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Total 171 results found since Jan 2013.

Understanding the impact of psychosocial working conditions on workers ’ health: we have come a long way, but are we there yet?
This issue of the journal includes a meta-review, ie, a systematic review of systematic reviews, summarizing the published evidence on the associations between exposure to adverse psychosocial working conditions and risk of developing diseases or disorders during the past 20 years (1). Although the authors allowed inclusion of reviews reporting results from cross-sectional studies, the majority of the included reviews were restricted to prospective cohort studies – the gold standard method in psychosocial occupational epidemiology. We commend the authors for their succinct summary of the current knowledge on the topic, e...
Source: Scandinavian Journal of Work, Environment and Health - September 3, 2021 Category: Occupational Health Tags: Editorial Source Type: research

Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage. Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored ...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news

Unlocking Cardiovascular Health
In 2011, the Centers for Disease Control and Prevention published the “Ten Great Public Health Achievements—United States, 2001–2010.”1 Cardiovascular disease (CVD) prevention made the list. Indeed, the combination of reductions in major cardiovascular risk factors, such as elevated blood pressure, high cholesterol, and smoking, combined with improvements in t reatments led to a substantial reduction in the prevalence of stroke and coronary heart disease over the past decades. Unfortunately, heart disease and stroke continue to be responsible for more deaths than cancer and lung diseases combined.
Source: Primary Care: Clinics in Office Practice - August 30, 2023 Category: Primary Care Authors: Anthony J. Viera Tags: Preface Source Type: research

CDC National Health Report: Leading Causes of Morbidity and Mortality and Associated Behavioral Risk and Protective Factors-United States, 2005-2013.
This report reviews population health in the United States and provides an assessment of recent progress in meeting high-priority health objectives. The health status indicators described in this report were selected because of their direct relation to the leading causes of death and other substantial sources of morbidity and mortality and should be the focus of prevention efforts. REPORTING PERIOD COVERED: Data are reported starting in 2005 (or the earliest available year since 2005) through the current data year. Because data sources and specific indicators vary regarding when data are available, the most recent yea...
Source: MMWR Surveill Summ - October 31, 2014 Category: Epidemiology Authors: Johnson NB, Hayes LD, Brown K, Hoo EC, Ethier KA Tags: MMWR Surveill Summ Source Type: research

Abstract 243: A Novel Cost Effectiveness Model of Eicosapentaenoic Acid (EPA) for Secondary Prevention in the United States Session Title: Poster Session II
Conclusions: This novel model suggests that combining EPA with statin therapy for secondary prevention of cardiovascular disease in the United States may be cost-saving and appears to be a more compelling intervention than statin monotherapy. The framework of this model provides a starting point for development of microsimulation models as more data become available.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Schmier, J. K., Hulme-Lowe, C., Nelson, J. R., Chowdhury, S., Everett, P. B., Philip, S. Tags: Session Title: Poster Session II Source Type: research

Association of Long-Term Exposure to Transportation Noise and Traffic-Related Air Pollution with the Incidence of Diabetes: A Prospective Cohort Study
Conclusion: We found a positive association between residential transportation noise and diabetes, adding to the growing body of evidence that noise pollution exposure may be independently linked to metabolic health and should be considered when developing public health interventions. https://doi.org/10.1289/EHP1279 Received: 26 October 2016 Revised: 07 May 2017 Accepted: 09 May 2017 Published: 31 August 2017 Address correspondence to C. Clark, Ove Arup and Partners, Acoustics, 13 Fitzroy Street, London, W1T 4BQ, UK. Telephone: +44 207755 4702. Email: Charlotte.Clark@arup.com The authors declare they have no actual o...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Cardiovascular health disparities between whites and minorities narrow, study shows
The nation ’s overall cardiovascular health worsened from 1988 to 2014, with disparities among racial and ethnic groups dropping slightly. But the reduction in disparities was due to worsening health among whites — not improvements among African-Americans and Mexican-Americans, a new UCLA-led study suggest s.“The reason for the reduction in disparities was unexpected,” said lead author Dr. Arleen Brown, professor of medicine in the division of general internal medicine at the David Geffen School of Medicine at UCLA and Olive View Medical Center. “Whites were the only group we studied where the pre valence of opti...
Source: UCLA Newsroom: Health Sciences - March 20, 2018 Category: Universities & Medical Training Source Type: news

Trends in Racial/Ethnic and Nativity Disparities in Cardiovascular Health Among Adults Without Prevalent Cardiovascular Disease in the United States, 1988 to 2014.
Conclusion: Cardiovascular health has declined in the United States, racial/ethnic and nativity disparities persist, and decreased disparities seem to be due to worsening cardiovascular health among whites rather than gains among African Americans and Mexican Americans. Multifaceted interventions are needed to address declining population health and persistent health disparities. Primary Funding Source: National Institute of Neurological Disorders and Stroke and National Center for Advancing Translational Science of the National Institutes of Health. PMID: 29554692 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Brown AF, Liang LJ, Vassar SD, Escarce JJ, Merkin SS, Cheng E, Richards A, Seeman T, Longstreth WT Tags: Ann Intern Med Source Type: research

Prescription of Statins to Women Poses New Clinical Challenges
In women and men, cardiovascular disease is and will remain the leading avoidable cause of premature death in the United States and is rapidly becoming so worldwide. (1) While many women fear breast cancer more than cardiovascular disease, 1 in 8 will develop and 1 in 25 will die from this disease whereas over 1 in 3 will die from coronary heart disease and 1 in 6 from stroke. (2)
Source: The American Journal of Medicine - April 18, 2018 Category: General Medicine Authors: Madeline Pung, Janet Robishaw, Marc A. Pfeffer, Charles H. Hennekens Tags: Commentary Source Type: research

Usefulness of alirocumab and evolocumab for the treatment of patients with diabetic dyslipidemia.
Abstract In 2015, the US Food and Drug Administration (FDA) approved the anti-proprotein convertase subtilsin/kexin type 9 (PCSK9) monoclonal antibodies, alirocumab and evolocumab, to treat patients with hypercholesterolemia and mixed dyslipidemia. Since then, considerable attention has been paid to the use of these monoclonal antibodies for the treatment of diabetic dyslipidemia with a goal of reducing the risk for cardiovascular disease. Recently, consensus statements on the clinical use of PCSK9 inhibitors in patients with type 2 diabetes mellitus, who are unable to achieve the goal of low-density lipoprotein c...
Source: Baylor University Medical Center Proceedings - April 1, 2018 Category: Universities & Medical Training Authors: Zhang J, Tecson KM, Rocha NA, McCullough PA Tags: Proc (Bayl Univ Med Cent) Source Type: research

Surveillance for Certain Health Behaviors and Conditions Among States and Selected Local Areas - Behavioral Risk Factor Surveillance System, United States, 2015.
This report presents results for all 50 states, the District of Columbia, the Commonwealth of Puerto Rico (Puerto Rico), and Guam and for 130 metropolitan and micropolitan statistical areas (MMSAs) (N = 441,456 respondents) for 2015. RESULTS: The age-adjusted prevalence estimates of health-risk behaviors, self-reported chronic health conditions, access to and use of health care, and use of preventive health services varied substantially by state, territory, and MMSA in 2015. Results are summarized for selected BRFSS measures. Each set of proportions refers to the median (range) of age-adjusted prevalence estimates for...
Source: MMWR Surveill Summ - June 29, 2018 Category: Epidemiology Authors: Pickens CM, Pierannunzi C, Garvin W, Town M Tags: MMWR Surveill Summ Source Type: research

New Cholesterol Guidelines Focus on Personalized Approach
SATURDAY, Nov. 10, 2018 -- A lifelong approach to lowering cholesterol, starting in some kids as young as 2, is the United States ' best bet to lower everyone ' s risk of heart attack and stroke, according to updated guidelines released Saturday by the...
Source: Drugs.com - Daily MedNews - November 10, 2018 Category: General Medicine Source Type: news

Cost-Effectiveness of Alirocumab: A Just-in-Time Analysis Based on the ODYSSEY Outcomes Trial.
Conclusion: The price of alirocumab would have to be reduced considerably to be cost-effective. Because substantial reductions already have occurred, we believe that timely, independent cost-effectiveness analyses can inform clinical and policy discussions of new drugs as they enter the market. Primary Funding Source: University of California, San Francisco, and Institute for Clinical and Economic Review. PMID: 30597485 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - January 1, 2019 Category: Internal Medicine Authors: Kazi DS, Penko J, Coxson PG, Guzman D, Wei PC, Bibbins-Domingo K Tags: Ann Intern Med Source Type: research