Association Between PSD95 Gene 3 ′UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population

AbstractTo study the association between the 3 ′UTR single nucleotide polymorphism ofPSD95 gene and the risk of acute ischemic stroke (AIS) in Chinese Han population.PSD95 gene 3 ′UTR rs191350575, rs314254, rs58197058, rs314253, rs314252, rs188777, rs11652753, rs79715480, and rs13331 genotypes of a total of 280 AIS patients and 280 healthy controls were analyzed. The prognosis outcomes of all AIS patients were analyzed after 3 years of follow-up. The risk of AIS in the rs 58197058 locus A allele was 1.76 times higher than the G allele (95%CI 1.53–1.92,p <  0.01). The rs314252 locus A allele carrier was 1.29 times more likely to develop AIS than the G allele (95%CI 1.14–1.45,p <  0.01). The rs13331 locus A allele was a high-risk factor for ASI (adjusted OR = 1.18, 95%CI 1.05–1.33,p = 0.01). The interaction model between Alcohol, DM, Hypertension, rs58197058, and rs314252 predicted the highest accuracy of AIS, with a corresponding sensitivity of 75.36%, specificity of 85.00%, and cross-validation consistency (CVC) of 10/10 (p <  0.01). There was a significant correlation between rs58197058, rs314252, and rs13331 SNPs and plasma FG, TC, HDL-c, and LDL-c levels in AIS patients. ThePSD95 gene 3 ′UTR rs58197058, rs314252, and rs13331 SNPs are associated with the occurrence and prognosis of Chinese Han AIS patients.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research