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Contrast conservation measures during the global iohexol contrast shortage crisis did not affect stroke thrombectomy outcomes
Conclusions Modifying stroke workflow to adapt to the current global shortage in iohexol is feasible. Using diluted iohexol (50% contrast mixed with 50% heparinized saline) did not affect MT outcomes.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Almallouhi, E., Sattur, M., Lajthia, O., Kicielinski, K. P., Holmstedt, C., Lena, J. R., Al Kasab, S., Spiotta, A. M. Tags: Ischemic stroke Source Type: research

Best Practice Recommendations for Stroke Vascular Imaging During Iodinated Contrast Shortage
GE Healthcare© announced on April 19, 2022, that their main factory and distributor of iodinated contrast had experienced a temporary shutdown because of COVID-19 outbreak in Shanghai, China. This, along with other supply chain issues, led to a worldwide shortage of iodinated contrast agents, Omnipaque and Visipaque. Our Comprehensive Stroke Center was confronted with the cascading effect of this iodinated contrast material shortage. We took immediate steps to revise our protocols and processes to continue to provide high-quality care to our stroke patients. A multidisciplinary working group comprised of representativ...
Source: Neurology Clinical Practice - March 3, 2023 Category: Neurology Authors: Bhole, R., Solenski, N. J., Donahue, J. H., Kellogg, R. T., Roach, N. N., Chapman, S. N., Worrall, B. B., Evans, A. J., Patel, S. H., Mukherjee, S., Park, M. S., Southerland, A. M. Tags: Decision analysis, Medical care, All Cerebrovascular disease/Stroke, All Practice Management Commentary Source Type: research

O-042 Incidence of periprocedural stroke with radial access for diagnostic cerebral angiograms
ConclusionIn our experience, transradial access for diagnostic cerebral angiograms was associated with a low but not neglectable incidence of periprocedural strokes when compared to the traditional femoral approach. Patient vascular anatomy should be evaluated prior to selection of vascular access and patients should be made aware of the possibility of a slightly higher possibility of periprocedural stroke with transradial access.Abstract O-042 Table 1 Patient Age Access Vessels catheterized Catheter used Radial Medication Contrast Fluoro Time Platelet Count INR GFR COVID Status Stroke Symptoms NIHSS Imaging performed 1 5...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kuhn, A., Singh, J., de Macedo Rodrigues, K., Massari, F., Puri, A. Tags: SNIS 19th annual meeting oral abstracts Source Type: research

Navigating Supply Chain Disruptions of Iodinated Contrast Agent for Neuroimaging and How Business Intelligence Can Help the Decision Process ADULT BRAIN
SUMMARY: A recent coronavirus disease 2019–related shutdown of the main production facility of iohexol in China has led to massive shortages of iodinated contrast material across the globe. This shortage has also jeopardized neuroimaging. In this article, we describe remedies to reduce iodinated contrast material use for stroke imaging, which is its primary use in neuroimaging, that we have implemented in our hospital network.
Source: American Journal of Neuroradiology - July 7, 2022 Category: Radiology Authors: Bammer, R., Amukotuwa, S. A. Tags: ADULT BRAIN Source Type: research

Effects of dapagliflozin and gliclazide on the cardiorenal axis in people with type 2 diabetes
Conclusion: Dapagliflozin seemingly influences systemic and renal hemodynamics independently and beyond glucose lowering in people with type 2 diabetes. This clinical trial was registered at https://clinicalTrials.gov (ID: NCT02682563).
Source: Journal of Hypertension - August 13, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Study on the Correlation between Barium Radiography and Pulmonary Infection rate in the Evaluation of Swallowing Function
CONCLUSIONS: During the videofluoroscopic swallowing study of dysphagia after stroke, barium sulfate can enhance the pneumonia incidence, and Iohexol can be widely applied in videofluoroscopic swallowing study.
Source: Clinics - June 18, 2018 Category: General Medicine Source Type: research

Differentiation of Clot Composition Using Conventional and Dual-Energy Computed Tomography
ConclusionThe fibrin content in blood clots is strongly associated with contrast uptake. As previously shown, the density of the clot formations in native CT scans is dependent on the RBC. Our data show that CT density and relative enhancement of clots are independent determinants of clot composition. Using both variables in the CT workup of acute ischemic stroke has the potential to have a  decisive impact on patient stratification for treatment.
Source: Clinical Neuroradiology - May 23, 2017 Category: Neurology Source Type: research

Nongated Cardiac Computed Tomographic Angiograms for Detection of Embolic Sources in Acute Ischemic Stroke Clinical Sciences
Conclusions—Including the heart and ascending aorta in a routine non–ECG-gated computed tomographic angiogram enhances an existing imaging modality, with no increased incidence of contrast-induced nephropathy and minimal increase in radiation dose. This may help in the detection of high-risk cardiac and aortic sources of embolism in acute stroke patients.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Leonard L.L. Yeo, Staffan Holmin, Tommy Andersson, Erik Lundstrom, Anil Gopinathan, Er Luen Lim, Benȷamin S.H. Leong, Win Sen Kuan, Eric Ting, Benȷamin Y.Q. Tan, Sterling Ellis Eide, Edgar L.K. Tay Tags: Computerized Tomography (CT), Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Mesenchymal stromal cell secretomes are modulated by suspension time, delivery vehicle, passage through catheter, and exposure to adjuvants
Discussion Exposure of MSCs to certain types of vehicles or additives changes the profile of cytokine secretion. The activation phenotype of MSCs may therefore be affected by the vehicles used for these cells or the exposure to the adjuvants used in their administration.
Source: Cytotherapy - November 14, 2016 Category: Cytology Source Type: research

Correlation studies of barium on pulmonary infection under the assessment of VFSS.
In conclusion, in the VFSS of dysphagia after stroke and barium sulfate increased the incidence of pneumonia, and that iohexol was widely used in video fluoroscopy. PMID: 26893627 [PubMed - as supplied by publisher]
Source: Experimental and Therapeutic Medicine - February 21, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Outcome Differences between Intra-Arterial Iso- and Low-Osmolality Iodinated Radiographic Contrast Media in the Interventional Management of Stroke III Trial INTERVENTIONAL
CONCLUSIONS: While data favoring the use of iso-osmolal iodixanol for reperfusion of M1 occlusion following IV rtPA are inconclusive, potential pathophysiologic mechanisms suggesting clinical benefit warrant further investigation.
Source: American Journal of Neuroradiology - November 13, 2015 Category: Radiology Authors: Tomsick, T. A., Foster, L. D., Liebeskind, D. S., Hill, M. D., Carrozella, J., Goyal, M., von Kummer, R., Demchuk, A. M., Dzialowski, I., Puetz, V., Jovin, T., Morales, H., Palesch, Y. Y., Broderick, J., Khatri, P., Yeatts, S. D., for the IMS III Investig Tags: INTERVENTIONAL Source Type: research

Iodinated Contrast Does Not Alter Clotting Dynamics in Acute Ischemic Stroke as Measured by Thromboelastography Clinical Sciences
Conclusions— Our data do not support an effect of iodinated contrast agents on clot formation or tPA activity.
Source: Stroke - January 27, 2014 Category: Neurology Authors: McDonald, M. M., Archeval-Lao, J. M., Cai, C., Peng, H., Sangha, N., Parker, S. A., Wetzel, J., Riney, S. A., Cherches, M. F., Guthrie, G. J., Roper, T. C., Kawano-Castillo, J. F., Pandurengan, R., Rahbar, M. H., Grotta, J. C. Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research