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Total 76 results found since Jan 2013.

Overdose Receiving Centers - An Idea Whose Time Has Come?
Authors: Hern HG, Goldstein D, Tzvieli O, Mercer M, Sporer K, Herring AA Abstract Drug overdose deaths have been the leading cause of accidental death in the United States with two thirds involving opioids. Strong evidence supports the efficacy of medications for addiction treatment such as buprenorphine and harm reduction strategies such as naloxone distribution. While emergency medical service (EMS) systems have defined specialty centers for the treatment of many significant life threatening disease (trauma, stroke, myocardial infarction) implementation of opioid use disorder systems of care that integrate EMS ar...
Source: Prehospital Emergency Care - January 30, 2021 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Comparison of static and dynamic cerebral autoregulation under anesthesia influence in a controlled animal model
by Alexander Ruesch, Deepshikha Acharya, Samantha Schmitt, Jason Yang, Matthew A. Smith, Jana M. Kainerstorfer The brain’s ability to maintain cerebral blood flow approximately constant despite cerebral perfusion pressure changes is known as cerebral autoregulation (CA) and is governed by vasoconstriction and vasodilation. Cerebral perfusion pressure is defined as the pressure gradient between arterial b lood pressure and intracranial pressure. Measuring CA is a challenging task and has created a variety of evaluation methods, which are often categorized as static and dynamic CA assessments. Because CA is quantified as ...
Source: PLoS One - January 8, 2021 Category: Biomedical Science Authors: Alexander Ruesch Source Type: research

Observation of hemodynamic parameters using a non-invasive cardiac output monitor system to identify predictive indicators for post-spinal anesthesia hypotension in parturients undergoing cesarean section.
In conclusion, the baseline CI obtained via the bioreactance-based NICOM™ system may serve as a predictor of post-spinal anesthesia hypotension in parturients regardless of patient position. PMID: 33093906 [PubMed]
Source: Experimental and Therapeutic Medicine - October 24, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report
Rationale: Paroxysmal autonomic instability with dystonia (PAID) is an underdiagnosed syndrome that describes a collection of symptoms following diverse cerebral insults, such as traumatic brain injury, hydrocephalus, hemorrhagic stroke, or brain anoxia. It is manifested by systemic high blood pressure, hyperthermia, tachycardia, tachypnea, diaphoresis, intermittent agitation, and certain forms of dystonia. Patient concerns: A semi-comatose 46-year-old man was transferred from the regional rehabilitation hospital with various complaints involving fluctuating vital signs, including uncontrolled hyperthermia, hypertensi...
Source: Medicine - October 2, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure.
Conclusion These findings indicate that locomotor muscle group III/IV afferent feedback in patients with HFrEF leads to increased systemic vascular resistance, which constrains stroke volume, cardiac output, and O2 delivery thereby impairing V̇O2 peak and thus exercise capacity. These findings have important clinical implications as V̇O2 peak is highly predictive of morbidity and mortality in HF. This article is protected by copyright. All rights reserved. PMID: 32886795 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - September 3, 2020 Category: Physiology Authors: Smith JR, Joyner MJ, Curry TB, Borlaug BA, Keller-Ross ML, Van Iterson EH, Olson TP Tags: J Physiol Source Type: research

The Difficulty Of Counting the COVID-19 Pandemic ’s Full Death Toll
Sara Wittner had seemingly gotten her life back under control. After a December relapse in her battle with drug addiction, the 32-year-old completed a 30-day detox program and started taking a monthly injection to block her cravings for opioids. She was engaged to be married, working for a local health advocacy group in Colorado, and counseling others about drug addiction. Then the COVID-19 pandemic hit. The virus knocked down all the supports she had carefully built around her: no more in-person Narcotics Anonymous meetings, no talks over coffee with trusted friends or her addiction recovery sponsor. As the virus stressed...
Source: TIME: Health - June 22, 2020 Category: Consumer Health News Authors: Markian Hawryluk / Kaiser Health News Tags: Uncategorized COVID-19 Source Type: news

For the First Time in Four Years, the U.S. Life Expectancy Rose a Little
(NEW YORK) — Life expectancy in the United States is up for the first time in four years. The increase is small — just a month — but marks at least a temporary halt to a downward trend. The rise is due to lower death rates for cancer and drug overdoses. “Let’s just hope it continues,” said Robert Anderson, who oversees the report released Thursday by the Centers for Disease Control and Prevention. The latest calculation is for 2018 and factors in current death trends and other issues. On average, an infant born that year is expected to live about 78 years and 8 months, the CDC said. For...
Source: TIME: Health - January 30, 2020 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized health onetime overnight Source Type: news

Levosimendan for patients with heart failure undergoing major oncological surgery: A randomised blinded pilot study
Conclusion: In patients with low EF <35% and CHF, administration of levosimendan for 24 hours before major abdominal oncologic surgeries may reduce the risk of hypotension and decompensated heart failure and may improve cardiac function.
Source: Indian Journal of Anaesthesia - December 10, 2019 Category: Anesthesiology Authors: Ehab H Shaker Khaled Hussein Ehab M Reyad Source Type: research

A Serious Diagnosis Lacking Common Symptoms
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; & AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regi...
Source: The Case Files - May 28, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Intraoperative Anesthesiology Management and Patient Outcomes for Surgical Revascularization for Moyamoya Disease: A Review and Clinical Experience
Conclusion Increasing use of remifentanil in MMD cases could be attributed to its ability to provide more stable hemodynamics during induction, maintenance, and emergence of anesthesia when compared with fentanyl. Lower systolic pressures, diastolic pressures, and heart rates were reported in patients receiving remifentanil over fentanyl. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - February 28, 2019 Category: Neurosurgery Authors: Williams, George W. Jones, William S. Chaudhry, Rabail Cai, Chunyan Pednekar, Greesha S. Long, Alia C. Chouhan, Shilpa Artime, Carlos Wegner, Robert C. Grewal, Navneet K. Patterson, Velvet M. Contreras, Daniel A. Ferrario, Lara Tags: Original Article Source Type: research

US Life Expectency Drops; Drug Overdoses & Suicide To Blame
By Susan Scutti, CNN (CNN) — Life expectancy in the United States declined from 2016 to 2017, yet the 10 leading causes of death remained the same, according to three government reports released Thursday. Increasing deaths due to drug overdoses and suicides explain this slight downtick in life expectancy, the US Centers for Disease Control says. Overdose deaths reached a new high in 2017, topping 70,000, while the suicide rate increased by 3.7%, the CDC’s National Center for Health Statistics reports. Dr. Robert Redfield, CDC director, called the trend tragic and troubling. “Life expectancy gives us a s...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 29, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Source Type: news

U.S. Life Expectancy Dropped for the Third Year in a Row. Drugs and Suicide Are Partly to Blame
U.S. life expectancy dropped in 2017 for the third consecutive year, as deaths by suicide and drug overdose continue to claim more American lives. The average American could expect to live to 78.6 years old in 2017, down from 78.7 in 2016, according to data released Thursday by the Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS). That decline may be modest, but it marks the third year in a row that life expectancy at birth has fallen — a noteworthy phenomenon, since the previous multiyear drop recorded by the NCHS was in the early 1960s. The modern trend seems to be pr...
Source: TIME: Health - November 29, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime public health Source Type: news

The association between clopidogrel and 2-oxo-clopidogrel plasma levels and the long-term clinical outcome after acute myocardial infarction 
.
CONCLUSION: In patients with acute MI treated with PCI, lower dose-adjusted clopidogrel and dose-adjusted 2-oxo-clopidogrel plasma concentrations were associated with an increased risk of ischemic events.
. PMID: 30431425 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - November 17, 2018 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40  months clinical outcome after primary PCI
Conclusion Clopidogrel dose-adjusted plasma concentration in STEMI patients, as well as multivessel coronary artery disease, showed significance in predicting an unfavorable composite clinical outcome after 40-month follow-up.
Source: International Journal of Clinical Pharmacy - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

Looking Past Dementia Reveals Hidden Life Threats
Conclusion Acute delirium is commonly underdiagnosed, and can be masked by chronic alterations in cognition and mentation. Delirium has many causes, and can be assessed using the acronym DELIRIUM. The most common presentations suggesting delirium over dementia are short-term memory loss, rapid fluctuation in condition, acute alteration, and a condition present that may be responsible for delirium. Management includes searching for causes of acute alteration in mental status, negating environmental factors of delirium, and—only when necessary—reducing the patient’s threat to themselves or providers by using butyrophen...
Source: JEMS Special Topics - August 13, 2018 Category: Emergency Medicine Authors: Joseph K. Mesches, NRP, FP-C Tags: Exclusive Articles Patient Care Source Type: news