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Condition: Arrhythmia

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Total 3904 results found since Jan 2013.

PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research

To block or not to block: Targeting SK channels in diseased hearts
Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 1% of general population and reaching over 10% in advanced age in the USA. Atrial fibrillation drastically increases the risk of stroke and promotes development of cardiomyopathy and congestive heart failure. Existing pharmacological approaches using β-blockers and inhibitors of Na+, Ca2+ and K+ channels to treat AF are effective only in 50% of cases. Furthermore, these drugs could affect ventricular tissue promoting proarrhythmic changes in electrical conduction, intracellular Ca2+ homeostasis, or action potential duration (APD).
Source: Journal of Molecular and Cellular Cardiology - September 22, 2023 Category: Cytology Authors: Dmitry Terentyev, Andriy E. Belevych, Bum-Rak Choi, Shanna Hamilton Source Type: research

Differential Cardiovascular Outcomes of Each Antihypertensive Drug Class in Patients With Hypertension and Breast Cancer Undergoing Doxorubicin-Containing Chemotherapy
CONCLUSION: RAS inhibitors are preferred for the treating hypertension and improving CV outcomes in patients with hypertension and breast cancer undergoing DOX-containing chemotherapy, particularly in patients with comorbid diabetes. However, CCBs are equivalent to RAS inhibitors and are more favorable than BBs and TDs in terms of improving CV outcomes.PMID:37704380 | DOI:10.4048/jbc.2023.26.e34
Source: Journal of Breast Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Hui-Jeong Hwang Sang-Ah Han Source Type: research

Experience and insights from a prolonged electrocardiographic monitorization with a wearable system after an embolic stroke of unknown source
ConclusionPCMw represents a feasible non-invasive device that could reliably detect subclinical AF episodes after an ESUS. Diagnostic yield was significatively higher when used within the first 30  days after the event, especially in selected patients. UAE were common, but did not impact prognosis.
Source: Pacing and Clinical Electrophysiology : PACE - September 11, 2023 Category: Cardiology Authors: Daniel Castro, Jorge Toquero ‐Ramos, Diego Jiménez‐Sánchez, Eusebio García‐Izquierdo, Víctor Castro‐Urda, Cristina Aguilera‐Agudo, Fernando Domínguez, Daniel García‐Rodríguez, Paula Vela‐Martín, Paloma Remior, Pablo Gómez Tags: ORIGINAL ARTICLE Source Type: research

Clinical Characteristics and Outcomes of Chagas Disease in the United States: A Multicenter Retrospective Analysis
Am J Trop Med Hyg. 2023 Sep 11:tpmd230361. doi: 10.4269/ajtmh.23-0361. Online ahead of print.ABSTRACTChagas disease affects approximately 300,000 patients in the United States. We evaluated a multicenter U.S.-based network to obtain clinical characteristics and outcomes of chronic Chagas disease by disease forms. This was a U.S.-based, multicenter, population-based, retrospective cohort study. We queried TriNetX, a global research network, to identify patients with dual-positive IgG serology for Trypanosoma cruzi. We captured outcomes of interest for up to 5 years. We found 429 patients with evidence of dual-positive T. cr...
Source: The American Journal of Tropical Medicine and Hygiene - September 11, 2023 Category: Tropical Medicine Authors: Andr és F Henao-Martínez Christian Olivo-Freites Nelson I Agudelo Higuita Carolina Ferraz Carlos Franco-Paredes Jose Tuells Laila Woc-Colburn Salvador Villalpando-Carri ón Daniel B Chastain Anis Rassi Source Type: research