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Association of cervical atherosclerosis on Doppler ultrasonography and postoperative delirium in patients undergoing spinal surgery: a single-center, retrospective, observational study
CONCLUSIONS: There was a significant association between POD and the prevalence of cervical atherosclerosis using the univariate logistic regression analysis. Furthermore, multivariate logistic regression analyses showed that older age and antiplatelet agent use were independently associated with POD.PMID:37326838 | DOI:10.1007/s00586-023-07823-0
Source: Atherosclerosis - June 16, 2023 Category: Cardiology Authors: Gentaro Kumagai Kanichiro Wada Toru Asari Yohshiro Nitobe Hirotaka Kinoshita Tetsuya Kushikata Kazuyoshi Hirota Yasuyuki Ishibashi Source Type: research

Arterial Thrombotic Complications of Tyrosine Kinase Inhibitors.
Abstract Abnormal expression or function of several classes of kinases contribute to the development of many types of solid and hematologic malignancies. TKs (tyrosine kinases) in particular play a role in tumor growth, metastasis, neovascularization, suppression of immune surveillance, and drug resistance. TKIs (tyrosine kinase inhibitors) targeted to TKs such as BCR-ABL1, VEGF receptors, PDGF receptors, have transformed therapy of certain forms of cancer by providing excellent efficacy with relatively low adverse event rates. Yet some of these agents have been associated with high rates of vascular events, presu...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 4, 2020 Category: Cardiology Authors: Wu MD, Moslehi JJ, Lindner JR Tags: Arterioscler Thromb Vasc Biol Source Type: research

Sodium Handling and Interaction in Numerous Organs.
Abstract Salt (NaCl) is a prerequisite for life. Excessive intake of salt, however, is said to increase disease risk including hypertension, arteriosclerosis, heart failure, renal disease, stroke, and cancer. Therefore, considerable research has been expended on the mechanism of sodium handling based on the current concepts of sodium balance. The studies have necessarily relied on relatively short-term experiments and focused on extremes of salt intake in humans. Ultra-long-term salt balance has received far less attention. We performed long-term salt balance studies at intakes of 6, 9, and 12 g/day and found that...
Source: American Journal of Hypertension - March 20, 2020 Category: Cardiology Authors: Minegishi S, Luft FC, Titze J, Kitada K Tags: Am J Hypertens Source Type: research

Causal Associations Between Serum Bilirubin Levels and Decreased Stroke Risk: A Two-Sample Mendelian Randomization Study.
CONCLUSIONS: Our findings provide evidence of significant causal relationship between high levels of bilirubin and decreased stroke risk in Korean population in agreement with observational approaches. This highlights the potential for bilirubin to serve as a therapeutic target for oxidative stress-related diseases such as stroke and suggests that previous findings were not a consequence of unmeasured confounding. PMID: 31801373 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 4, 2019 Category: Cardiology Authors: Choi Y, Lee SJ, Spiller W, Jung KJ, Lee JY, Kimm H, Back JH, Lee S, Jee SH Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart Association.
gy; and Council on Cardiovascular and Stroke Nursing Abstract Cardio-oncology has organically developed as a new discipline within cardiovascular medicine as a result of the cardiac and vascular adverse sequelae of the major advances in cancer treatment. Patients with cancer and cancer survivors are at increased risk of vascular disease for a number of reasons. First, many new cancer therapies, including several targeted therapies, are associated with vascular and metabolic complications. Second, cancer itself serves as a risk factor for vascular disease, especially by increasing the risk for thromboembolic events...
Source: Circulation - February 21, 2019 Category: Cardiology Authors: Campia U, Moslehi JJ, Amiri-Kordestani L, Barac A, Beckman JA, Chism DD, Cohen P, Groarke JD, Herrmann J, Reilly CM, Weintraub NL, American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biol Tags: Circulation Source Type: research

Resting Heart Rate Trajectory Pattern Predicts Arterial Stiffness in a Community-Based Chinese Cohort.
CONCLUSIONS: Long-term RHR pattern is a strong predictor of having arterial stiffness. PMID: 27908892 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 30, 2016 Category: Cardiology Authors: Chen S, Li W, Jin C, Vaidya A, Gao J, Yang H, Wu S, Gao X Tags: Arterioscler Thromb Vasc Biol Source Type: research

A Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Orally Administered Des-Aspartate Angiotensin I in Healthy Subjects
AbstractDes-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal models of human disease in which angiotensin II has been implicated, such as cardiac hypertrophy, neointima formation, arteriosclerosis, renal failure, post-infarction injuries, diabetes, viral infection, chemical-induced inflammation, heat stroke, cancer, and gamma radiation lethality. DAA-I crosses Caco-2 cells and is effective at sub-nanomolar concentrations. These two...
Source: Drugs in R&D - September 27, 2016 Category: Drugs & Pharmacology Source Type: research

Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging
; Mickael Tanter Non-invasive imaging deep into organs at microscopic scales remains an open quest in biomedical imaging. Although optical microscopy is still limited to surface imaging owing to optical wave diffusion and fast decorrelation in tissue, revolutionary approaches such as fluorescence photo-activated localization microscopy led to a striking increase in resolution by more than an order of magnitude in the last decade. In contrast with optics, ultrasonic waves propagate deep into organs without losing their coherence and are much less affected by in vivo decorrelation processes. However, their resolution is...
Source: Nature - November 25, 2015 Category: Research Authors: Claudia ErricoJuliette PierreSophie PezetYann DesaillyZsolt LenkeiOlivier CoutureMickael Tanter Tags: Letter Source Type: research

Gallstone Disease and the Risk of Ischemic Heart Disease.
CONCLUSIONS: In this large prospective study, the presence of GSD was associated with an increased risk of incident IHD, independent of other risk factors of cardiovascular disease. Our findings suggest novel prevention strategy to mitigate heart disease through improvement of gastrointestinal health. PMID: 26272939 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 13, 2015 Category: Cardiology Authors: Lv J, Qi L, Yu C, Guo Y, Bian Z, Chen Y, Yang L, Shen J, Wang S, Li M, Liu Y, Zhang L, Chen J, Chen Z, Li L Tags: Arterioscler Thromb Vasc Biol Source Type: research

Circulating CD40+ and CD86+ B Cell Subsets Demonstrate Opposing Associations With Risk of Stroke.
CONCLUSIONS: These observations provide evidence for an involvement of B cells in the incidence of stroke and suggest that both pathogenic and protective B cell subsets exist. PMID: 24202305 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 7, 2013 Category: Cardiology Authors: Mantani PT, Ljungcrantz I, Andersson L, Alm R, Hedblad B, Björkbacka H, Nilsson J, Nordin Fredrikson G Tags: Arterioscler Thromb Vasc Biol Source Type: research