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Association of underlying untreated cardiovascular risk factors with mortality and functional outcome in ischaemic stroke patients
Stroke is the third leading cause of death after ischaemic heart disease (IHD) and pneumonia in Malaysia.1 Aziz et al. reported that Malaysia's prevalence of ischaemic stroke had increased from 42.8 to 118.7 in 100,000 from 2010 to 2014. The report showed that 8-11% of ischaemic stroke patients died within 30 days while 56-61% survived with significant disability in Malaysia.2 Our previous study showed that patients with ischaemic stroke in Malaysia were younger, but the mortality rate was higher than in other countries.
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2023 Category: Neurology Authors: Teck Long King, Lee Len Tiong, Zariah Abdul  Aziz, Wan Chung Law Source Type: research

Predictive model of recurrent ischemic stroke: model development from real-world data
ConclusionThe hazard of recurrent IS magnitude differs during different time intervals based on the concomitant risk factors and secondary prevention.
Source: Frontiers in Neurology - April 28, 2023 Category: Neurology Source Type: research

Stroke thrombolysis in a middle-income country: A case study exploring the determinants of its implementation
ConclusionsDespite the ongoing challenges, the success in implementing intravenous stroke thrombolysis as standard of care was attributed to the cohesiveness of team members and having facilitative work processes. For countries of similar settings, plans to improve the uptake of intravenous stroke thrombolysis should consider the inclusion of interventions targeting on these modifiable factors.
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research

Experiences and needs of the caregivers of stroke survivors in Malaysia —A phenomenological exploration
ConclusionThe role of informal caregivers becomes critical for continuum of stroke care. As caregivers take up the roles and responsibilities of those who contribute to stroke rehabilitation single-handedly soon after hospital discharge. Results of this study highlights the needs for providing systematic support to caregivers for engaging them in effective stroke care, particularly in the community. Stroke service providers, policy makers and program planners must be sensitized to empower caregivers of stroke survivors in effectively supporting stroke survivor in their family on the road of recovery.
Source: Frontiers in Neurology - September 23, 2022 Category: Neurology Source Type: research

Stroke Burden in Malaysia
Malaysia is located in the heart of South East Asia with two land masses, Peninsular Malaysia and East Malaysia which are separated by the South China Sea. Stroke or cerebrovascular disease is Malaysia ’s third leading cause of death. There were 47, 911 incident cases, 19,928 deaths, 443,995 prevalent cases, and 512,726 DALYs lost due to stroke in 2019. Successive national health and morbidity surveys from 2006 demonstrated a continuous rise in the prevalence of risk factor such as diabetes, hyp erlipidaemia and obesity. These risk factors are implicated in an increase in stroke incidence in those under 65 years of age, ...
Source: Cerebrovascular Diseases Extra - March 24, 2022 Category: Neurology Source Type: research

SLC17A3 rs9379800 and Ischemic Stroke Susceptibility at the Northern Region of Malaysia
The relationships of Paired Like Homeodomain 2 (PITX2), Ninjurin 2 (NINJ2), TWIST-Related Protein 1 (TWIST1), Ras Interacting Protein 1 (Rasip1), Solute Carrier Family 17 Member 3 (SLC17A3), Methylmalonyl Co-A Mutase (MUT) and Fer3 Like BHLH Transcription Factor (FERD3L) polymorphisms and gene expression with ischemic stroke have yet to be determined in Malaysia. Hence, this study aimed to explore the associations of single nucleotide polymorphisms (SNPs) and gene expression with ischemic stroke risk among population who resided at the Northern region of Malaysia.
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2021 Category: Neurology Authors: Shu Chai Ching, Lim Jing Wen, Nor Ismaliza Mohd Ismail, Irene Looi, Cheah Wee Kooi, Long Soo Peng, Lee Soon Mui, Jayashamani Tamibmaniam, Prema Muninathan, Ong Beng Hooi, Siti Maisarah Md Ali, Muhammad Radzi Abu Hassan, Mohd Saberi Mohamad, Lyn R Griffith Source Type: research

Challenges for Diagnostic Clarity for Post-stroke Cognitive Impairment and Behavioural Issues in Middle-Income Countries: Case Studies From Malaysia
Following stroke, individuals require ongoing screening, diagnosis and monitoring for cognitive impairment. Services and policies around these vary widely between settings, and reports from many countries highlight persistent under-diagnosis of cognitive impairment in the months and years after stroke. Missed and delayed diagnosis of post-stroke cognitive impairment, including dementia, are important factors in shaping the experiences of people so affected and their family members, especially in low- and middle-income countries. Drawing upon ethnographic research conducted in Malaysia, this article draws upon three case st...
Source: Frontiers in Neurology - June 2, 2021 Category: Neurology Source Type: research

A hospital-based study on ischaemic stroke characteristics, management, and outcomes in Sarawak: Where do we stand?
Located on the Borneo Island, Sarawak is the largest state of Malaysia and has a population distinctive from Peninsular Malaysia. The ischaemic stroke data in Sarawak had not been reported despite the growing number of patients annually. We aimed to investigate patient characteristics, management, and outcomes of ischaemic stroke in Sarawak and benchmark the results with national and international published data.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Teck Long King, Lee Len Tiong, Zurainah Kaman, Win Moe Zaw, Zariah Abdul Aziz, Law Wan Chung Source Type: research

Predictors of Recurrent Ischemic Stroke in Obese Patients With Type 2 Diabetes Mellitus: A Population-based Study
Each year, approximately 0.8 million people are estimated to experience a new or recurrent stroke, according to the 2019 report of the American Heart Association.1 In Malaysia, stroke is the third leading cause of death after ischemic heart disease (IHD) and pneumonia.2 Both obesity and diabetes are considered as the established independent risk factors for ischemic stroke.3 Type 2 diabetes mellitus (T2DM) was also found to be associated with an increase in all-cause as well as cardiovascular mortality following the stroke,4,5 and in a meta-analysis of 18 studies, patients with diabetes had a higher stroke recurrence as co...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Orwa Albitar, Sabariah Noor Harun, Nur Ezzati Abidin, Balamurugan Tangiisuran, Hadzliana Zainal, Irene Looi, Khairul Azmi Ibrahim, Norsima Nazifah Sidek, Keat Wei Loo, Keng Yee Lee, Zariah Abdul Aziz, Siti Maisharah Sheikh Ghadzi Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Trends in stroke outcomes at hospital discharge in first-ever stroke patients: Observations from the Malaysia National Stroke Registry (2009 –2017)
Stroke outcomes could be a quality indicator across the continuum of care and inform stroke management policymaking. However, this topic has rarely to date been studied directly.
Source: Journal of the Neurological Sciences - April 9, 2019 Category: Neurology Authors: Xin Wee Chen, Mohd Nazri Shafei, Zariah Abdul Aziz, Norsima Nazifah Sidek, Kamarul Imran Musa Source Type: research

Prescription of secondary preventive drugs after ischemic stroke: results from the Malaysian National Stroke Registry
This study assessed the prescription of secondary preventive drugs among ischemic stroke patients upon hospital dis...
Source: BMC Neurology - November 23, 2017 Category: Neurology Authors: Wen Yea Hwong, Zariah Abdul Aziz, Norsima Nazifah Sidek, Michiel L. Bots, Sharmini Selvarajah, L. Jaap Kappelle, Sheamini Sivasampu and Ilonca Vaartjes Tags: Research article Source Type: research

Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia.
DISCUSSION: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male. PMID: 27142804 [PubMed - as supplied by publisher]
Source: Neurological Research - May 6, 2016 Category: Neurology Tags: Neurol Res Source Type: research