Acute generalized exanthematous pustulosis to a novel oral anticoagulant (apixaban)

Non-vitamin K antagonist oral anticoagulants or novel oral anticoagulants (NOACs) are increasingly used in the prevention of stroke in atrial fibrillation and in the prevention and treatment of venous thromboembolism (VTE). NOACs include direct thrombin inhibitor dabigatran and factor Xa inhibitors apixaban, edoxaban and rivaroxaban. Severe cutaneous adverse reactions are rare with definite cases of drug reaction with eosinophilia and systemic symptoms (DRESS) attributed to both rivaroxaban and apixaban1,2.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research