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Specialty: Hematology
Condition: Thrombosis

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Total 1625 results found since Jan 2013.

Venous Thromboembolism in Patients With Prior Stroke
In conclusion, patients with VTE and prior stroke were more than twice as likely to die while hospitalized and within 30 days of VTE diagnosis.
Source: Clinical and Applied Thrombosis/Hemostasis - December 12, 2013 Category: Hematology Authors: Piazza, G., Goldhaber, S. Z., Kroll, A., Goldberg, R. J., Emery, C., Spencer, F. A. Tags: Original Articles Source Type: research

Evaluation of patients' attitudes towards stroke prevention and bleeding risk in atrial fibrillation.
In conclusion, there was a substantial amount of inter-patient variability, and often extreme differences in opinion regarding tolerance of bleeding risk in the context of stroke prevention in atrial fibrillation. These findings highlight the importance of considering patient preferences when deciding on SPAF therapy. PMID: 24337399 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 12, 2013 Category: Hematology Authors: Lahaye S, Regpala S, Lacombe S, Sharma M, Gibbens S, Ball D, Francis K Tags: Thromb Haemost Source Type: research

Stroke prevention in atrial fibrillation: An Asian perspective.
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. In 2050, it is estimated that there will be 72 million AF patients in Asia, accounting for almost 2.9 million patients suffering from AF-associated stroke. Asian AF patients share similar risk factor profiles as non-Asians, except that more Asians have a history of previous stroke. Clinical challenges are evident in the field of stroke prevention in AF, amongst Asians. Existing stroke and bleeding risk scores have not been well-validated in Asians. Asians are prone to bleeding when treated with warfarin, and the optimal internationa...
Source: Thrombosis and Haemostasis - February 6, 2014 Category: Hematology Authors: Chiang CE, Wang KL, Lip GY Tags: Thromb Haemost Source Type: research

Circulating desphospho‐uncarboxylated matrix Gla protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP concentrations, reflecting a poor vitamin K status, are associated with increased CHD or stroke risk in the general population.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 1, 2014 Category: Hematology Authors: Geertje W. Dalmeijer, Yvonne T. Schouw, Elke J. Magdeleyns, Cees Vermeer, W.M. Monique Verschuren, Jolanda M.A. Boer, Joline W.J. Beulens Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Improving prediction of recanalization in acute large‐vessel occlusive stroke
ConclusionsAcute endovascular treatment is the single most important factor promoting recanalization in acute ischemic stroke. The presence of extracranial vessel stenosis or occlusion decreases recanalization rates. In patients with intracranial occlusions, higher NIHSS score and ASPECTS and normal vigilance facilitate recanalization. Clinical use of these predictors could influence recanalization strategies in individual patients.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: P. Vanacker, D. Lambrou, A. Eskandari, P. Maeder, R. Meuli, G. Ntaios, P. Michel Tags: Original Article Source Type: research

Circulating desphospho‐uncarboxylated matrix γ‐carboxyglutamate protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP levels, reflecting poor vitamin K status, are associated with increased CHD or stroke risk in the general population.
Source: Journal of Thrombosis and Haemostasis - June 19, 2014 Category: Hematology Authors: G. W. Dalmeijer, Y. T. Schouw, E. J. Magdeleyns, C. Vermeer, W. M. M. Verschuren, J. M. A. Boer, J. W. J. Beulens Tags: Original Article Source Type: research

Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke
Abstract In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1 % men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 ...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Relationship Between Red Cell Distribution Width and Stroke in Patients With Stable Chronic Heart Failure: A Propensity Score Matching Analysis
Conclusion: In conclusion, this study demonstrated that RDW may be important hematological indices for stroke in patients with HF using propensity score analysis.
Source: Clinical and Applied Thrombosis/Hemostasis - February 2, 2015 Category: Hematology Authors: Kaya, A., Isik, T., Kaya, Y., Enginyurt, O., Gunaydin, Z. Y., Iscanli, M. D., Kurt, M., Tanboga, I. H. Tags: Original Articles Source Type: research

Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study.
CONCLUSIONS: These results support the importance of contact activation pathway-dependent TG as a risk factor for ischemic stroke and indicate the importance of F12 SNPs on TG ex vivo and in vivo. This article is protected by copyright. All rights reserved. PMID: 26286125 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 19, 2015 Category: Hematology Authors: Olson NC, Butenas S, Lange LA, Lange EM, Cushman M, Jenny NS, Walston J, Souto JC, Soria JM, Chauhan G, Debette S, Longstreth WT, Seshadri S, Reiner AP, Tracy RP Tags: J Thromb Haemost Source Type: research

Haemostatic biomarkers are associated with long-term recurrent vascular events after ischaemic stroke.
In conclusion, plasma levels of haemostatic factors were associated with vascular death and coronary events, but not with recurrent stroke. Our results suggest that the predictive value of biomarkers differ by specific outcome measure and subgroup of patients. PMID: 27357914 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 29, 2016 Category: Hematology Authors: Pedersen A, Redfors P, Lundberg L, Gils A, Declerck PJ, Nilsson S, Jood K, Jern C Tags: Thromb Haemost Source Type: research

Microfluidic coagulation assay for monitoring anticoagulant therapy in acute stroke patients.
In conclusion, the SAW-CT assay is capable to monitor anticoagulant level and effect in patients receiving dabigatran, rivaroxaban and the VKA phenprocoumon. It has a limited sensitivity for apixaban-detection. If specific SAW-CT results were used as cut-offs, SAW-CT yields high diagnostic accuracy to exclude relevant rivaroxaban and dabigatran concentrations in stroke-patients. PMID: 28124061 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 25, 2017 Category: Hematology Authors: Bluecher A, Meyer Dos Santos S, Ferreirós N, Labocha S, Meyer Dos Santos IM, Picard-Willems B, Harder S, Singer OC Tags: Thromb Haemost Source Type: research

Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
Thrombolytic therapy using tissue plasminogen activator (tPA) in acute stroke is associated with increased risks of cerebral hemorrhagic transformation and angioedema. Although plasma kallikrein (PKal) has been implicated in contributing to both hematoma expansion and thrombosis in stroke, its role in the complications associated with the therapeutic use of tPA in stroke is not yet available. We investigated the effects of tPA on plasma prekallikrein (PPK) activation and the role of PKal on cerebral outcomes in a murine thrombotic stroke model treated with tPA. We show that tPA increases PKal activity in vitro in both muri...
Source: Blood - April 20, 2017 Category: Hematology Authors: Simao, F., Ustunkaya, T., Clermont, A. C., Feener, E. P. Tags: Thrombosis and Hemostasis Source Type: research

The C ‐reactive protein gene polymorphism predicts the risk of thromboembolic stroke in atrial fibrillation: a more than 10‐year prospective follow‐up study
ConclusionThe CRP gene triallelic polymorphism and the CRP level are associated with the risk of incident thromboembolic stroke in patients with AF.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 1, 2017 Category: Hematology Authors: Sheng ‐Nan Chang, Ling‐Ping Lai, Fu‐Tien Chiang, Jiunn‐Lee Lin, Juey‐Jen Hwang, Chia‐Ti Tsai Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Comparison of body mass index, waist circumference, and waist-height ratio in predicting functional outcome following ischemic stroke
AbstractAlthough a positive association between body mass index (BMI) and stroke incidence has been reported, having a higher BMI is known to be advantageous in surviving and recovering from stroke. The association between adiposity and stroke incidence is more evident for measures of abdominal obesity than for general obesity. The aim of our study was to compare BMI, waist circumference, and waist-height ratio (WHR) as predictors of 3-month functional outcome in stroke patients. The BMI, waist circumference, and WHR of acute stroke patients were divided into sex-specific quartiles. A total of 605 female and 727 male patie...
Source: Journal of Thrombosis and Thrombolysis - May 31, 2017 Category: Hematology Source Type: research

Stroke prevention in atrial fibrillation: Past, present and future. Comparing the guidelines and practical decision-making.
Abstract Concepts and our approaches to stroke prevention in atrial fibrillation (AF) have changed markedly over the last decade. There has been an evolution over the approach to stroke and bleeding risk assessment, as well as new treatment options. An increasing awareness of AF has led to calls to improve the detection of and population screening for AF. Stroke and bleeding risk assessment continues to evolve, and the ongoing debate on balance between simplicity and practicality, against precision medicine will continue. In this review article, we provide an overview of past, present and the (likely) future conce...
Source: Thrombosis and Haemostasis - June 9, 2017 Category: Hematology Authors: Lip G, Lip GYH, Freedman B, De Caterina R, Potpara TS Tags: Thromb Haemost Source Type: research