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Total 3904 results found since Jan 2013.

Bradyarrhythmias in patients with atrial fibrillation
The increasing burden of atrial fibrillation (AF) and significant morbidity/mortality associated with this arrhythmia encourage screening it in clinical practice, as recommended in current guidelines. It means opportunistic screening (in patients over 65 years) or systematic screening (in people above 75 years) by using clinical examination, followed by an ECG, 24-hour ECG monitoring or continuous rhythm monitoring by a screening tool (including mobile or wearable device). In screen-positive cases, a definitive diagnosis of AF should always be obtained before providing an appropriate management.1 Symptomatic or asymptomati...
Source: Heart - August 11, 2023 Category: Cardiology Authors: Floria, M., Tanase, D. M. Tags: Editorials Source Type: research

The Price of Keeping the Rhythm: Increased Bleeding Risk in Patients with Atrial Fibrillation Concurrently Prescribed Amiodarone and Factor Xa Inhibitors
Atrial fibrillation is the most common sustained cardiac arrhythmia affecting nearly 2% of the population of the United States.1 Patients with atrial fibrillation are twice as likely to have a myocardial infarction and five-times as likely to have a stroke.1 Current guidelines recommend antiarrhythmic pharmacotherapy in patients with symptomatic atrial fibrillation as first-line management.2-4 Amiodarone is a very effective, and therefore, a commonly prescribed agent for this purpose.5 Anticoagulation is a key tenet in the management of atrial fibrillation due to the increased tendency of left atrial appendage clot formati...
Source: Journal of Cardiothoracic and Vascular Anesthesia - August 10, 2023 Category: Anesthesiology Authors: Nicolas Kumar, Manoj H. Iyer, Adam Dalia, Amit Bardia Tags: Editorial Source Type: research

Signaling Pathways Associated with Prior Cardiovascular Events in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. A subset of patients experience major adverse cardiovascular event (MACE) including arrhythmias, stroke, and heart failure. However, molecular mechanisms underlying MACE in HCM are still not well understood. We therefore conducted a multicenter case-control study of patients with HCM comparing those with and without prior history of MACE to identify dysregulated signaling pathways through plasma proteomics profiling.
Source: Journal of Cardiac Failure - August 7, 2023 Category: Cardiology Authors: Charlotte Lee, Lusha W. Liang, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach Reilly, Yuichi J. Shimada Source Type: research

LB-007 Selective brain cooling is possible via CSF exchange with double lumen EVD-proof of concept in porcine stroke model
ConclusionWe are first to describe that selective brain cooling is possible via CSF exchange with double lumen EVD to achieve significant temperature difference between body core and brain. The timing and rate of selective cooling needs to be established as cause of arrhythmias before starting human trials.DisclosuresB. Rezai Jahromi: 1; C; IRRAS. 2; C; Neurovascular Innovations. 4; C; Neurovascular Innovations. 6; C; Helsinki Surgical Instruments. N. Järveläinen: None. J. Kauhanen: None. V. Zamotin: None. N. Brandmeir: 1; C; IRRAS. 2; C; IRRAS. M. Niemelä: None. S. Ylä-Herttuala: None.
Source: Journal of NeuroInterventional Surgery - August 3, 2023 Category: Neurosurgery Authors: Rezai Jahromi, B., Järveläinen, N., Kauhanen, J., Zamotin, V., Brandmeir, N., Niemelä, M., Ylä-Herttuala, S. Tags: SNIS 20th annual meeting late-breaking oral abstracts Source Type: research

A multiscale predictive digital twin for neurocardiac modulation
J Physiol. 2023 Aug 1. doi: 10.1113/JP284391. Online ahead of print.ABSTRACTCardiac function is tightly regulated by the autonomic nervous system (ANS). Activation of the sympathetic nervous system increases cardiac output by increasing heart rate and stroke volume, while parasympathetic nerve stimulation instantly slows heart rate. Importantly, imbalance in autonomic control of the heart has been implicated in the development of arrhythmias and heart failure. Understanding of the mechanisms and effects of autonomic stimulation is a major challenge because synapses in different regions of the heart result in multiple chang...
Source: The Journal of Physiology - August 2, 2023 Category: Physiology Authors: Pei-Chi Yang Adam Rose Kevin R DeMarco John R D Dawson Yanxiao Han Mao-Tsuen Jeng Robert D Harvey L Fernando Santana Crystal M Ripplinger Igor Vorobyov Timothy J Lewis Colleen E Clancy Source Type: research

E-261 Variability of response on prophylactic prasugrel for endovascular treatment of intracranial aneurysms: clinical implications
ConclusionIn the neurointerventional field, high BMI and prior use of antithrombotic agents were related to HTPR, and low BMI was associated with LTPR on prophylactic prasugrel. High hematocrit levels decreased the risk of HTPR. When preparing endovascular treatment for intracranial aneurysms, attention to patients with these clinical features is required to address the possibility of ischemic or bleeding complications.Abstract E-261 Table 1Risk factor analysis of high on-treatment platelet reactivity (HTPR) Variables Univariate Analysis Multivariate Analysis OR (95% CI) P OR (95% CI) P Age 1.02 (0.97-1.06) 0.53 Female o...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Son, Y., Hong, N. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Sex Differences in Atrial Fibrillation
AbstractPurpose of ReviewAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The estimated lifetime risk of developing AF is higher in men; however, due to differences in life expectancy, the overall prevalence is higher among women, particularly in the older age group. Sex differences play an important role in the pathophysiology, presentation, and clinical outcomes of AF. Awareness of these differences minimizes the potential for disparities in AF management. Our review summarizes the current literature on sex differences in AF, including the epidemiology, pathophysiology, risk factors, clinical sym...
Source: Current Cardiology Reports - July 28, 2023 Category: Cardiology Source Type: research

Influence of continuous positive airway pressure treatment on auditory event-related potentials p300
Acta Clin Croat. 2022 Nov;61(3):373-378. doi: 10.20471/acc.2022.61.03.01.ABSTRACTObstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by obstructions of the upper airway during sleep, resulting in repetitive breathing pauses accompanied by oxygen desaturation and arousal from sleep. OSA can be successfully treated with continuous positive airway pressure (CPAP), weight loss, positional therapy, oral appliances, hypoglossal nerve stimulation, and surgical procedures. It has been observed that untreated OSA is related to chronic disorders including hypertension, arrhythmias, congestive heart fail...
Source: Acta Clinica Croatica - July 26, 2023 Category: General Medicine Authors: Jelena Šarić-Jurić Stjepan Juri ć Ivana Markovi ć Source Type: research

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