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Condition: Aortic Stenosis
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Total 1228 results found since Jan 2013.
Clonal Hematopoiesis and the Heart: a Toxic Relationship
AbstractPurpose of ReviewClonal
hematopoiesis (CH) refers to the expansion of hematopoietic stem cell clones and their cellular progeny due to somatic mutations, mosaic chromosomal alterations (mCAs), or copy number variants which naturally accumulate with age. CH has been linked to increased risk of blood cancers, but CH has also been linked to adverse cardiovascular outcomes.Recent FindingsA combination of clinical outcome studies and mouse models have offered strong evidence that CH mutations either correlate with or cause atherosclerosis, diabetes mellitus, chronic kidney disease, heart failure, pulmonary hypertensi...
Source: Current Oncology Reports - March 15, 2023 Category: Cancer & Oncology Source Type: research
Thirty-day and one-year outcomes of the Navitor transcatheter heart valve in patients with aortic stenosis: the prospective, multicentre, global PORTICO NG Study
CONCLUSIONS: The PORTICO NG Study demonstrates low rates of adverse events and PVL up to 1 year in patients at high or extreme surgical risk, confirming the safety and efficacy of the Navitor THV system.PMID:36895190 | DOI:10.4244/EIJ-D-22-01108
Source: EuroIntervention - March 10, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Lars Sondergaard Antony S Walton Stephen G Worthley Dave Smith Bassem Chehab Ganesh Manoharan Gerald Yong Francesco Bedogni Nicholas Bates Michael J Reardon Source Type: research
Meta-Analysis of Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement
Transcatheter aortic valve replacement (TAVR) has emerged as an effective therapy for patients with severe aortic stenosis, irrespective of surgical risks.1 Stroke due to cerebral embolization of debris is a devastating periprocedural complication of TAVR and is associated with poor outcomes. The risk of stroke could be decreased by capturing the debris using cerebral embolic protection (CEP) devices.2 An analysis of the TVT (Transcatheter Valve Therapy) Registry showed that CEPs were used in 28% of centers and 13% of all procedures.
Source: The American Journal of Cardiology - February 27, 2023 Category: Cardiology Authors: Ahmad Al-Abdouh, Mohammed Mhanna, Ahmad Jabri, Taha Ahmed, Ahmed M. Altibi, Fares Ghanem, Laith Alhuneafat, Ayman Albadawi, Mahmoud Barbarawi, Nakeya Dewaswala, Huzefa Bhopalwala, Amartya Kundu, Islam Y. Elgendy Source Type: research
Failure of Guidelines and Consensus Statements to Recommend Follow-up for Chronic Cardiovascular Conditions
Follow-up of chronic medical conditions affects subsequent outcomes through adherence and early detection of progression of disease. Examples include adherence to anticoagulation therapy improving stroke rates and survival in atrial fibrillation,1 adherence to guideline-directed medical therapy improving survival in heart failure,2,3 and regular clinic follow-up of asymptomatic aortic stenosis identifying the optimal time for valve replacement.4,5 While close follow-up of chronic cardiac conditions can improve outcomes,6 and lack of follow-up is a barrier to medication adherence,7 we have observed that practitioners in our...
Source: Heart and Lung - February 16, 2023 Category: Intensive Care Authors: Krishna Patel, Camila M. Maestas, Oksana Petrechko, Himabindu Boja, James C. Blankenship Source Type: research
Outcomes of Transcatheter Aortic Valve Replacement in Patients with Concomitant Aortic Regurgitation
CONCLUSIONS: TAVR can be safely performed in patients with mixed valvular disease, yielding comparable outcomes as in isolated AS.PMID:36791833 | DOI:10.1016/j.athoracsur.2023.02.008
Source: The Annals of Thoracic Surgery - February 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Sarah Yousef Valentino Bianco Dustin Kliner Catalin Toma Derek Serna-Gallegos David West Amber Makani Jianhui Zhu Floyd W Thoma James A Brown Takuya Ogami Ibrahim Sultan Source Type: research
Fluid Mechanical Effects of Fetal Aortic Valvuloplasty for Cases of Critical Aortic Stenosis with Evolving Hypoplastic Left Heart Syndrome
Ann Biomed Eng. 2023 Feb 13. doi: 10.1007/s10439-023-03152-x. Online ahead of print.ABSTRACTFetuses with critical aortic stenosis (FAS) are at high risk of progression to HLHS by the time of birth (and are thus termed "evolving HLHS"). An in-utero catheter-based intervention, fetal aortic valvuloplasty (FAV), has shown promise as an intervention strategy to circumvent the progression, but its impact on the heart's biomechanics is not well understood. We performed patient-specific computational fluid dynamic (CFD) simulations based on 4D fetal echocardiography to assess the changes in the fluid mechanical environment in the...
Source: Annals of Biomedical Engineering - February 13, 2023 Category: Biomedical Engineering Authors: Hong Shen Wong Binghuan Li Andreas Tulzer Gerald Tulzer Choon Hwai Yap Source Type: research
Rescue aortic valvuloplasty for severe aortic stenosis is simple and effective in severely hemodynamically compromised patients presenting to centers without on-site heart surgery or TAVI facilities
AbstractManagement of high-risk patients with severe aortic stenosis (AS) is a challenging issue. The prognosis of patients with AS presenting with therapy-refractory pulmonary edema (RPE) or cardiogenic shock (CS) remains poor. The purpose of this study was to assess the 30-day mortality of rescue percutaneous balloon aortic valvuloplasty (PBAV) in AS patients presenting with RPE or CS in a community-based hospital without on- site heart surgery. From January 2016 to February 2019, we identified consecutively admitted patients with CS or RPE related to severe AS who underwent emergent PBAV. The primary end...
Source: Heart and Vessels - February 13, 2023 Category: Cardiology Source Type: research
Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients
CONCLUSIONS: Thrombocytopenia was common after Perceval sutureless AVR, although its impact was not significant. Although Perceval sutureless AVR was found to be a safe and effective option, preoperative assessment of potential bleeding should be performed and the Perceval valve should not be used for patients with a high bleeding risk.PMID:36709983 | DOI:10.1253/circj.CJ-22-0587
Source: Circulation Journal - January 29, 2023 Category: Cardiology Authors: Taisuke Nakayama Yoshitsugu Nakamura Fumiaki Shikata Masaki Ushijima Yuto Yasumoto Daiki Yoshiyama Miho Kuroda Shintaro Sawa Ryo Tsuruta Akira Furutachi Takuya Narita Yujiro Ito Source Type: research
Routine cerebral embolic protection in transcatheter aortic valve implantation: rationale and design of the randomised British Heart Foundation PROTECT-TAVI trial
EuroIntervention. 2023 Jan 26:EIJ-D-22-00713. doi: 10.4244/EIJ-D-22-00713. Online ahead of print.ABSTRACTTranscatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis. Cerebral embolic protection (CEP) devices may impact periprocedural stroke by capturing debris destined for the brain. However, there is a lack of high-quality randomised trial evidence supporting the use of CEP during TAVI. The British Heart Foundation (BHF) PROTECT-TAVI trial will address whether the routine use of CEP reduces the incidence of stroke in patients undergoing TAVI. BHF PROTECT-TAVI is a prospective, open-label...
Source: EuroIntervention - January 27, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Rajesh K Kharbanda Alexander David Perkins James Kennedy Adrian P Banning Andreas Baumbach Daniel J Blackman Matthew Dodd Richard Evans David Hildick-Smith Zahra Jamal Peter Ludman Stephen Palmer Rodney Stables Tim Clayton Source Type: research
