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Specialty: Hematology
Condition: Thrombosis

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Total 1625 results found since Jan 2013.

Oral Contraceptive Use and Incident Stroke in Women with Sickle Cell Disease
Oral contraceptives increase the risk of ischemic stroke among women. However, the effect is not studied in the stroke prone sickle cell disease population. We want to determine the rate of incident stroke among women with sickle cell disease (SCD) enrolled in a large cohort with longitudinal follow-up.
Source: Thrombosis Research - April 13, 2015 Category: Hematology Authors: Adnan I. Qureshi, Ahmed A. Malik, Malik M. Adil, M. Fareed K. Suri Tags: Regular article Source Type: research

Clopidogrel Plus Aspirin Prevents Early Neurologic Deterioration and Improves 6-Month Outcome in Patients With Acute Large Artery Atherosclerosis Stroke
Conclusion: Clopidogrel plus aspirin is superior to aspirin alone for reducing END and RIS within 30 days and improves outcomes in certain subgroups at 6 months.
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Wang, C., Yi, X., Zhang, B., Liao, D., Lin, J., Chi, L. Tags: Original Articles Source Type: research

Stroke in atrial fibrillation and improving the identification of ‘high risk’ patients: the crossroads of immunity and thrombosis
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 25, 2015 Category: Hematology Authors: Eduard Shantsila, Gregory YH Lip Tags: Commentary Source Type: research

Factoring in Factor VIII With Acute Ischemic Stroke
There is growing research interest into the etiologies of cryptogenic stroke, in particular as it relates to hypercoagulable states. An elevation in serum levels of the procoagulant factor VIII is recognized as one such culprit of occult cerebral infarctions. It is the objective of the present review to summarize the molecular role of factor VIII in thrombogenesis and its clinical use in the diagnosis and prognosis of acute ischemic stroke. We also discuss the utility of screening for serum factor VIII levels among patients at risk for, or those who have experienced, ischemic stroke.
Source: Clinical and Applied Thrombosis/Hemostasis - September 2, 2015 Category: Hematology Authors: Siegler, J. E., Samai, A., Albright, K. C., Boehme, A. K., Martin-Schild, S. Tags: Review Source Type: research

Prevention and follow-up in thromboembolic ischemic stroke: Do we need to think out of the box?
Stroke is one of the most debilitating thrombotic diseases, and world-wide it is estimated that by, 2030 23 million people will be affected. Except for the impact on the individual families, the world economy is also affected adversely. Although the medical treatment and knowledge of stroke are both increasing and well-researched, we still do not see a light in the tunnel. Currently various diagnostic tests are employed to determine the specific type of ischemic stroke as classified by the TOAST criteria.
Source: Thrombosis Research - November 4, 2015 Category: Hematology Authors: Albe C. Swanepoel, Etheresia Pretorius Tags: Review Article Source Type: research

High residual platelet reactivity (HRPR) for adenosine diphosphate (ADP) stimuli is a determinant factor for long-term outcomes in acute ischemic stroke with anti-platelet agents: The meaning of HRPR after ADP might be more prominent in large atherosclerotic infarction than other subtypes of AIS
In this study, we evaluated the influences of HRPR after ADP stimuli on the 1-year incidence of recurrent cardiovascular events and mortality in AIS with APAs. We conducted an observational, referral center cohort study on 968 AIS patients with APAs from January 2010 to December 2013 who were evaluated using optical platelet aggregometry (OPA). All patients received the dual APA combination of aspirin and clopidogrel or aspirin alone. We evaluated their platelet function 5 days after hospital admission using OPA. HRPR after ADP stimuli was defined as platelet aggregation of 70 % or greater according to OPA after 10 µM ...
Source: Journal of Thrombosis and Thrombolysis - December 17, 2015 Category: Hematology Source Type: research

Clinical and laboratory predictors of deep vein thrombosis after acute stroke
Deep vein thrombosis (DVT) is a common complication of acute stroke, but the new incidence in the era of improved specialist input in stroke care is yet unknown. The models for VTE diagnosis is well established, but prediction models to target at-risk patients for pharmacological prophylaxis is lacking and requires further research, particularly in the aftermath of acute stroke.
Source: Thrombosis Research - April 8, 2016 Category: Hematology Authors: Ibrahim O. Balogun, Lara N. Roberts, Raj Patel, Rohan Pathansali, Lalit Kalra, Roopen Arya Tags: Full Length Article Source Type: research

Safety and efficacy of non-vitamin K oral anticoagulant treatment compared with warfarin in patients with non-valvular atrial fibrillation who develop acute ischemic stroke or transient ischemic attack: a multicenter prospective cohort study (daVinci study)
Abstract The safety and efficacy of non-vitamin K oral anticoagulant (NOAC) compared with warfarin in treating patients with non-valvular atrial fibrillation (NVAF) who developed acute ischemic stroke or transient ischemic attack (AIS/TIA), particularly those receiving tissue-plasminogen activator (tPA) therapy, remains unclear. Between April 2012 and December 2014, we conducted a multicenter prospective cohort study to assess the current clinical practice for treating such patients. We divided the patients into two groups according to the administration of oral anticoagulants (warfarin or NOACs) and tPA therapy. ...
Source: Journal of Thrombosis and Thrombolysis - May 19, 2016 Category: Hematology Source Type: research

Clinical and laboratory predictors of deep vein thrombosis after acute stroke; does D-dimer really improve predictive power?
We have read with great interest the paper “Clinical and laboratory predictors of deep vein thrombosis after acute stroke” by Balogun et al. [1], in which the authors investigate the interesting and relevant topic of deep vein thrombosis (DVT) prediction after acute stroke. Specifically, their main research question focusses on the predictive value of stroke severity score and markers of haemostatic activation. This is a relevant question as venous thrombosis, mainly manifested as DVT and pulmonary embolism, is regarded as a serious, potentially life-threatening complication in stroke patients, even though the reports ...
Source: Thrombosis Research - July 3, 2016 Category: Hematology Authors: Vasilis Kola, Hugoline de Haan, Bob Siegerink Tags: Correspondence Source Type: research

Thrombolysis and Thrombectomy for Acute Ischemic Stroke: Strengths and Synergies
Semin Thromb HemostDOI: 10.1055/s-0036-1585078Acute ischemic stroke is responsible for around 80% of all strokes and is a leading cause of disability and death globally. There are two potential treatment strategies: restoring blood flow (reperfusion) and preventing cellular injury (neuroprotection). As yet, all the successful trials have involved reperfusion with numerous failures of neuroprotectants. There are two proven reperfusion strategies. Intravenous thrombolysis with alteplase was first demonstrated to reduce disability with publication of the National Institute of Neurological Disorders and Stroke tissue plasminog...
Source: Seminars in Thrombosis and Hemostasis - July 28, 2016 Category: Hematology Authors: Campbell, Bruce C. V. Tags: Review Article Source Type: research

Hemostasis Biomarkers and Risk of Sepsis: the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
CONCLUSION: Baseline fibrinogen, factor IX, and factor XI are associated with future episodes of sepsis. Hemostasis biomarkers may provide targets for sepsis mitigation or prevention. This article is protected by copyright. All rights reserved. PMID: 27512924 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 10, 2016 Category: Hematology Authors: Moore JX, Zakai NA, Mahalingam M, Griffin RL, Irvin MR, Safford MM, Baddley JW, Wang HE Tags: J Thromb Haemost Source Type: research

Optimising stroke prevention in elderly patients with atrial fibrillation
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 24, 2016 Category: Hematology Authors: Gregory Y H Lip Tags: Commentary Source Type: research

Early introduction of direct oral anticoagulants in cardioembolic stroke patients with non-valvular atrial fibrillation
AbstractDirect oral anticoagulants (DOACs) are superior to warfarin in reduction of the intracranial bleeding risk. The aim of the present study was to assess whether early DOAC introduction (1 –3 days after onset) in stroke patients with non-valvular atrial fibrillation (nVAF) may be safe and effective, compared with DOAC introduction after 4–7 days. We conducted a prospective analysis based on data collected from 147 consecutive nVAF patients who started DOAC within 7 days after stro ke onset. In all patients, we performed pre-DOAC CT scan 24–36 h after onset and follow-up CT scan at 7 days after DOAC introduction...
Source: Journal of Thrombosis and Thrombolysis - September 3, 2016 Category: Hematology Source Type: research

Fibrin clot characteristics in acute ischaemic stroke patients treated with thrombolysis: the impact on clinical outcome.
In conclusion, formation of denser fibrin clots displaying impaired lysability and pattern of their changes induced by thrombolysis may affect clinical outcome in AIS patients. PMID: 28382369 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - April 6, 2017 Category: Hematology Authors: Bembenek JP, Niewada M, Siudut J, Plens K, Członkowska A, Undas A Tags: Thromb Haemost Source Type: research