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Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

The incidence rate of diabetes mellitus (type II) and its related risk factors: A 10-year longitudinal study of Yazd Healthy Heart Cohort (YHHC), Iran
ConclusionIn the present study, Age, family history of DM, abdominal obesity, high triglycerides, and high uric acid are the most important risk factors for diabetes.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - February 27, 2019 Category: Endocrinology Source Type: research

Incidence rate of diabetes mellitus (type II) and its related risk factors: A 10-year longitudinal study of Yazd Healthy Heart Cohort (YHHC), Iran
ConclusionIn the present study, Age, family history of DM, abdominal obesity, high triglycerides and high uric acid are the most important risk factors for diabetes.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - February 6, 2019 Category: Endocrinology Source Type: research

Hypoglycemia: Adverse Cardiovascular Outcomes in Non-Critically Ill People with Type 2 Diabetes.
CONCLUSION: Hypoglycemia is a major risk factor for occurrence of the first major cardiovascular event in non-critically ill people with type 2 diabetes initiating insulin therapy. PMID: 26838076 [PubMed - in process]
Source: Archives of Iranian Medicine - February 1, 2016 Category: Middle East Health Authors: Akhavan P, Aghili R, Malek M, Ebrahim Valojerdi A, Khamseh ME Tags: Arch Iran Med Source Type: research