Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure.

Conclusion These findings indicate that locomotor muscle group III/IV afferent feedback in patients with HFrEF leads to increased systemic vascular resistance, which constrains stroke volume, cardiac output, and O2 delivery thereby impairing V̇O2 peak and thus exercise capacity. These findings have important clinical implications as V̇O2 peak is highly predictive of morbidity and mortality in HF. This article is protected by copyright. All rights reserved. PMID: 32886795 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research