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Specialty: Neuroscience
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Total 250 results found since Jan 2013.

Influence of the rs6736 Polymorphism on Ischemic Stroke Susceptibility in Han Chinese Individuals via the Disruption of miR-7 –1 Binding to the C14orf119 Gene
This study investigates the association between theC14orf119 gene rs6736 polymorphism and ischemic stroke (IS) susceptibility, and explores the influence of the rs6736 polymorphism on the binding between miR-7 –1 and theC14orf119 gene. mRNA expression levels were determined in 45 IS patients and 45 matched controls via real-time quantitative PCR. A total of 774 IS patients and 793 matched controls were recruited from a Han Chinese population for genotyping, performed with the Sequenom MassARRAY iPLEX platform. A dual-luciferase reporter assay was used for the analysis of miRNA –mRNA binding. The results showed that the...
Source: Journal of Molecular Neuroscience - September 11, 2021 Category: Neuroscience Source Type: research

Gender Difference in the Association Between Stroke Knowledge and Health Behavior Before the Onset of Stroke Among Chinese Hypertensive Patients
BACKGROUND: Previous research has shown that men and women have different levels of stroke knowledge and differing health behaviors, which are important factors affecting blood pressure, as hypertension is a key risk factor for stroke occurrence. There has been little research on the effects of sex on the association between these 2 variables before the onset of stroke among Chinese hypertensive patients. METHODS: A cross-sectional study and a convenience sampling method were used. 272 male and 118 female hypertensive stroke patients were recruited. Each patient completed the Stroke Knowledge Questionnaire and the Health B...
Source: Journal of Neuroscience Nursing - July 9, 2021 Category: Neuroscience Tags: Articles Source Type: research

Association of CHUK gene polymorphism and ischemic stroke in the Han Chinese population
Publication date: June 2021Source: Journal of Clinical Neuroscience, Volume 88Author(s): Jingyan Huang, Qiugui Wei, Baoyun Liang, Tingting Shen, Yanli Wu, Ziwen Chen, Junwei Yang, Lian Gu
Source: Journal of Clinical Neuroscience - April 24, 2021 Category: Neuroscience Source Type: research

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis
Neurochem Res. 2021 Apr 11. doi: 10.1007/s11064-021-03285-2. Online ahead of print.ABSTRACTCerebral ischaemia/reperfusion (I/R) injury-induced irreversible brain injury is a major cause of mortality and functional impairment in ageing people. Gastrodin (GAS), derived from the traditional Chinese herbal medicine Tianma, has been reported to inhibit the progression of stroke, but the mechanism whereby GAS modulates the progression of cerebral I/R remains unclear. The middle cerebral artery occlusion method was used as a model of I/R in vivo. Rats were pretreated with GAS by intraperitoneal injection 7 days before I/R surgery...
Source: Neurochemical Research - April 11, 2021 Category: Neuroscience Authors: Heng-Sheng Zhang Bo Ouyang Xiong-Ying Ji Mei-Fang Liu Source Type: research

Association of KATP Gene Polymorphisms with Dyslipidemia and Ischemic Stroke Risks Among Hypertensive Patients in South China
This study investigates the potential association between KATP polymorphisms and hypertension (HTN), dyslipidemia, and consequently ischemic stroke (IS). Nine hundred and fourteen (914) patients genotyped for KATP polymorphisms (rs2285676, rs1799858, rs4148671, rs61928479, and rs141294036) were analyzed. KATP rs141294036 (CC, adjusted OR  = 1.59, 95%CI: 1.17–2.14,P = 0.003) was related to higher HTN risk. Meanwhile, rs2285676 (AA + GA, adjusted OR = 1.53, 95%CI: 1.08–2.19,P = 0.018) was associated with increased triglyceride level (≥ 1.7 mmol/L). rs2285676 (AA + GA, adjusted OR = 1.80, 95% CI: 1.24–...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Slower recovery of outpatient clinics than inpatient services for stroke and other neurological diseases after COVID-19 Pandemic.
CONCLUSIONS: The COVID-19 pandemic caused a significant drop of in-person outpatient visits and inpatient services. Clinic visits recovered slower than inpatient services in stroke and other neurological diseases after the pandemic. PMID: 33058536 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - October 15, 2020 Category: Neuroscience Authors: Zhao J, Wang Y, Fisher M, Liu R Tags: CNS Neurosci Ther Source Type: research

Ethnic differences in characteristics and outcome of acute ischemic stroke in China: A single center experience
Publication date: September 2020Source: Journal of Clinical Neuroscience, Volume 79Author(s): Huiying Huang, Hui Zheng, Daobao Zhang, Nengwei Yu, Jia Hu, Mengqiao Xie, Lingwen Tang, Xiaoxia Li, Shan Zhang, Fuqiang Guo
Source: Journal of Clinical Neuroscience - August 13, 2020 Category: Neuroscience Source Type: research

Confirmation of potential neuroprotective effects of natural bioactive compounds from traditional medicinal herbs in cerebral ischemia treatment.
Abstract Ischemic brain injury is a prevalent disease with high disability and mortality, but no efficient therapeutics for the disease are currently available mainly due to the narrow therapeutic window. The treatment of cerebrovascular disease by using herbal medicine has been applied for a long time, from which large amounts of medical experience and knowledge have been accumulated. Numerous natural bioactive compounds extracted from Chinese medicines exhibit neuroprotective activities, especially protecting the brain from ischemic injury. This review summarizes the mechanisms underlying cerebral ischemic patho...
Source: Journal of Integrative Neuroscience - June 29, 2020 Category: Neuroscience Authors: Yu L, Tao J, Zhao Q, Xu C, Zhang Q Tags: J Integr Neurosci Source Type: research

SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population
This study aimed to explore the possible association between rs2043211 and large-artery atherosclerosis stroke in Chinese and explain the possible mechanism. In total, 716 large-artery atherosclerosis stroke patients and 1088 controls were included in the study. Co-dominant, dominant, and recessive genetic models were constructed to evaluate the relationship between rs2043211 and large-artery atherosclerosis stroke risk by odds ratios with 95% confidence intervals. Stratified and interaction analyses were also done. We selected another 111 large-artery atherosclerosis stroke patients and measured the CARD8 levels in their ...
Source: Journal of Molecular Neuroscience - June 28, 2020 Category: Neuroscience Source Type: research

Association Between PSD95 Gene 3 ′UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population
AbstractTo study the association between the 3 ′UTR single nucleotide polymorphism ofPSD95 gene and the risk of acute ischemic stroke (AIS) in Chinese Han population.PSD95 gene 3 ′UTR rs191350575, rs314254, rs58197058, rs314253, rs314252, rs188777, rs11652753, rs79715480, and rs13331 genotypes of a total of 280 AIS patients and 280 healthy controls were analyzed. The prognosis outcomes of all AIS patients were analyzed after 3 years of follow-up. The risk of AIS in the rs 58197058 locus A allele was 1.76 times higher than the G allele (95%CI 1.53–1.92,p <  0.01). The rs314252 locus A allele carrier was 1.29 t...
Source: Journal of Molecular Neuroscience - May 13, 2020 Category: Neuroscience Source Type: research

CYP2B6 Polymorphisms Are Associated with Ischemic Stroke Risk in a Chinese Han Population
This study was conducted to explore the association betweenCYP2B6 polymorphisms and IS risk in a Chinese Han population. Four single-nucleotide polymorphisms (SNPs) inCYP2B6 from 477 cases and 495 controls were genotyped using the Agena MassARRAY. The odds ratio (OR) and 95% confidence interval (CI) were calculated under genetic models and haplotype analysis to assess the association between SNPs and IS risk. We found that rs2099361 was associated with an increased IS risk (CC vs. AA: overall: OR  = 1.85, 95% CI: 1.16–2.93,P = 0.010; age ≤ 60: OR = 1.94, 95% CI: 1.02–3.70,P = 0.045; male: OR =â€...
Source: Journal of Molecular Neuroscience - April 19, 2020 Category: Neuroscience Source Type: research

The Correlation Between Fall Prevention Knowledge and Behavior in Stroke Outpatients
BACKGROUND: Stroke outpatients have a high risk of falling. However, fall prevention measures in the community are insufficient to effectively reduce the fall rate among outpatients with stroke. We aimed to determine the correlation between fall prevention knowledge and behavior among outpatients with stroke and provide new strategies for community fall prevention. METHODS: We recruited 124 patients with stroke who were followed up in the outpatient department of a tertiary hospital in Zhuhai, China. Patients were assessed using a general information questionnaire, a fall prevention knowledge questionnaire for patients wit...
Source: Journal of Neuroscience Nursing - March 9, 2020 Category: Neuroscience Tags: Article Source Type: research

A NAC nomogram to predict the probability of three-month unfavorable outcome in Chinese acute ischemic stroke patients treated with mechanical thrombectomy
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Source: International Journal of Neuroscience - February 25, 2020 Category: Neuroscience Authors: Xiang Li Yang Zou Jue Hu Xue Mei Li Chao Ping Huang Ya Jie Shan Linda Nyame Zheng Zhao Chao Sun Mako Ibrahim Xi Ding Pan Chao Liu Zhi Hong Zhao Jian Jun Zou Source Type: research

Two Novel SNPs in the PLCL2 Gene Associated with Large Artery Atherosclerotic Stroke Identified by Fine-Mapping
AbstractA genome-wide association study (GWAS) reported that the single nucleotide polymorphism (SNP) rs4618210 in thePLCL2 gene is related to myocardial infarction (MI) in the Japanese population, but no study has examined the correlation ofPLCL2 with ischemic stroke (IS). The present study was designed to investigate whether the genetic variation inPLCL2 is associated with large artery atherosclerotic (LAA) stroke in a Han Chinese population. Tagging SNPs (tSNPs) of thePLCL2 gene were determined by a fine-mapping strategy and were genotyped by improved multiplex ligation detection reaction (iMLDR) technology in 669 LAA s...
Source: Journal of Molecular Neuroscience - January 21, 2020 Category: Neuroscience Source Type: research