conclusions: The most common risk factors for community stroke patients in China are hypertension, dyslipidemia, and overweight or obesity. The stroke community patients’ suboptimal awareness and treatment of hypertension, and suboptimal awareness, treatment, and control of diabetes, and dyslipidemia are significant problems in China.
Source: International Journal of Environmental Research and Public Health - April 15, 2022 Category: Environmental Health Authors: Jingyi Chen Qianrang Zhu Lianlong Yu Yuqian Li Shanshan Jia Jian Zhang Tags: Article Source Type: research
Impact of Sarcopenia on Functional Outcomes Among Patients With Mild Acute Ischemic Stroke and Transient Ischemic Attack: A Retrospective Study
CONCLUSIONS: In this study, the prevalence of sarcopenia in patients with stroke was lower than most of previous studies and patients with sarcopenia showed higher likelihood for unfavorable functional outcomes at 90 days after acute ischemic stroke or TIA. Further investigation of the interventions for treating sarcopenia and its impact on the outcome of ischemic stroke patients is needed.PMID:35370897 | PMC:PMC8964497 | DOI:10.3389/fneur.2022.841945
Source: Atherosclerosis - April 4, 2022 Category: Cardiology Authors: Hyungwoo Lee Il Hyung Lee JoonNyung Heo Minyoul Baik Hyungjong Park Hye Sun Lee Hyo Suk Nam Young Dae Kim Source Type: research
Triglyceride-Glucose Index Is Related to Carotid Plaque and Its Stability in Nondiabetic Adults: A Cross-Sectional Study
ConclusionOur findings suggested that the TyG index was significantly associated with carotid plaque and might be a useful indicator for the early identification of carotid plaque in nondiabetic subjects.
Source: Frontiers in Neurology - March 24, 2022 Category: Neurology Source Type: research
Cardiovascular Outcomes in Sleep-Disordered Breathing: Are We Under-estimating?
Obstructive sleep apnea is a growing health concern, affecting nearly one billion people worldwide; increasingly recognized as an independent cardiovascular risk factor associated with incident obesity, insulin resistance, hypertension, arrhythmias, stroke, coronary artery disease, and heart failure. The prevalence of obstructive sleep apnea could be underestimated in the previous studies, leading to only modest predictions of cardiovascular outcomes. Using more physiologic data will increase sensitivity for the diagnosis of obstructive sleep apnea. Individuals at high risk of obstructive sleep apnea should be identified s...
Source: Frontiers in Neurology - March 15, 2022 Category: Neurology Source Type: research
Impact of Sarcopenia on Functional Outcomes Among Patients With Mild Acute Ischemic Stroke and Transient Ischemic Attack: A Retrospective Study
ConclusionsIn this study, the prevalence of sarcopenia in patients with stroke was lower than most of previous studies and patients with sarcopenia showed higher likelihood for unfavorable functional outcomes at 90 days after acute ischemic stroke or TIA. Further investigation of the interventions for treating sarcopenia and its impact on the outcome of ischemic stroke patients is needed.
Source: Frontiers in Neurology - March 15, 2022 Category: Neurology Source Type: research
Efficacy of Lower Doses of Pioglitazone after Stroke or Transient Ischemic Attack In Patients with Insulin Resistance
CONCLUSIONS: Lower doses of pioglitazone appear to confer much of the benefit with less adverse effects than the full dose. Further study is needed to confirm these findings so that clinicians may optimize dosing of this secondary prevention strategy in stroke patients. This article is protected by copyright. All rights reserved.PMID:35253334 | DOI:10.1111/dom.14687
Source: Atherosclerosis - March 7, 2022 Category: Cardiology Authors: J David Spence Catherine Viscoli Walter N Kernan Lawrence H Young Karen Furie Ralph DeFronzo Muhammad Abdul-Ghani Paresh Dandona Silvio E Inzucchi Source Type: research
Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases
Int J Mol Sci. 2022 Feb 21;23(4):2397. doi: 10.3390/ijms23042397.ABSTRACTDiabetes mellitus is a comprehensive expression to identify a condition of chronic hyperglycemia whose causes derive from different metabolic disorders characterized by altered insulin secretion or faulty insulin effect on its targets or often both mechanisms. Diabetes and atherosclerosis are, from the point of view of cardio- and cerebrovascular risk, two complementary diseases. Beyond shared aspects such as inflammation and oxidative stress, there are multiple molecular mechanisms by which they feed off each other: chronic hyperglycemia and advanced...
Source: Atherosclerosis - February 26, 2022 Category: Cardiology Authors: Carlo Domenico Maida Mario Daidone Gaetano Pacinella Rosario Luca Norrito Antonio Pinto Antonino Tuttolomondo Source Type: research
Influence of the Triglyceride-Glucose Index on Adverse Cardiovascular and Cerebrovascular Events in Prediabetic Patients With Acute Coronary Syndrome
ConclusionsThe TyG index independently predicts future MACCEs and may be an important prognostic indicator for patients with prediabetes and ACS.
Source: Frontiers in Endocrinology - February 22, 2022 Category: Endocrinology Source Type: research
Triglyceride-Glucose Index and Intravenous Thrombolysis Outcomes for Acute Ischemic Stroke: A Multicenter Prospective –Cohort Study
ConclusionThis study supports the strong association between the increased TyG index and increased unfavorable functional outcomes at 90 days in patients with acute ischemic stroke treated with IVT. These findings were found to be robust in patients with moderate and high stroke severity.
Source: Frontiers in Neurology - February 14, 2022 Category: Neurology Source Type: research
