Filtered By:
Condition: Ischemic Stroke
Drug: Diprivan

This page shows you your search results in order of date.

Order by Relevance | Date

Total 35 results found since Jan 2013.

Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Neurochemical Research - November 19, 2022 Category: Neuroscience Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research

Propofol rescued astrocytes from LPS-induced inflammatory response via blocking LncRNA-MEG3/NF- κB axis
CONCLUSION: These findings demonstrated that LncRNA-MEG3 acted as a positive regulator of NF-κB, mediated the neuroprotection of propofol in LPS-triggered astrocytes injury.PMID:35297349 | DOI:10.2174/1567202619666220316112509
Source: Current Neurovascular Research - March 17, 2022 Category: Neurology Authors: Fan Zhang Zhihua Wang Bei Sun Yan Huang Cheng Chen Jie Hu Longyan Li Pingping Xia Zhi Ye Source Type: research

Evaluation of energy intake compared to indirect calorimetry requirements in critically ill patients with acute brain injury
CONCLUSION: In this population, patients had lower energy intake compared to their caloric needs determined by IC during the first 72 hours of admission but attained 7-day goals. Future studies should investigate barriers to improve caloric delivery in this patient population. This article is protected by copyright. All rights reserved.PMID:34665471 | DOI:10.1002/jpen.2282
Source: JPEN Journal Of Parenteral And Enteral Nutrition - October 19, 2021 Category: Nutrition Authors: Casey C May Emily A Harris Yousef Hannawi Keaton S Smetana Source Type: research

Assessment of Anesthesia Practice Patterns for Endovascular Therapy for Acute Ischemic Stroke: A Society for Neuroscience in Anesthesiology and Critical Care (SNACC) Member Survey
Conclusions: There is wide variation in anesthesia technique and hemodynamic management during EVT for AIS, and no consensus on the choice of, or preferred medications for, GA or CS, or target blood pressure and management of hypotension during the procedure.
Source: Journal of Neurosurgical Anesthesiology - September 19, 2021 Category: Anesthesiology Tags: Short Reports Source Type: research

Propofol Ameliorates Microglia Activation by Targeting MicroRNA-221/222-IRF2 Axis
CONCLUSIONS: Our study highlights the critical function of miR-221/222, which inhibited Irf2 translation, in the anti-inflammatory effects of propofol, and provides a new perspective for the molecular mechanism of propofol-mediated neuroprotective effect.PMID:34423051 | PMC:PMC8373515 | DOI:10.1155/2021/3101146
Source: Journal of Immunology Research - August 23, 2021 Category: Allergy & Immunology Authors: Xi Xiao Yuanyuan Hou Wei Yu Sihua Qi Source Type: research

Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke
Source: Neuroscience Bulletin - March 20, 2021 Category: Neuroscience Source Type: research

Intravenous Propofol Versus Volatile Anesthetics For Stroke Endovascular Thrombectomy
Conclusion: In stroke patients undergoing endovascular thrombectomy treated using general anesthesia, there may be a differential effect between intravenous propofol and volatile inhalational agents. These results should be considered hypothesis-generating and be tested in future randomized controlled trials.
Source: Journal of Neurosurgical Anesthesiology - December 11, 2020 Category: Anesthesiology Tags: Clinical Investigations Source Type: research