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Specialty: Allergy & Immunology
Condition: Thrombosis

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Total 61 results found since Jan 2013.

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
CONCLUSION: The mortality of individuals with SLE due to COVID-19 is comparable to the general population but with higher risks of hospitalisation, ICU admission, mechanical ventilation, stroke, VTE and sepsis. The presence of nephritis increases the risk of AKI, thus probably increasing hospitalisation and sepsis.PMID:34649723 | PMC:PMC8501265 | DOI:10.1016/j.jaut.2021.102730
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury
Ischemic stroke is one of the leading causes of morbidity and mortality globally. Hundreds of clinical trials have proven ineffective in bringing forth a definitive and effective treatment for ischemic stroke, except a myopic class of thrombolytic drugs. That, too, has little to do with treating long-term post-stroke disabilities. These studies proposed diverse options to treat stroke, ranging from neurotropic interpolation to venting antioxidant activity, from blocking specific receptors to obstructing functional capacity of ion channels, and more recently the utilization of neuroprotective substances. However, state of t...
Source: Frontiers in Immunology - October 7, 2021 Category: Allergy & Immunology Source Type: research

Acute generalized exanthematous pustulosis to a novel oral anticoagulant (apixaban)
Non-vitamin K antagonist oral anticoagulants or novel oral anticoagulants (NOACs) are increasingly used in the prevention of stroke in atrial fibrillation and in the prevention and treatment of venous thromboembolism (VTE). NOACs include direct thrombin inhibitor dabigatran and factor Xa inhibitors apixaban, edoxaban and rivaroxaban. Severe cutaneous adverse reactions are rare with definite cases of drug reaction with eosinophilia and systemic symptoms (DRESS) attributed to both rivaroxaban and apixaban1,2.
Source: Annals of Allergy, Asthma and Immunology - August 2, 2021 Category: Allergy & Immunology Authors: Suran L Fernando, Jamma Li, Chris Toon, Chris Weir Source Type: research

Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF- κB mediated neutrophil infiltration in thromboembolic stroke rats
Int Immunopharmacol. 2021 Feb 28;94:107507. doi: 10.1016/j.intimp.2021.107507. Online ahead of print.ABSTRACTHemorrhagic transformation (HT) is a frequent complication of ischemic stroke after thrombolytic therapy and seriously affects the prognosis of stroke. Due to the limited therapeutic window and hemorrhagic complications, tissue plasminogen activator (t-PA) is underutilized in acute ischemic stroke. Currently, there are no clinically effective drugs to decrease the incidence of t-PA-induced HT. Hypoxia-inducible factor 1 (HIF-1) is an important transcription factor that maintains oxygen homeostasis and mediates neuro...
Source: International Immunopharmacology - March 3, 2021 Category: Allergy & Immunology Authors: Linglei Kong Yinzhong Ma Zhiyuan Wang Nannan Liu Guodong Ma Chengdi Liu Ruili Shi Guanhua Du Source Type: research

Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13
Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for thrombosis and inflammation. During these processes, a complex series of events, including endothelial activation, NET formation, VWF secretion, and blood cell adhesion, aggregation and activation, occurs in an ordered manner in the vasculature. The adhesive activity of VWF multimers is regulated by a specific metalloprotease ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13). Increasing evidence indicates that the interaction between NETs and VWF contributes to arterial and venous thrombos...
Source: Frontiers in Immunology - December 2, 2020 Category: Allergy & Immunology Source Type: research

Delayed hypersensitivity reactions to edoxaban
Edoxaban is the fourth approved Direct Oral AntiCoagulant (DOAC) that has been introduced into the European market (2015), after dabigatran (2008), rivaroxaban (2008) and apixaban (2011). Dabigatran is the only direct thrombin inhibitor, whereas apixaban, edoxaban, and rivaroxaban are factor-Xa inhibitors. In a few years DOACs' use steadily increased in clinical practice for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF) [1], as well as for treatment and prevention of recurrent deep vein thrombosis (DVT) and pulmonary embolism (PE)[2].
Source: Annals of Allergy, Asthma and Immunology - August 27, 2020 Category: Allergy & Immunology Authors: Laura Franceschini, Giulia Carli, Giancarlo Landini, Daniela Matarrese, Alessandro Farsi Tags: Letters Source Type: research

Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead
Atherosclerosis is a chronic process associated with arterial inflammation, the accumulation of lipids, plaque formation in vessel walls, and thrombosis with late mortal complications such as myocardial infarction and ischemic stroke. Immune and inflammatory responses have significant effects on every phase of atherosclerosis. Increasing evidence has shown that both innate and adaptive “arms” of the immune system play important roles in regulating the progression of atherosclerosis. Accumulating evidence suggests that a unique type of innate immune cell, termed dendritic cells (DCs), play an important role as central i...
Source: Frontiers in Immunology - July 28, 2020 Category: Allergy & Immunology Source Type: research

TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model
In this study, a middle-cerebral-artery occlusion/reperfusion (MCAO/R) model was used in adult male Sprague-Dawley rats in vivo, and cultured neurons were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) to simulate cerebral ischemia-reperfusion (I/R) injury in vitro. We found that the protein level of TMEM16F was significantly increased at 12 h after I-R injury both in vivo and in vitro, and reversible phosphatidylserine exposure was confirmed in neurons undergoing I/R injury in vitro. Additionally, we constructed a LV-TMEM16F-RNAi transfection system to suppress the expression of TMEM16F during and after cereb...
Source: Frontiers in Immunology - July 6, 2020 Category: Allergy & Immunology Source Type: research

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke
von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα (GPIbα). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, are also involved in inflammatory processes, forming intriguing links between hemostasis, thrombosis, and inflammation. The so-called “thrombo-inflammatory” nature of the VWF-platelet axis becomes increasingly recognized in different cardiovascular pathologies, making it a potential therapeutic target to interfere with both...
Source: Frontiers in Immunology - December 16, 2019 Category: Allergy & Immunology Source Type: research

Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF- κB Signaling Pathways
In conclusion, tetramethylpyrazine protected BMECs and inhibited platelets adhesion to BMECs after OGD/R injury, which was partially mediated by inhibiting P38 MAPK and NF-κB signaling pathways.
Source: Inflammation - November 12, 2019 Category: Allergy & Immunology Source Type: research

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury
Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressive stroke can still develop despite successful recanalization, a process termed “reperfusion injury.” Mounting experimental evidence suggests that platelets and T cells contribute to cerebral ischemia/reperfusion injury, and ischemic stroke is increasingly considered a thrombo-inflammatory disease. The inte...
Source: Frontiers in Immunology - October 31, 2019 Category: Allergy & Immunology Source Type: research

A new ELISA method for the measurement of total α2-plasmin inhibitor level in human body fluids.
In conclusion, our ELISA enables accurate and fast measurement of total free α2-PI in human body fluids. PMID: 31129263 [PubMed - as supplied by publisher]
Source: Journal of Immunological Methods - May 22, 2019 Category: Allergy & Immunology Authors: Teráz-Orosz A, Csapó A, Bagoly Z, Székely E, Tóth E, Kovács B, Bereczky Z, Muszbek L, Katona É Tags: J Immunol Methods Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research