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Total 146 results found since Jan 2013.

Premature acute coronary syndrome: understanding the early onset
Introduction Acute coronary syndrome (ACS) is less frequent in young adults, but it has become a significant health problem, associated with the increasing prevalence of modifiable risk factors. Objectives To characterize patients admitted with premature ACS, comparing with those with nonpremature ACS. Methods We performed a retrospective study encompassing patients of the Portuguese Registry (ProACS), comparing two groups: one composed of men less than 55 and women less than 65 years old; and other with men ≥55 and women ≥65 years old at the ACS admission. The primary endpoint was the composite o...
Source: Coronary Artery Disease - August 1, 2022 Category: Cardiology Tags: Original Research Source Type: research

Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial
Lancet Respir Med. 2022 Oct 10:S2213-2600(22)00298-3. doi: 10.1016/S2213-2600(22)00298-3. Online ahead of print.ABSTRACTBACKGROUND: COVID-19 disease is accompanied by a dysregulated immune response and hypercoagulability. The Anti-Coronavirus Therapies (ACT) inpatient trial aimed to evaluate anti-inflammatory therapy with colchicine and antithrombotic therapy with the combination of rivaroxaban and aspirin for prevention of disease progression in patients hospitalised with COVID-19.METHODS: The ACT inpatient, open-label, 2 × 2 factorial, randomised, controlled trial was done at 62 clinical centres in 11 countries. Patient...
Source: Respiratory Care - October 13, 2022 Category: Respiratory Medicine Authors: John W Eikelboom Sanjit S Jolly Emilie P Belley-Cote Richard P Whitlock Sumathy Rangarajan Lizhen Xu Laura Heenan Shrikant I Bangdiwala Maria Luz Diaz Rafael Diaz Afzalhussein Yusufali Sanjib Kumar Sharma Wadea M Tarhuni Mohamed Hassany Alvaro Avezum Will Source Type: research

COPD and COVID-19: a dangerous association?
Conclusion: COPDs patients are mostly ederly men with comorbidities. The most effective treatment for them was stabilization of comorbidities and conventional oxygen and for the most severe Helmet-CPAP and NIV. In addition, COPD patients had no higher risk of mortality from COVID-19 than individuals without a pre-existing diagnosis of COPD.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mendez Gonzalez, L., Ferreira, J., Caneiras, C. Tags: 05.02 - Monitoring airway disease Source Type: research

Late-onset fabry disease due to the p.Phe113Leu variant: the first italian cluster of five families
ConclusionThis study demonstrates that a cluster of subjects with p.Phe113Leu pathogenic variant is also present in Southern Italy. Disease manifestations are frequent in both sexes and may occur early in life. Cardiac involvement represents the core manifestation, but neurological and renal involvement is also frequent, suggesting that extra-cardiac complications deserve clinical attention.
Source: Metabolic Brain Disease - April 25, 2023 Category: Neurology Source Type: research

Assessment of cardiovascular risk factors in patients with idiopathic inflammatory myopathies: a systematic review
AbstractWe performed a systematic review of cardiovascular risk factors in idiopathic inflammatory myopathies (IIMs) and their cardiovascular outcomes, including acute coronary syndrome and stroke. A qualitative systematic review was conducted from January 1956 to December 2022 according to the PRISMA protocol using three electronic databases: PubMed, Web of Science, and Scopus. The studies were analyzed based on the following eligibility criteria: at least one combination of the terms described in the search strategy appeared in the title, written in English, Portuguese, or Spanish, and addressed risk factors for cardio...
Source: Clinical Rheumatology - May 16, 2023 Category: Rheumatology Source Type: research

Interpersonal Values of Patients Participating in Phase II –III Clinical Trials: Implications for Clinical Trial Representativeness
ConclusionsThis novel analysis of the interpersonal values of patients that participate in Phase II and III clinical trials revealed that the patients ’ interpersonal values largely differed from those of the Portuguese normative population. Better understanding the implications of these findings for clinical trial representativeness and outcomes is of crucial importance.
Source: Pharmaceutical Medicine - May 30, 2023 Category: Drugs & Pharmacology Source Type: research

Brazilian Portuguese Adaptation and Validation of the Language Screening Test for Poststroke Patients
CONCLUSION: The Brazilian Portuguese version of the LAST is a valid, simple, easy, and rapid test to screen poststroke aphasia in hospital settings.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.23548911.PMID:37410632 | DOI:10.1044/2023_JSLHR-22-00611
Source: Journal of speech, language, and hearing research : JSLHR - July 6, 2023 Category: Speech-Language Pathology Authors: Renata de Lima Ramos Mariana M Bahia Constance Flamand-Roze Regina Yu Shon Chun Source Type: research

More Europeans Died Because of Heat in 2022 Than Any Year in Recorded History
As the Earth continues to warm, the rising temperatures are contributing to a number of health conditions that are in turn driving up mortality. And for the first time, scientists have figured out a more detailed way to estimate how many deaths can be attributed to heat. In a paper published in Nature Medicine, researchers in Spain and France calculated that more than 61,000 deaths in Europe could be blamed on the heat during the summer of 2022, the hottest summer on record for the continent. (At least until the readings from 2023 are analyzed later this year.) [time-brightcove not-tgx=”true”] “We are pro...
Source: TIME: Health - July 10, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized climate change embargoed study healthscienceclimate Source Type: news