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Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives.
Abstract The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. Later, under a lim...
Source: Acta Pharmacologica Sinica - September 22, 2020 Category: Drugs & Pharmacology Authors: Zhang XL, Li ZM, Ye JT, Lu J, Ye LL, Zhang CX, Liu PQ, Duan DD Tags: Acta Pharmacol Sin Source Type: research

Coagulopathy and thromboembolic events in patients with SARS-CoV-2 infection: pathogenesis and management strategies
AbstractIn October 2019, a viral infectious disease appeared in the city of Wuhan in China. A new betacoronavirus, SARS-CoV-2, has been recognized as the responsible pathogen in this infection. Although coronavirus disease is principally expressed as a pulmonary infection, critical SARS-CoV-2 infection is frequently complicated with coagulopathy, and thromboembolic events are recognizable in several patients. Dehydration, acute inflammatory condition, protracted immobilization during disease, existence of multiple cardiovascular risk factors such as diabetes, obesity or hypertension, previous coronary artery disease, ische...
Source: Annals of Hematology - August 13, 2020 Category: Hematology Source Type: research

Spectrum of Neurological Manifestations in Covid-19: A Review
Ravindra K GargNeurology India 2020 68(3):560-572 COVID-19, in most patients, presents with mild flu-like illness. Elderly patients with comorbidities, like hypertension, diabetes, or lung and cardiac disease, are more likely to have severe disease and deaths. Neurological complications are frequently reported in severely or critically ill patients with comorbidities. In COVID-19, both central and peripheral nervous systems can be affected. The SARS-CoV-2 virus causes the disease COVID-19 and has the potential to invade the brain. The SARS-CoV-2 virus enters the brain either via a hematogenous route or olfactory system. A...
Source: Neurology India - July 5, 2020 Category: Neurology Authors: Ravindra K Garg Source Type: research

Coronaviruses and Central Nervous System Manifestations
SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not expl...
Source: Frontiers in Neurology - June 22, 2020 Category: Neurology Source Type: research

Neurological involvement of coronavirus disease 2019: a systematic review
ConclusionsNeurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain –Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurol ogical diagnoses that can mimic COVID-19 during the pandemic.
Source: Journal of Neurology - June 18, 2020 Category: Neurology Source Type: research

Neurologic aspects of covid-19: a concise review.
In conclusion, nervous system symptoms can be observed during SARS-CoV2 infection of which headache and smell and taste disturbance are the main symptoms reported. Cerebrovascular complications can complicate the course of COVID-19 in apparently low-risk patients. GBS is a life-threatening manifestation of COVID-19. PMID: 32532937 [PubMed - as supplied by publisher]
Source: Infezioni in Medicina - June 14, 2020 Category: Infectious Diseases Tags: Infez Med Source Type: research

Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
Abstract 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019. Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing. Recently, Mao et al. [1] investigated the penetration potential of SARS-CoV-2 into the central nervous system in 214 patients. They reported that 36.4% of the patients had some neurologic findings which are ranged from nonsp...
Source: Current Neurovascular Research - May 21, 2020 Category: Neurology Authors: Bostanciklioglu M, Temiz E Tags: Curr Neurovasc Res Source Type: research

Unusual Symptoms of Coronavirus: What We Know So Far
While most people are familiar with the hallmark symptoms of COVID-19 by now—cough, fever, muscle aches, headaches and difficulty breathing—a new crop of medical conditions are emerging from the more than 4 million confirmed cases of the disease around the world. These include skin rashes, diarrhea, kidney abnormalities and potentially life-threatening blood clots. It’s not unusual for viruses to directly infect and affect different tissues and organs in the body, but it is a bit unusual for a primarily respiratory virus like SARS-CoV-2, which is responsible for COVID-19, to have such a wide-ranging reach...
Source: TIME: Health - May 19, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Falling stroke rates during COVID-19 pandemic at a comprehensive stroke center
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), began in Wuhan, China in December of 2019 and has led to a pandemic, accounting for more than 2.4 million worldwide infections and more than 160,000 deaths (as of April 20, 2020).1,2
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: J.E. Siegler, M.E. Heslin, L. Thau, A. Smith, T.G. Jovin Source Type: research

Falling stroke rates during COVID-19 pandemic at a Comprehensive Stroke Center: Cover title: Falling stroke rates during COVID-19
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), began in Wuhan, China in December of 2019 and has led to a pandemic, accounting for more than 2.4 million worldwide infections and more than 160,000 deaths (as of April 20, 2020).1,2
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: J.E. Siegler, M.E. Heslin, L. Thau, A. Smith, T.G. Jovin Source Type: research

Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights
An outbreak of an acute respiratory illness of unknown cause started in Wuhan, Hubei province, China on December 12, 2019.1,2 A new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in these patients. Subsequently, the identified acute respiratory illness was named coronavirus disease 2019 (COVID-19). Soon thereafter, the COVID-19 epidemic in China became a pandemic with a significant burden on healthcare and the world-wide economy. SARS-CoV-2 has been shown to be a distinct class of the beta coronaviruses (Beta-CoVs) with a 79.5% gene sequence homology to the severe ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2020 Category: Neurology Authors: Afshin A. Divani, Sasan Andalib, Mario Di Napoli, Simona Lattanzi, M. Shazam Hussain, Jos é Biller, Louise D. McCullough, M. Reza Azarpazhooh, Alina Seletska, Stephan A. Mayer, Michel Torbey Tags: Review Article Source Type: research

Application of Chinese Medicine in Acute and Critical Medical Conditions.
Abstract Western medicine is routinely used in developed nations as well as in Eastern countries, where traditional medicine is frequently used by a selection of patients or family member as a complement to mainstream Western medicine. Chinese medicine plays an important role in the treatment of chronic diseases, especially when Western medicine is not very effective. Many published reports have shown that Chinese medicine could also be successfully used in the management of acute and critical illnesses. Chinese medicine has a holistic view of the human body, and emphasizes individualization based on body balance ...
Source: The American Journal of Chinese Medicine - September 9, 2019 Category: Complementary Medicine Authors: Luo Y, Wang CZ, Hesse-Fong J, Lin JG, Yuan CS Tags: Am J Chin Med Source Type: research

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