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Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

311 Older Adults Awareness and Response to Stroke in Ireland.
ConclusionAwareness of stroke symptoms does not necessarily influence response to stroke in older adults. Future stroke awareness campaigns should consider FAST2 which speaks to treatment (thrombolysis or thrombectomy) as well as time.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

Inclusion of stroke patients in expanded cardiac rehabilitation services: a cross-national qualitative study with cardiac and stroke rehabilitation professionals.
CONCLUSIONS: Hybrid cardiac rehabilitation programmes could be tailored to deliver stroke-specific education, exercises and multidisciplinary expertise. Post-stroke cognitive impairment was identified as a key barrier to participation in cardiac rehabilitation. A cognitive rehabilitation intervention could potentially be delivered as part of cardiac rehabilitation, to address the cognitive needs of stroke and cardiac patients. Implications for rehabilitation The cardiac rehabilitation model has the potential to be expanded to include mild stroke patients given the commonality of secondary prevention needs. Up to half of st...
Source: Disability and Rehabilitation - February 2, 2021 Category: Rehabilitation Authors: Jeffares I, Merriman NA, Doyle F, Horgan F, Hickey A Tags: Disabil Rehabil Source Type: research

Increased Risk of Stroke Linked to Stress at Home, Work
Experiencing multiple stressful events or chronic stress at home or at work over the course of a year raises the risk of several types of stroke, astudy published today inJAMA Network Open has found. However, the study also suggests that having a greater sense of control over the situations and experiences that affect one ’s life—a greater locus of control—may help counter the impact of stress on stroke risk.Catriona Reddin, M.B., of the University of Galway in Ireland and colleagues analyzed data from 26,812 participants in the INTERSTROKE study, an international case-control study of risk factors for stroke. Among ...
Source: Psychiatr News - December 9, 2022 Category: Psychiatry Tags: home stress INTERSTROKE study JAMA Network Open locus of control work stress Source Type: research

Suboptimal lipid management before and after ischaemic stroke and TIA —the North Dublin Population Stroke Study
ConclusionsIn this population-based study, LLT recommended by international guidelines was under-used, before and after index stroke/TIA. Strategies to improve adherence are needed.
Source: Irish Journal of Medical Science - January 24, 2018 Category: General Medicine Source Type: research

Association of RAGE with acute ischemic stroke prognosis in type 2 diabetes
ConclusionAcute ischemic stroke is associated with elevated serum RAGE level, which, at admission, is an independent predictor of poor outcome for stroke in type 2 diabetes.
Source: Irish Journal of Medical Science - September 27, 2020 Category: General Medicine Source Type: research

Thrombolysis for stroke in Ireland: increasing access and maintaining safety in a challenging environment
ConclusionStroke thrombolysis is being effectively and safely provided in acute stroke services in Ireland despite regular involvement of non-specialist staff. There is still potential to improve thrombolysis rate.
Source: Irish Journal of Medical Science - July 17, 2017 Category: General Medicine Source Type: research

24 Stroke Risk Factors, Aetiology, and Outcomes in a Multi-ethnic Irish Stroke Population
ConclusionOur study demonstrates that NI stroke patients have a different risk factor and stroke sub-type profile compared to Irish patients.  NI patients are more likely to be young, hypertensive, male, and have higher rates of ICH. Cultural and linguistic barriers may adversely influence health seeking behaviour in this group. These findings underscore the need to identify the root causes of these ethnic differences so targeted prima ry prevention campaigns can be established.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

IJERPH, Vol. 17, Pages 7203: The Prevalence of Cognitive Impairment on Admission to Nursing Home among Residents with and without Stroke: A Cross –Sectional Survey of Nursing Homes in Ireland
IJERPH, Vol. 17, Pages 7203: The Prevalence of Cognitive Impairment on Admission to Nursing Home among Residents with and without Stroke: A Cross–Sectional Survey of Nursing Homes in Ireland International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17197203 Authors: Nora-Ann Donnelly Eithne Sexton Niamh A. Merriman Kathleen E. Bennett David J Williams Frances Horgan Paddy Gillespie Anne Hickey Maev-Ann Wren Post–stroke cognitive impairment (PSCI) is a common consequence of stroke. Epidemiological evidence indicates that, with an ageing population, stroke an...
Source: International Journal of Environmental Research and Public Health - September 30, 2020 Category: Environmental Health Authors: Nora-Ann Donnelly Eithne Sexton Niamh A. Merriman Kathleen E. Bennett David J Williams Frances Horgan Paddy Gillespie Anne Hickey Maev-Ann Wren Tags: Article Source Type: research

IJERPH, Vol. 19, Pages 13848: Life and Leisure Activities following Stroke or Transient Ischaemic Attack (TIA): An Observational, Multi-Centre, 6-Month Follow-Up Study
Conclusions: Some groups experienced a greater reduction in activities than others—notably older participants, female participants, and those living in a low socioeconomic area. Registration: researchregistry4607. Strengths and limitations of this study: 1. This is the largest-ever study to survey life and leisure activity engagement following stroke/TIA. 2. Survey responses were self-reported retrospectively and, therefore, may have been misreported, or misremembered. 3. Despite the large cohort, there were few participants, and so respondents, from ethnic minority groups.
Source: International Journal of Environmental Research and Public Health - October 25, 2022 Category: Environmental Health Authors: Matthew J. Reeves Clare Thetford Naoimh McMahon Denise Forshaw Chris Brown Miland Joshi Caroline Watkins Tags: Article Source Type: research

In light of recently published clinical trials and their implication for clinical practice, does a large catchment area acute hospital require 24  hour CT neck and head angiography and/or neuro-interventional services in the setting of acute ischaemic stroke?
ConclusionUHL should provide routine CT angiography to all patients presenting with acute ischaemic stroke in line with current guidelines. The need for provision of neuro-interventional services on-site proved more difficult to assess and requires further analysis.
Source: Irish Journal of Medical Science - August 15, 2017 Category: General Medicine Source Type: research

Rehabilitation of patients after transient ischaemic attack or minor stroke: pilot feasibility randomised trial of a home-based prevention programme.
CONCLUSION: Findings indicate that implementation of this novel cardiac rehabilitation programme, and of a trial to evaluate its effectiveness, is feasible, with potential for clinically important benefits and improved secondary prevention after TIA or 'minor' stroke. PMID: 31501165 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - September 8, 2019 Category: Primary Care Authors: Heron N, Kee F, Mant J, Cupples ME, Donnelly M Tags: Br J Gen Pract Source Type: research

317 Incidence of Cognitive Impairment after Stroke: a Retrospective Cohort of Rehabilitation Patients.
ConclusionThis study replicates Pendlebury and Rothwell ’s findings that over a third of people suffering from severe strokes will develop cognitive impairment. This is of critical importance to stroke clinicians as it should prompt frank discussions with stroke patients and their families about prognosis, recovery and future planning.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

Stroke Risk Factors, Subtype, and Outcomes in a Multi-Ethnic Stroke Population
Conclusion Our study demonstrates that stroke patients ONIE have a different stroke subtype and demographic profile compared to Irish patients. Patients ONIE are more likely to be young, male with higher rates of ICH.PMID:35279054
Source: Ir Med J - March 13, 2022 Category: General Medicine Authors: J Finnegan S Mello N Cogan S Greene D Ryan R Collins Source Type: research

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