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Drug: Lisinopril

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Total 44 results found since Jan 2013.

Clinical Reasoning: A 58-year-old man with right facial numbness
A 58-year-old man with a history of uncontrolled hypertension presented to the emergency department for evaluation of right facial numbness. He went to bed feeling normal and woke up with numbness and tingling in the right face limited to the right perioral area. He denied any associated neurologic symptoms or having similar experiences in the past. His medical history was significant for uncontrolled hypertension; surgical history was negative. Social history was pertinent for occasional alcohol use, but no smoking or drug use. Family history was significant for hypertension in both parents and essential tremor in his sis...
Source: Neurology - October 19, 2015 Category: Neurology Authors: Egan, K. A., Sevush-Garcy, J. L., Lukovic, E., Sherzai, A. Z., Yaghi, S. Tags: Tremor, All Cerebrovascular disease/Stroke, Infarction RESIDENT AND FELLOW SECTION Source Type: research

Assessing Patient Decision-Making Capacity: It’s About the Thought Process
Fred Jones is a 64-year-old man who presents to the emergency department with visual changes and left-sided facial numbness that started 2 hours earlier, after an argument with his wife. He states, “I want to make sure I’m not having a stroke.” His medical history is significant for hypertension. His medications include lisinopril, hydrochlorothiazide, and simvastatin. He is being evaluated for a cerebral vascular accident (CVA) with an onset of symptoms of less than 4 hours. Nursing assessment finds a National Institutes of Health Stroke Scale score of 1, with the loss of left upper quadrant peripheral visual fields.
Source: Journal of Emergency Nursing: JEN - January 9, 2015 Category: Nursing Authors: Melanie A. Mitchell Tags: Clinical Source Type: research

Paramedic Initiated Lisinopril For Acute Stroke Treatment (PIL-FAST): results from the pilot randomised controlled trial
Conclusions It is possible to conduct a paramedic initiated double-blind RCT of a treatment for acute stroke. However, to perform a definitive RCT in a reasonable timescale, a large number of trained paramedics across several ambulance services would be needed to recruit the number of patients likely to be required. Clinical trial registration http://www.clinicaltrials.gov. Unique identifier: NCT01066572.
Source: Emergency Medicine Journal - November 19, 2014 Category: Emergency Medicine Authors: Shaw, L., Price, C., McLure, S., Howel, D., McColl, E., Younger, P., Ford, G. A. Tags: Open access, Stroke, Hypertension, Resuscitation Original article Source Type: research

Pharmacogenetic effects of ‘candidate gene complexes’ on stroke in the GenHAT study
ObjectiveThe aim of this study was to investigate whether there is a genotype-by-treatment interaction in patients experiencing stroke and treated with one of three antihypertensive drugs, that is chlorthalidone, amlodipine, or lisinopril. Participants and methodsA population of 436 African Americans and 539 whites who had experienced stroke in the GenHAT study were genotyped for 768 single nucleotide polymorphisms (SNPs) in 280 candidate genes. To detect a genotype-by-treatment interaction, we used the Pearson’s χ2-test to assess whether the genotype frequencies differed at the single SNP level for the three drug treat...
Source: Pharmacogenetics and Genomics - October 9, 2014 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Stroke Outcomes Among Participants Randomized To Chlorthalidone, Amlodipine Or Lisinopril In Allhat
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind, practice-based, active-control, comparative effectiveness trial in 33,357 high-risk hypertensive participants.
Source: Journal of the American Society of Hypertension - August 19, 2014 Category: Cardiology Authors: José-Miguel Yamal, Suzanne Oparil, Barry R. Davis, Michael H. Alderman, David A. Calhoun, William C. Cushman, Herbert F. Fendley, Stanley S. Franklin, Gabriel B. Habib, Sara L. Pressel, Jeffrey L. Probstfield, Sithiporn Sastrasinh, ALLHAT Collaborative R Source Type: research

Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT
Objective:Epidemiologically, there is a strong relationship between BMI and blood pressure (BP) levels. We prospectively examined randomization to first-step chlorthalidone, a thiazide-type diuretic; amlodipine, a calcium-channel blocker; and lisinopril, an angiotensin-converting enzyme inhibitor, on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [kg/m2; normal weight (BMI 30)]. Methods:In a randomized, double-blind, practice-based Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, 33 357 hypertensive participants, aged at least 55 years, were followed...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research

Prolonged anticoagulant activity of rivaroxaban in a polymorbid elderly female with non-convulsive epileptic state
Conclusion: Health care providers should consider renal function, concomitant medication, polymorbidity and age prior to prescribing rivaroxaban. Care has to be taken when prescribing rivaroxaban to patients who are different from those included in the ROCKET AF trial.
Source: Heart and Lung - May 1, 2014 Category: Intensive Care Authors: Claudia Stöllberger, Josef Finsterer Tags: Care of Patients with Comorbid Disorders Source Type: research

Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial
Conclusions Among maintenance dialysis patients with hypertension and left ventricular hypertrophy, atenolol-based antihypertensive therapy may be superior to lisinopril-based therapy in preventing cardiovascular morbidity and all-cause hospitalizations. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases; ClinicalTrials.gov number: NCT00582114)
Source: Nephrology Dialysis Transplantation - February 28, 2014 Category: Urology & Nephrology Authors: Agarwal, R., Sinha, A. D., Pappas, M. K., Abraham, T. N., Tegegne, G. G. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Orolingual Angioedema with Alteplase Administration for Treatment of Acute Ischemic Stroke
A 68-year-old African-American male with a history of hypertension and gout (on lisinopril for approximately 1 year) presented to the Emergency Department with 2.5 h of left-arm weakness and numbness. Of note, the patient was in newly discovered rapid atrial fibrillation and, in light of persistent neurologic deficits (National Institutes of Health Stroke Scale 16→7) within 4.5 h, the decision was made to administer i.v. tissue plasminogen activator (tPA) for treatment of presumed embolic right middle cerebral artery stroke. Approximately 30 min post infusion, the patient developed severe diffuse orolingual angioedema of...
Source: The Journal of Emergency Medicine - May 13, 2013 Category: Emergency Medicine Authors: Elizabeth M. Gorski, Michael J. Schmidt Tags: Visual Diagnosis in Emergency Medicine Source Type: research

A Non-Epileptiform Event in the Course of rTMS: A Case for Close Physician Monitoring
We present the following case to demonstrate the importance of having physician supervision of patients undergoing repetitive transcranial magnetic stimulation (rTMS) treatments. The patient was a married 60-year-old male with a diagnosis of Major Depressive Disorder and Generalized Anxiety Disorder who had continuous symptoms of depression since the early 1980s despite receiving at least 7 adequate antidepressant treatments. The patient had several comorbid medical conditions. The patient did not have any previous history of seizure, stroke, an abnormal EEG, head injury, neurosurgical procedure, implanted devices, frequen...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 29, 2013 Category: Neurology Authors: F. Andrew Kozel, Paul E. Croarkin, Kimberly S. Mapes Tags: Letters to the Editor Source Type: research

Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: Results by Sex Clinical Trial - ALLHAT
To determine whether an angiotensin-converting enzyme inhibitor (lisinopril) or calcium channel blocker (amlodipine) is superior to a diuretic (chlorthalidone) in reducing cardiovascular disease incidence in sex subgroups, we carried out a prespecified subgroup analysis of 15 638 women and 17 719 men in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Total follow-up (active treatment + passive surveillance using national administrative databases to ascertain deaths and hospitalizations) was 8 to 13 years. The primary outcome was fatal coronary heart disease or nonfatal myocardial i...
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Oparil, S., Davis, B. R., Cushman, W. C., Ford, C. E., Furberg, C. D., Habib, G. B., Haywood, L. J., Margolis, K., Probstfield, J. L., Whelton, P. K., Wright, J. T., for the ALLHAT Collaborative Research Group Tags: Primary prevention, Secondary prevention, Clinical Studies Clinical Trial - ALLHAT Source Type: research

Elderly female with CHF complains of abdominal pain, nausea and vomiting, dizziness, and confusion for 5 days. What is the cause?
Author: V. Dimov, M.D.Reviewer: S. Randhawa, M.D.A 96-year-old African American female (AAF) was admitted from a nursing home with complaints of abdominal pain, nausea and vomiting (N/V), dizziness, confusion and double vision for 5 days. She was discharged from the hospital just 4 days ago. Digoxin was started during that previous hospitalization for control of tachycardia in atrial fibrillation. One day prior to discharge, digoxin level was 1.8 mg/mL and digoxin dose was decreased to 125 mcg PO Q 48 hr.Past medical history (PMH)Hypertension, atrial fibrillation, coronary artery disease, stroke, congestive heart failure.M...
Source: Clinical Cases and Images - August 2, 2009 Category: General Medicine Tags: Cardiology Intensive Care Toxicology Source Type: news