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Condition: Ischemic Stroke
Drug: Aspirin
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Total 2045 results found since Jan 2013.
Recombinant tissue-type plasminogen activator (rt-PA) effectively restores neurological function and improves prognosis in acute ischemic stroke
CONCLUSION: Compared with conventional pharmacological regimens, additional rt-PA intravenous thrombolytic therapy improves the clinical outcome of patients with acute ischemic stroke, promotes neurological recovery, and enhances patient prognosis without increasing the risk of patient-related adverse events.PMID:37303683 | PMC:PMC10251022
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Shouyun Zhang Dezhen Wang Lin Li Source Type: research
Cardiovascular risk in vasculitis
Best Pract Res Clin Rheumatol. 2023 Jun 9:101831. doi: 10.1016/j.berh.2023.101831. Online ahead of print.ABSTRACTThe present review summarizes the burden, risk factors, biomarkers of and therapeutic consideration for cardiovascular disease in systemic vasculitis. Ischemic heart disease (IHD) and stroke are intrinsic features of Kawasaki disease, Takayasu arteritis, Giant Cell Arteritis (GCA), and Behcet's disease. The risk of IHD and stroke is increased in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and cryoglobulinemic vasculitis. Behcet's disease could present with venous thromboembolism. The risk of...
Source: Cell Research - June 11, 2023 Category: Cytology Authors: Durga Prasanna Misra Aman Sharma George A Karpouzas George D Kitas Source Type: research
Investigation of Combined Carotid Endarterectomy and Coronary Artery Bypass Graft Surgery Outcomes and Adverse Event Risk Factors in the Vascular Quality Initiative
CONCLUSIONS: Combined CEA and CABG provides excellent long-term mortality prevention in patients with co-existing severe coronary and carotid atherosclerosis. Simultaneous CEA and CABG provides equivalent stroke prevention and long-term survival to both a cohort of patients undergoing coronary revascularization within 5 years of CEA and patients undergoing isolated CEA or CABG in the literature. The two most impactful modifiable risk factors towards long-term stroke and mortality prevention for patients undergoing simultaneous CEA-CABG are patch placement at CEA site and adherence to statin medication therapy.PMID:37303074...
Source: Atherosclerosis - June 11, 2023 Category: Cardiology Authors: Ashley Penton Jonathan Lin Grant Kolde Matthew DeJong Matthew Blecha Source Type: research
Short Versus Long-Term Dual Antiplatelet Therapy in Patients at High Bleeding Risk Undergoing PCI in Contemporary Practice: A Systemic Review and Meta-analysis
ConclusionShort-term DAPT after PCI in HBR patients was associated a reduction in major bleeding events and similar ischemic outcomes. However, a higher risk of ischemic stroke and MI at 1 year of follow-up was seen in some subsets.
Source: Cardiology and Therapy - June 1, 2023 Category: Cardiology Source Type: research
Effects of remote ischemic postconditioning on the pro-inflammatory neutrophils of peripheral blood in acute cerebral infarction
CONCLUSION: More severe cerebral infarction was associated with a higher percentage of pro-inflammatory neutrophils. The neuroprotective effect of RIPostC may partly be exerted through gene regulation to reduce pro-inflammatory neutrophils.PMID:37253636 | DOI:10.18632/aging.204751
Source: Aging - May 30, 2023 Category: Biomedical Science Authors: Zhen Liang Lin Qiu Xu Wang Liangshu Feng Yulei Hao Feng Yang Di Ma Jiachun Feng Source Type: research
Immature platelets and cardiovascular events in patients with stable coronary artery disease
Platelets. 2023 Dec;34(1):2217960. doi: 10.1080/09537104.2023.2217960.ABSTRACTMany patients with coronary artery disease (CAD) have reduced the effect of aspirin, which may partly be explained by immature platelets. We aimed to investigate whether immature platelet markers can predict cardiovascular events in a large cohort of stable CAD patients. A total of 900 stable CAD patients were included and followed for a median of 3 years. We measured markers of immature platelets (platelet count, immature platelet count, immature platelet fraction, mean platelet volume, platelet distribution width, platelet mass, and thrombopoie...
Source: Platelets - May 29, 2023 Category: Hematology Authors: Oliver Buchhave Pedersen Sanne B øjet Larsen Steen Dalby Kristensen Anne-Mette Hvas Erik Lerkevang Grove Source Type: research
Acute carotid stenting plus aspirin during thrombectomy of tandem occlusions: A matched case-control study
CONCLUSIONS: Acute CAS plus Aspirin during thrombectomy for tandem occlusion stroke appears safe. Randomized trials are warranted to confirm these findings.PMID:37229632 | DOI:10.1177/15910199231175375
Source: Interventional Neuroradiology - May 25, 2023 Category: Radiology Authors: Mohamed-Isma ël Yahia Gaultier Marnat Stephanos Finitsis Igor Sibon Jean-Marc Olivot Raoul Pop Mohammad Anadani S ébastien Richard Benjamin Gory Source Type: research
Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY): protocol for a multicentre, randomised controlled trial
DISCUSSION: The STRATEGY trial will assess whether tirofiban combined with aspirin is effective and safe in preventing recurrence and END in patients with PAI.TRIAL REGISTRATION NUMBER: NCT05310968.PMID:37220998 | DOI:10.1136/svn-2022-002284
Source: Atherosclerosis - May 23, 2023 Category: Cardiology Authors: Xiaoling Liao Shuo Feng Yicong Wang Yuesong Pan Weiqi Chen Hui Qu Xingquan Zhao Liping Liu Yongjun Wang Yilong Wang Source Type: research
Effects of long-term regular oral aspirin combined with atorvastatin to prevent ischemic stroke on human gut microbiota
CONCLUSIONS: Our findings indicated that long-term regular oral aspirin and atorvastatin modulate the human gut microbiota. Taking these drugs may affect the preventive effect of ischemic stroke by changing the abundance of specific gut microbiota.PMID:37201625 | DOI:10.1016/j.ejphar.2023.175800
Source: European Journal of Pharmacology - May 18, 2023 Category: Drugs & Pharmacology Authors: Guangtang Chen Zili Wang Wenxue Song Yidong Liao Xudong Wang Chen Chen Jiang Ming Junshuan Cui Kaya Xu Source Type: research
Prevention of Venous Thromboembolism in Medical Patients with Thrombocytopenia or with Platelet Dysfunction: The Last 10 Years
Semin Thromb Hemost DOI: 10.1055/s-0043-1769013Current guideline recommendations for primary prophylaxis of venous thromboembolism (VTE) are based on randomized clinical trials that usually exclude subjects at a potentially high risk of bleeding complications. For this reason, no specific guideline is available for thromboprophylaxis in hospitalized patients with thrombocytopenia and/or platelet dysfunction. However, except in patients with absolute contraindications to anticoagulant drugs, antithrombotic prophylaxis should always be considered, for example, in hospitalized cancer patients with thrombocytopenia, especially...
Source: Seminars in Thrombosis and Hemostasis - May 18, 2023 Category: Hematology Authors: Tufano, Antonella Brenner, Benjamin Tags: Review Article Source Type: research
